Download Table S13. Description of TCOF1 related proteins

Table S13. Description of TCOF1 related proteins analysed by STRING database
Gene
Name
Reference
Number
Description
9606.ENSP0000
HBG2
hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains
0338082
POLR1
9606.ENSP0000
polymerase (RNA) I polypeptide C, 30kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common
C
0361465
component of RNA polymerases I and III which synthesize ribosomal RNA precu
9606.ENSP0000
chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex
0301019
necessary to initiate DNA replication. Binds DNA in a sequence-,
CDT1
9606.ENSP0000
NOP56
microRNA 1292; Required for 60S ribosomal subunit biogenesis
0370589
9606.ENSP0000
ANXA6
annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores
0346550
9606.ENSP0000
replication factor C (activator 1) 1, 145kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This
0261424
subunit binds to the primer-template junction. Binds the PO-B
9606.ENSP0000
flap structure-specific endonuclease 1; Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a
0305480
downstream Okazaki fragment. Also possesses 5' to 3' exonuclease
CDKN1
9606.ENSP0000
cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and
A
0244741
inhibits cyclin-dependent kinase activity, preventing phos
9606.ENSP0000
replication factor C (activator 1) 3, 38kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear
0369411
antigen (PCNA) and activator 1
9606.ENSP0000
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the
0261797
glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharid
9606.ENSP0000
replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear
0296273
antigen (PCNA) and activator 1. This subunit may be involved i
RFC1
FEN1
RFC3
NDST1
RFC4
9606.ENSP0000
CDK4
cyclin-dependent kinase 4; Probably involved in the control of the cell cycle
0257904
9606.ENSP0000
MKLN1
muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin 1 (By similarity)
0323527
9606.ENSP0000
upstream binding transcription factor, RNA polymerase I; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions
0302640
with the transcription factor SL1/TIF-IB complex. It binds specif
9606.ENSP0000
replication factor C (activator 1) 2, 40kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear
0055077
antigen (PCNA) and activator 1. This subunit binds ATP (By sim
UBTF
RFC2
9606.ENSP0000
CCND1
cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition
0227507
GADD4
9606.ENSP0000
5G
0252506
growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK
9606.ENSP0000
mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby
0234420
initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields
9606.ENSP0000
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's
0368438
processibility during elongation of the leading strand (By similar
MSH6
PCNA
9606.ENSP0000
LIG1
ligase I, DNA, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair
0263274
9606.ENSP0000
transducin (beta)-like 1X-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in
0217964
transcription activation mediated by nuclear receptors.
9606.ENSP0000
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6
0233146
heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA
9606.ENSP0000
polymerase (DNA directed), delta 1, catalytic subunit 125kDa; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in
0262266
the 3'- to 5'-direction. Required with its accessory proteins
GADD4
9606.ENSP0000
growth arrest and DNA-damage-inducible, alpha; Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA
5A
0360025
excision repair in vitro and inhibits entry of cells into S ph
9606.ENSP0000
DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation
0352516
pattern in the newly synthesized strand, that is essential for epige
TBL1X
MSH2
POLD1
DNMT1
9606.ENSP0000
Treacher Collins-Franceschetti syndrome 1; May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the
0406888
craniofacial complex (By similarity)
TCOF1
9606.ENSP0000
POLD3
polymerase (DNA-directed), delta 3, accessory subunit; Required for optimal DNA polymerase delta activity
0263681
DYNC1
9606.ENSP0000
dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the
H1
0348965
force-producing power stroke is thought to occur on release o
9606.ENSP0000
POLD2
polymerase (DNA directed), delta 2, regulatory subunit 50kDa; The function of the small subunit is not yet clear
0379148
POLR1
9606.ENSP0000
polymerase (RNA) I polypeptide D, 16kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core
D
0302478
component of RNA polymerases I and III which synthesize ribosomal RNA
9606.ENSP0000
replication factor C (activator 1) 5, 36.5kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear
0408295
antigen (PCNA) and activator 1
RFC5