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Biology 30 Module 3 Assignment 13 Copyright: Ministry of Education, Saskatchewan May be reproduced for educational purposes Biology 30 235 Assignment 13 Biology 30 236 Assignment 13 Biology 30 237 Assignment 13 Biology 30 238 Assignment 13 Assignment 13 Values (20) A. Multiple Choice: Select the best answer for each of the following and place a check () beside it. 1. 2. In humans, the sex of an offspring is actually determined by ***. ____ ____ ____ a. b. c. ____ d. A woman whose father had hemophilia and whose mother was normal, married a man whose father was normal and whose mother had hemophilia. If their first child was a son, there would be a *** chance that he would show the trait of hemophilia. ____ ____ ____ ____ 3. 0%. 25%. 50%. 100%. a. b. c. d. Colorblindness. Hemophilia. Baldness. Down's Syndrome. Dr. Karl Landsteiner is primarily associated with ***. ____ ____ ____ ____ Biology 30 a. b. c. d. The human condition *** develops as a result of nondisjunction. ____ ____ ____ ____ 4. the female's sex chromosomes the male's sex chromosomes either the female or the male, depending upon which is stronger or more healthy at the time of conception the body chromosomes of both the female and male a. b. c. d. the one gene-one protein concept blood types sex-linkage chromosome maps 239 Assignment 13 5. If there is a high frequency of cross-over between two genes, it is likely that these genes ***. ____ ____ ____ ____ 6. a. b. c. d. show possible abnormalities in chromosomes illustrate the lengths and shapes of chromosomes establish chromosomes as homologous pairs establish the locations of genes on chromosomes a. b. c. d. 2 3 4 6 A blood type which is always an indication of a heterozygous condition is type ***. ____ ____ ____ ____ Biology 30 useful to humans useful to organisms either harmful or of no use to the organisms neither useful nor harmful to organisms There are three alleles present for a certain trait. Two of these are codominant with each other and the third allele is recessive to both codominants. The total number of phenotypes possible for the trait is ***. ____ ____ ____ ____ 9. a. b. c. d. The main purpose of gene maps is to ***. ____ ____ ____ ____ 8. are far apart on the same chromosome are close together on the same chromosome experience more mutations in either one or the other occupy similar positions on different chromosomes Most mutations are ***. ____ ____ ____ ____ 7. a. b. c. d. a. b. c. d. A B AB O 240 Assignment 13 10. *** percent of sons from a carrier female and a colorblind male can be expected to be colorblind. ____ ____ ____ ____ 11. a. b. c. d. 0%. 25%. 50%. 100%. Mutant genes very often do not express themselves for many generations. This is because ***. ____ ____ a. b. ____ ____ c. d. gene mutations happen very infrequently most gene mutations are lethal and kill the offspring before birth many gene mutations are recessive gene changes will not appear until environmental conditions are just right 12. The preceding graphic shows a human pedigree involving blood type. One daughter has a known blood type of AB and one son has a known blood type of O. The genotypes of the parents are likely ***. ____ ____ ____ ____ Biology 30 a. b. c. d. IAi, IAIB ii, IAIB I AI A, I BI B IAi, IBi 241 Assignment 13 13. 14. The main characteristic of the fruitfly, Drosophila, which makes it suitable for genetic studies is that ***. ____ a. ____ ____ ____ b. c. d. A male mammal carrying a sex-linked gene on the X chromosome would transmit this gene to ***. ____ ____ ____ ____ 15. 17. one-half of his female offspring one-half of his male offspring all of his female offspring all of his male offspring a. b. c. d. roan cattle tall and short garden peas human ABO blood types human skin color An actual gene is considered to be ***. ____ a. ____ b. ____ ____ c. d. three nitrogen bases in a DNA molecule which code a specific amino acid a series of codons which direct the formation of one complete protein messenger RNA, which carries out the "orders" of DNA all the DNA bases in one "twist" of the DNA helix Genes responsible for alternate expressions of one particular trait are known as ***. ____ ____ ____ ____ Biology 30 a. b. c. d. An example of polygenic inheritance is that of ***. ____ ____ ____ ____ 16. it does not usually experience mutations to confuse results it is quite small it has a very short life cycle the different sexes are similar in size a. b. c. d. genotypes phenotypes polygenes alleles 242 Assignment 13 18. People who have red hair generally have freckles as well. This can best be explained by ***. ____ ____ ____ ____ 19. a. b. c. d. fertile female female not likely to survive into adulthood sterile female sterile male with feminine traits If a "strange" nucleotide is inserted into a certain spot in a DNA chain, it results in a(n) ***. ____ ____ ____ ____ Biology 30 linkage independent assortment codominance polyploidy A human with the sex chromosome combination XXX would probably be a ***. ____ ____ ____ ____ 20. a. b. c. d. a. b. c. d. inversion chromosomal mutation multiple allele formation frameshift mutation 243 Assignment 13 (8) B. Matching: In the space provided in front of each item in Column A, write the letter of the correct answer from Column B. Column A ____ C. (3) 1. Column B shows the location of genes on a chromosome ____ 2. universal donor ____ 3. Beadle and Tatum ____ 4. changes to one or two bases in a sequence ____ 5. name given to chromosomes other than sex chromosomes ____ 6. universal recipient ____ 7. used to clone DNA fragments to hi-lite genetic markers in a genome ____ 8. phenotypes affected by the cumulative effect of two to five different pairs of genes a. autosomes b. gene map c. polymerase chain reaction d. polygene e. one gene produces one protein f. type O blood g. point mutation h. type AB blood Short Answer 1. Identify the type of chromosomal mutation in each of the following: a. ____________________ b. ____________________ c. ____________________ Biology 30 244 Assignment 13 (10) Biology 30 2. Indicate the purpose of each of the following: a. A chorionic villi biopsy. b. A Punnett Square. c. A pedigree. d. A karyotype. e. A plant breeder administering colchicine to certain plant cells. 245 Assignment 13 (12) 3. a. b. c. Biology 30 i. Briefly indicate two ways in which gene mutations can occur. ii. Briefly indicate two ways in which chromosomal mutations can occur. i. What are mutagens? (The general meaning.) ii. List four possible mutagens. In what way could mutations be valuable from the viewpoint of an entire species? 246 Assignment 13 (8) Biology 30 4. Blood typing is sometimes used to determine the identities of possible parents of certain children. In each of the following two examples, both the mother's and the child's blood types are known. The blood types of two possible fathers are given in each situation. Identify the likely father of the child in each case. State the reasoning for your decision. (Show your work) a. The mother belongs to type B, the child to O. One possible father is type A and the other is type AB. b. The mother belongs to type B, the child to AB. One possible father is type A and the other is B. c. A person of blood group AB marries one belonging to group O. Use a Punnett Square to show the probable blood types of their children. 247 Assignment 13 (9) 5. a. In the section on sex-linkage in this lesson, a pedigree or chart tracing colorblindness in several family generations was presented. Using XC to represent a chromosome carrying a gene for normal vision and Xc to represent a chromosome with a gene for colorblindness, identify the numbered individuals in the chart. Beside each number, identify the most probable genotype of the individual having the same number in the preceding chart. (Be sure the sizes of the c's give an indication of whether they are capital or lowercase.) Individual 1 ____________________ Individual 2 ____________________ Individual 3 ____________________ Individual 4 ____________________ Individual 5 ____________________ Biology 30 248 Assignment 13 b. (9) 6. In the following human pedigree, the hachured (or partially shaded) individuals are those displaying a particular trait. Nonhachured or clear individuals do not show the trait. a. Biology 30 In the preceding example, if individual 3 had the same genotype as individual 1, what differences (if any) could you have seen in individual 3's two sons? Give a reason for your answer. State the reasoning that you would use to explain why the particular trait is not sex-linked. (If you wish, you may use the numbers of individuals to assist in your explanation.) 249 Assignment 13 Biology 30 b. What manner of inheritance does the trait follow and briefly give the reason. c. Suppose individual #6 was carrying and showing a sexlinked trait. Set up a pedigree chart with individuals 6 to 10, showing what changes (if any) should occur with 8, 9 and 10. If there are changes, or no changes, indicate the reasons. 250 Assignment 13 (6) (4) 8. 7. Explain the significance of the Rh protein factor in human blood. a. What inheritance pattern is indicated in the pedigree below for colorblindness? (Inheritance pattern could refer to such combinations as: dominant-recessive, codominance, incomplete dominance, sex-linkage …) Inheritance pattern: b. _________________________________________ Explain your reasoning for choosing that pattern. Use this pedigree to answers questions 8 and 9. Biology 30 251 Assignment 13 Refer to the pedigree in question 8 to answer the following question. (11) 9. a. Establish the letters that you wish to use to express normal vision and colorblindness. (Show the traits on the X chromosome.) Normal vision: ____________________ Colorblindness: ____________________ b. Using the letters you have chosen in (a), indicate the probable genotypes of the following individuals: I-1 _________________ I-2 _________________ II-1 _________________ II-2 _________________ II-3 _________________ II-5 _________________ II-6 _________________ III-2 _________________ III-5 _________________ _____ (100) Biology 30 252 Assignment 13