Download Annexure `AAB-CD-01` L T P/S SW/FW TOTAL CREDIT UNITS 2 0 0

Annexure ‘AAB-CD-01’
Course Title: Developmental Biology & Stem Cell Physiology
Course Code:
Credit Units: 3
Level: PG (M.Sc)
L
T
P/S
SW/FW
TOTAL
CREDIT
UNITS
2
0
0
0
2
Course Objectives:
Acquire fundamental knowledge of animal embryonic development and how genes function to control phenotype of an organism.
Apply concepts of stem cell biology in the setting of the developmental process.
Prerequisites: Knowledge of cell biology
Course Contents / Syllabus:
Module I: Principles of Developmental Biology
20% Weightage
Introduction to developmental biology, model systems for studying developmental biology, stages of animal
development, Genomic equivalence, maternal and zygotic factors, dosage compensation, Drosophila segmentation,
polarization and axis determination
Module II: Development in Vertebrates
40% Weightage
Gametogenesis, fertilization, Cleavage, blastocyst formation, implantation, cell movement (Invagination,
Involution, Ingression, Delamination, Epiboly), Gastrulation, Morphogenesis and Cell Adhesion and Axis
determination in various model systems such as birds, frog, mammals, morphogenesis
CNS - neural tube development, neuronal cell types, specification, somite formation, tissue patterning, heart
development
MODULE III: Signaling in Development & Stem Cell Physiology
25% Weightage
Cell communication and differential gene expression in development with emphasis on Hedgehog, Wnt, Notch and
TGF-β signaling, morphogen gradients, Signaling in cell fate decisions
Module IV: ES Cell as a Model System for Developmental Studies
Lineage commitment during development, & differentiation, Environmental Regulation of Normal Development,
Abnormal Development and Teratology
Student Learning Outcomes: At the end of the course, students would be able to
 Illustrate fundamental concepts of developmental biology
 Propose the significance of cell communication with reference to development
 Evaluate the mechanism of lineage commitment and organogenesis with special reference to stem cells
Pedagogy for Course Delivery:
Lectures: 41 sessions
Presentation / Seminar: 1 session
Class Test: 2 sessions
Revision: 1 session
Total: 45 sessions
Assessment/ Examination Scheme:
Theory L/T (%)
Lab/Practical/Studio (%)
100%
--
100%
Theory Assessment (L&T):
Continuous Assessment/Internal Assessment
Components Class
Test 1
(Drop
down)
Weightage
(%)
10
End Term Examination
Class
Test 2
Home
Assignment
End
Attendance
Total
Term
Examination
10
5
5
70
100
20% Weightage
Text / Reference Books:



Molecular biology of the Cell by Bruce, Alberts and Alexander Johnson and Julian Lewis, and Martin Raff; Ed. 5th; Garland
Science; 2008.
Developmental Biology. Scott F Gilbert 10th Edition;2013
Companion to Developmental Biology by Gilbert .http://10e.devbio.com/
Other Study Material:

Research Papers and Review Articles Published in Peer-Reviewed Scientific Journals.