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for subpathways leading to stimulation of the cell cycle, which may be affected by the “Adherens
junction” pathway, and to Cytoskeletal changes, which may be affected by the “Focal adhesion”
pathway. Following Salmonella infection line A shows up regulation of both processes. No such effect
was observed in line B. After24 h infection with Salmonella the subpathways are still higher expressed
in line B compared to line A. Thus, the up regulation associated with Salmonella infection not sufficient
to level the line differences.
B-cell receptor signalling: The B-cell receptor pathway may be involved in the reaction of the chicken
to Salmonella infection, and one subpathway of this pathway leads to input for the “Regulation of
cytoskeleton” pathway. Chicken line differences resulted in a higher expression in line A compared to
line B of this latter subpathway. Following Salmonella infection line A shows down regulation and line
B shows up regulation of this subpathway. This subpathway shows equal expression between the lines
after 24 h infection with Salmonella. It can be concluded that this equal expression levels is the result
of the differential regulation of the lines.
T cell receptor signalling: Chicken line differences seem not to affect expression of this pathway.
Following Salmonella infection both lines show up regulation of several genes in this pathway, where
especially in line A more up regulated genes were found than in line B. Only in line A up regulation of
the input signal for the “Regulation of actin cytoskeleton” pathway is visible. This subpathway shows
equal expression between the lines after 24 h infection with Salmonella.
The Regulation of actin cytoskeleton pathway is in the centre of all these regulatory mechanisms. The
pathway describes the regulation of several different steps in changes in the actin cytoskeleton and
interactions with other pathways. Chicken line differences resulted in a higher expression in line B
compared to line A of the subpathways leading to the formation of stress fibres and two different
subpathways leading to input in the “Focal adhesion” pathway. Following Salmonella infection line A
shows up regulation of one subpathway leading to input in the Focal adhesion pathway (but not the
other) and uncertain regulation of stress fibre formation. Line B shows limited regulation. This
subpathway shows equal expression between the lines after 24 h infection with Salmonella.