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Discussion As we near the end of this term, let’s put everything together and discuss an important application of genetics: gene therapy. The overall goal of gene therapy is to restore normal function in cells that are affected by genetic disorders. How does gene therapy work? What are the challenges of gene therapy? Research the stories of Ashanti de Silva and Jesse Gelsinger. Based on the outcomes of these treatments, do you think experimental gene therapy trials should continue? Address all Discussion topics in the Discussion area. Your initial post should be at least 100 words and contain references. In addition, respond to at least two of your colleagues’ posts with meaningful comments in accordance with the Syllabus. Each post should be at least 50 words. Please be sure to cite all of your sources. Gene therapy can be good Edward Jackson 8/31/2013 1:28:10 PM How does gene therapy work? Cells are not perfect…and they do break down from time to time; this could lead to mutations in a person’s genes at the cellular level. What gene therapy does is insert a modified gene into the individual’s cell in hopes to replace a “bad” allele with a “good” one. There actually has been pretty good success up to now with this type of treatment. What are the challenges of gene therapy? The main problems are: the science is quite new, so we are still learning; and two, is delivering the correct modifications to large sections of DNA. If you don’t deliver the modified alleles to the proper locations, the treatment won’t work; or worse, could potentially have fatal ramifications. Good examples of these larger DNA patches not working are when scientist tried to treat cystic fibrosis, hemophilia, and muscular dystrophy (News Medical). Ashanti de Silva and Jesse Gelsinger In the research studies of Ashanti de Silva and Jesse Gelsinger, some things were done correctly, and some things were not. I am all for the continued treatment and usage of gene therapy, however, there must always be a full disclosure of the risks, and the outcomes of the research. I believe gene therapy will probably find a cure or a much better treatment for cancer, as that is where most of the focus of research is now. News Medical. (n.d.). What is Gene Therapy? Retrieved from http://www.news-medical.net/health/What-is-Gene-Therapy.aspx ----------------------------------------------------------Eddie Jackson GOK - Philosophy Major/Liberal Studies http://eddiejackson.net/ RE: Main Post_M.VITAL university page 9/1/2013 12:23:58 PM Edward Jackson I am for gene therapy…but only if there is transparency in the possible risks, testing, and outcomes of the treatment. I also would like to see more readily available public knowledge and shows, such as news coverage on this amazing science. One particular aspect that I don’t like is that there is a possible war use of the technology; biological warfare. Can you imagine the wars of the future where terrorists put something into our drinking water…or even air for that matter…that could alter our genes? ----------------------------------------------------------Eddie Jackson GOK - Philosophy Major/Liberal Studies http://eddiejackson.net/ university page You’re right, there are some major issues with the gene therapy treatment…but I believe the good outweighs the bad. Let me tell you why. Most people who are seeking gene therapy are not well in the first place; many are terminal. There is also the future of science to consider. We need to continue to be progressive with our science so that all humans of the future may benefit from medical and genetic advancements. I only have 2 concerns really; one is transparency; the other is war usage…both of which need to be closely watched.