Download Research Scientist, Molecular and Cell Biology

Research Scientist, Molecular and Cell Biology
Crescendo Biologics (www.crescendobiologics.com) is a leading Cambridge-based
biotechnology company developing next generation Humabody® VH therapeutics derived
from the company’s unique transgenic platform. Crescendo is building an exciting portfolio
of novel oncology products in areas of high unmet need, including both Humabody Drug
Conjugates (HDCs) and novel multispecific Immuno-Oncology modulators that leverage the
advantages of the Humabody format.
The company is now looking for a talented, creative and motivated molecular and cell
biologist to join the team. The successful candidate will join active drug discovery
programmes and can expect to be involved with a broad range of different activities but
particularly:
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Building phage libraries derived from our transgenic mouse platform
Phage display; isolation of lead Humabody VH; lead optimisation
Vector design and construction, transfection of mammalian cells, protein production
Generation of clonal cell lines with constitutive or inducible transgene expression
Engineering of custom cell lines
Candidates will also be expected to be proactive in contributing previous experience to
reviewing and driving process optimisation.
Although training will be given in all aspects of the role, applications are particularly
encouraged from scientists with the following skills:
Essential:
 Molecular biology: e.g. RNA extraction, cDNA preparation, PCR, cloning, mutagenesis,
genomic DNA extraction, genotyping, protein purification, Western blot
 Cell culture, using a range of cell types
 Excellent sterile technique
 An interest in cell engineering and new technologies
Desirable:
 Phage display, selection and screening
 Antibody sequence analysis
 Flow cytometry
 Genetic manipulation of cells in vitro
 Use of genome databases
Person Specification
 PhD qualification or equivalent
 Excellent laboratory skills
 Highly organised with good attention to detail
 Flexible and pro-active with a willingness to tackle both new and routine tasks
 Good communicator
 Good team worker
In addition, candidates will also be expected to:
 Co-ordinate and co-operate with other personnel over the day to day running of the
laboratory.
 Have excellent abilities in record keeping and maintenance of clearly written laboratory
notebooks to a standard required for publications and patent filings
 Contribute to company Health & Safety policies and implementation
Crescendo Biologics offers a competitive compensation package including private medical
insurance, life assurance, pension scheme and membership of the company share option
plan. Our premises are located on the Babraham Research Campus to the south of
Cambridge, and staff members have access to Campus facilities including an on-site nursery,
canteen, gym and sports and social club.
Candidates should be legally entitled to work in the UK.