Download Pharmaceutical Faculty 3- d course Module 1 General principles of

Pharmaceutical Faculty
3- d course
Module 1
General principles of metabolism. Metabolism of carbohydrates, lipids and its
regulation
1. Glycogenolysis refers to
A.
The formation of glycogen
B.
The formation of urea
C.
Conversion of fat and/ or protein to glucose
D.
The anaerobic metabolism of glucose
E.
Conversion of glycogen to glucose
ANSWER: E
2. The regulation of normal blood sugar level is accomplished by
A.
Insulin, glucagon and adrenalin
B.
Cell tissue absorption of glucose from the blood
C.
The breakdown of glycogen by the liver
D.
Glycogenesis and glycogenolysis
E.
All of the above
ANSWER: E
3. Anaerobic metabolism refers to the generation of ATP:
A.
Without the involvement of ADP
B.
Without the use of glycogen
C.
In the absence of available oxygen
D.
By the conversion of pyruvate to lactate
E.
Without the use of oxygen
ANSWER: E
4. Phospholipase A2 is an enzyme which removes a fatty acid residue from
lecithin to form
A.
Lecithin fragments
B.
Phosphotidic acid
C.
Glyceryl phosphate
D.
Both A and D
E.
Lysolecithin
ANSWER: E
5. Pancreatic lipase is an enzyme which hydrolyzes fats. It acts as a/an
A.
Peptidase
B.
Carbohydrates
C.
Dehydrogenase
D.
None of the above
E.
Hydrolase
ANSWER: E
6. Bile is produced by
A.
Gall-bladder
B.
Pancreas
C.
Intestine
D.
All of the above
E.
Liver
ANSWER: E
A.
B.
C.
D.
7. In beta-oxidation of fatty acids which of the following are utilized as
co-enzymes?
NAD+ and NADP+
FAD H2 and NADH + H+
FAD and FMN
All of these
E.
FAD and NAD+
ANSWER: E
8. What is the major role of phospholipase A2?
A.
To cleave the phosphate group from phospholipids
B.
To phosphorylate the enzyme enoyl-CoA
C.
To transport glycerophospholipids in the blood
D.
None of the above
E.
To hydrolyze an ester bond in glycerophospholipids to form
lysophosphoglyceride
ANSWER: E
9. Which dietary lipid usually contains no ester bonds?
A.
Triacylglycerides
B.
Glycerophospholipids
C.
None of the above, all dietary lipids are esterified.
D.
All of the above
E.
Cholesterol
ANSWER: E
10.
Which lipid form is transported across the inner mitochondrial
membrane before beta-oxidation?
A.
Fatty acyl CoA
B.
Acetoacetyl CoA
C.
Lysophospholipid CoA
D.
All of the above
E.
Acylcarnitine
ANSWER: E
11.
How many cycles of beta-oxidation are required to completely process
a saturated C18 fatty acid?
A.
6
B.
9
C.
18
D.
7
E.
8
ANSWER: E
12.
Lipids may be either hydrophobic or
A.
Hydrophilic
B.
Organic
C.
Inorganic
D.
Soluble in polar solvents
E.
Amphipathic
ANSWER: E
13.
Fatty acids required in the diet of mammals are called
A.
Important
B.
Dietary
C.
Saturated
D.
Esters
E.
Essential
ANSWER: E
14.
Dietary triacylglycerols are digested as a result of
A.
Lipase action
B.
Bile salts
C.
Micelle formation
D.
Diffusion and absorption by intestinal cells
E.
All of the above
ANSWER: E
A.
15.
The main function of the bile salts is to __________.
Act as counterions for the ionized forms of lipids
B.
Cleave the ester bonds in triacylglycerols to release free fatty acids
C.
Form the surface layer of chylomicrons
D.
None of the above
E.
Emulsify lipids in the intestin
ANSWER: E
16.
The largest lipoproteins are the __________.
A.
VLDLs
B.
LDLs
C.
HDLs
D.
None of the above
E.
Chylomicrons
ANSWER: E
17.
The main sources of NADPH for fatty acid biosynthesis is:
A.
TCA cycle
B.
Oxidative phosphorylation
C.
Glycolysis
D.
All of the above
E.
The pentose phosphate pathway
ANSWER: E
18.
For the patient with diagnosis atherosclerosis “Linetol” is
prescribed, which contains essential fatty acids. Which of the belowmentioned acids surely is a part of it?
A.
Stearic acid
B.
Palmitic acid
C.
Oleic acid
D.
Crotonic acid
E.
Linoleic acid
ANSWER: E
19.
The amount of phospholipids in the blood plasma of 45 years old
patient is normal. Choose correct result:
A.
2,0-5,0 g/l
B.
1,2-2,5 g/l
C.
0,7-2,0 g/l
D.
7,0-8,0 g/l
E.
1,5-3,6 g/l
ANSWER: E
20.
After having fatty food the patient had nausea and steatorrhea. The
cause of this condition can be:
A.
Amylase insufficiency
B.
Increase of lipase excretion
C.
Trypsin synthesis malfunction
D.
Increased acidity of gastric juice
E.
Lack of bile acids
ANSWER: E
21.
Patient suffers from disorders of lipid digestion. What are the
functions of bile salts in lipid digestion?
A.
Emulsification of lipids; decompose the cholesteryl esters
B.
Activation of phospholipase A2; activation of cholesterol esterase
C.
Inhibition of lipase; inhibition of phospholipase A2
D.
All of the above
E.
Emulsification of lipids; activation of lipase
ANSWER: E
22.
Why snake venom causes the lysis of erythrocytes?
A.
Contains hemolytic toxins which directly destroy the erythrocytes membranes
B.
Contains lipase catalyzing the hydrolysis of triacylglycerols in the
cellular membranes
C.
Contains cholesteryl esterase catalyzing the hydrolysis of cholesterol
esters in the cellular membranes
D.
None of the above
E.
Contains phospholipase A2 catalyzing the hydrolysis of glycerophospholipids
and formation of lysophosphoglycerides which can act as detergents and disrupt
cellular membranes
ANSWER: E
23.
Conncentration of LDL in blood of the patient is increased. Low
density lipoproteins transport ________________ from __________ to
___________
A.
Triacylglycerols; intestine; liver
B.
Cholesterol; peripheral tissues; liver
C.
Triacylglycerols; liver; adipose tissue and muscles
D.
Triacylglycerols; liver; muscles
E.
Cholesterol; liver; peripheral tissues
ANSWER: E
24.
In an organism of 47 years old patient mobilisation of lipids is
active. Tryacylglycerinlipase of fatty tissue is activated by:
A.
Adenosine triphosphate
B.
Guanosine triphosphate
C.
Adenosine diphosphate
D.
Guanosine diphosphate
E.
Cyclic adenosine monophosphate
ANSWER: E
25.
Old-time physicians often diagnosed illness on the basis of the odor
of patients. Untreated diabetics sometimes have breath with a "fruity"
odor due to the presence of a volatile ketone body. Which one?
A.
Beta-hydroxybutyric acid
B.
Pyruvic acid
C.
Stearic acid
D.
Acetoacetic acid
E.
Acetone
ANSWER: E
26.
Drugs called statins are now used to decrease plasma cholesterol
levels by inhibiting the rate-limiting step of cholesterol synthesis. This
step is catalyzed by
A.
Lipoprotein lipase
B.
Beta-ketothiolase
C.
Acyl carrier protein
D.
Transacylase
E.
HMG-CoA reductase
ANSWER: E
27.
HDL is synthesized and secreted from
A.
Pancreas
B.
Kidney
C.
Muscle
D.
Lung
E.
Liver
ANSWER: E
28.
All of the following tissue are capable of using ketone bodies
except
A.
Brain
B.
Renal cortex
C.
Cardiac muscle
D.
Skeletal muscle
E.
Liver
ANSWER: E
29.
Ketone bodies are synthesized from fatty acid oxidation products by
which of the following organs?
A.
Skeletal muscles
B.
Kidney
C.
Brain
D.
Heard
E.
Liver
ANSWER: E
Which of the following metabolite integrates glucose and fatty acid metabolism?
A.
Pyruvate
B.
Citrate
C.
Lactate
D.
Fumarate
E.
Acetyl CoA
ANSWER: E
30.
An aneplerotic reaction which sustains the availability of
oxaloacetate is the carboxylation of
A.
Glutamate
B.
Citrate
C.
Succinate
D.
Lactate
E.
Pyruvate
ANSWER: E
31.
Pyruvate dehydrogenase complex and alfa-ketoglutarate dehydrogenase
complex require the following for their oxidative decarboxylation:
A.
CoASH and Lipoic acid
B.
NAD+ and FAD
C.
CoASH and TPP
D.
CoASH, TPP, FAD, Lipoate
E.
CoASH, TPP,NAD+,FAD, Lipoate
ANSWER: E
32.
Oxidative decarboxylation of pyruvate requires
A.
NADP+
B.
Cytochromes
C.
Pyridoxal phosphate
D.
Pyridoxine
E.
CoASH
ANSWER: E
33.
A.
1
B.
3
C.
4
D.
5
E.
2
ANSWER: E
The number of ATP produced in the succinate dehydrogenase step is
34.
The following coenzyme is needed for the oxidative decarboxylation
of ketoacids:
A.
NADP+
B.
Folate coenzyme
C.
Biotin coenzyme
D.
Both B and C
E.
TPP
ANSWER: E
A.
B.
C.
35.
The conversion of pyruvate to acetyl CoA and CO2
Is reversible
Depends on the coenzyme biotin
Occurs in the cytosol
D.
Both A and B
E.
Involves the participation of lipoic acid
ANSWER: E
36.
Prosthetic group of cytochrome is:
A.
FAD
B.
Ubiqinon
C.
Biotin
D.
Cooper contain porphyryn complex
E.
Iron porphyryn complex
ANSWER: E
37.
How many ATP molecules can be derived from each molecule of acetyl
CoA that enters the Krebs’ Cycle?
A.
6
B.
18
C.
38
D.
39
E.
12
ANSWER: E
38.
Catabolism is a form of metabolism in which molecules are converted
into
A.
Large start product
B.
Peptides, proteins
C.
Food, storage
D.
All of the above
E.
Simple end product, energy
ANSWER: E
39.
Energy is carried from catabolic to anabolic reactions in the form
of
A.
ADP
B.
Coenzymes
C.
Inorganic phosphate
D.
Oxygen
E.
High-energy ATP bonds
ANSWER: E
40.
Which term most precisely describes the general process of breaking
down large molecules into smaller ones?
A.
Anabolism
B.
Dehydration
C.
Catalysis
D.
Metabolism
E.
Catabolism
ANSWER: E
41.
Anabolic pathways _______
A.
Do not depend on enzymes
B.
Lead to the synthesis of catabolic compounds
C.
Release energy as they degrade polymers to monomers
D.
All of the above
E.
Consume energy to build up polymers from monomers
ANSWER: E
42.
The coenzyme electron carriers produced in the Krebs cycle are
A.
ATP and ADP
B.
Pyruvate and acetyl CoA
C.
NAD and NADH
D.
NADH and ATP
E.
FADH2 and NADH
ANSWER: E
43.
Why is ATP an important molecule in metabolism?
A.
Its hydrolysis provides an input of free energy for exergonic reactions.
B.
Its terminal phosphate group contains a strong covalent bond that when
hydrolyzed releases free energy.
C.
A and B only
D.
A, B and C
E.
It provides energy coupling between exergonic and endergonic reactions.
ANSWER: E
44.
The patient with cyanide poisoning was delivered to clinic. What
mast be immediately used for the improvement of his state?
A.
Glucose
B.
Ascorbic acid
C.
Vitamin B1
D.
Nicotine amide
E.
Cytochromoxidase
ANSWER: E
45.
A deficiency in thiamin causes the disease beriberi. Which might you
expect to have a higher than normal blood concentration in an individual
with this condition?
A.
Isocitrate
B.
Oxaloacetate
C.
Acetyl CoA
D.
Malate
E.
Pyruvate
ANSWER: E
46.
In blood and urine of a patient an increase value of pyruvic and
ketoglutaric acids takes place. The deficiency of which coenzyme causes
these changes?
A.
Pyridoxal phosphate
B.
Flavin mononucleotide
C.
Biotin
D.
Ubiquinon
E.
Thiamin pyrophosphate
ANSWER: E
47.
As resalt of hypovitaminosis a 55 year old woman has sympthoms of
pyruvate oxidative decarboxilation inhibition. Aerobic oxidation of
pyruvate to CO2 and H2O results in formation of molecules ATP:
A.
38 ATP
B.
12 ATP
C.
3 ATP
D.
2 ATP
E.
15 ATP
ANSWER: E
48.
For treatment of many diseases cocarboxylase (thiaminpyrophosphate)
is used for providing of energy for cells. Choose what metabolic process
is activated in this case?
A.
Deamination of glutamate
B.
Decarboxylation of histidine
C.
Transamination of aspartate
D.
Substrate level phosphorylation
E.
Oxidative decarboxylation of pyruvate
ANSWER: E
49.
A.
B.
During wet beriberi (thiamin deficiency), peripheral vessels dilate
and heart muscles loose their contractility. Some people think this is a
result of a failure of the TCA cycle. Evidence for this is an increase in
the
Rate of production of succinate
Rate of production of NADH
C.
Production of ATP
D.
Production of FADH2
E.
Concentration of alpha-ketoglutarate and pyruvate
ANSWER: E
50.
A patient was diagnosed with beri-beri disease (thiamin deficiency).
Activity of which enzyme is inhibited in an organism of the patient?
A.
Fumarase
B.
Citrate synthase
C.
Malate dehydrogenase
D.
Succinate dehydrogenase
E.
Pyruvate dehydrogenase
ANSWER: E
51.
The accumulation of pyruvate in blood, decrease of activity of
transketolase of red blood cells takes place in organism of a 46 years old
chronic alcoholic. Insufficiency of coenzyme form of which vitamin causes
such changes?
A.
Carboxybiotin
B.
Metylcobalamin
C.
Phosphopyridoxal
D.
Tetrahydrofolate
E.
Thiamine diphosphate
ANSWER: E
52.
The coenzymes NAD and FAD carry electrons to the
A.
Nucleus
B.
Citric Acid cycle
C.
Plasma membrane
D.
Lysosoms
E.
Electron transport system
ANSWER: E
53.
When a phosphate is transferred from a high-energy molecule of ADP
to form ATP it's referred to as _____.
A.
Photophosphorylation
B.
Substrate-level phosphorylation
C.
Citric cycle
D.
Decarboxilation of pyruvat
E.
Oxidative phosphorylation
ANSWER: E
54.
The final electron acceptor in the electron transport system is
_____.
A.
FADH2
B.
Coenzyme Q
C.
Cytochrome b
D.
Cytochrome c
E.
O2
ANSWER: E
55.
How many ATP molecules are produced when FADH2 delivers electrons to
the electron transport system?
A.
1
B.
4
C.
36
D.
12
E.
2
ANSWER: E
56.
A.
B.
Almost all of the oxygen (O2) one consumes in breathing is converted
to:
Acetyl-CoA
Carbon dioxide (CO2)
C.
Carbon monoxide and then to carbon dioxide
D.
None of the above
E.
Water
ANSWER: E
57.
In the electron transport chain, the hydrogen ions enter the inner
compartment of mitochondria through special channels formed by
A.
Coenzyme A
B.
Acetyl CoA
C.
Oxygen
D.
Water
E.
ATP synthase
ANSWER: E
58.
The coenzyme electron carriers produced in the Krebs cycle are
A.
ATP and ADP
B.
Pyruvate and acetyl CoA
C.
NAD and NADH
D.
NADH and ATP
E.
FADH2 and NADH
ANSWER: E
59.
The iron-sulfur proteins appear to function as electron carriers by
undergoing reversible :
A.
Cu (I) to Cu (II) transitions
B.
Na (I) to Na (II) transitions
C.
Mg (I) to Mg (II) transitions
D.
None of the above
E.
Fe(II)-Fe(III) transitions
ANSWER: E
60.
The cytochromes are localized in the:
A.
Cytosol
B.
Nucleus
C.
Ribosoms
D.
Matrix of mitochondria
E.
Inner mitochondrial membrane
ANSWER: E
61.
FMN - prosthetic group of:
A.
Lactate dehydrogenase
B.
Alcohol dehydrogenase
C.
Creatin kinase
D.
Amino transferase
E.
NADH- dehydrogenase
ANSWER: E
62.
Antibiotic antimycin blocks electron transport in the span from:
A.
NADH to Fe-S proteins
B.
Cytochrome c to aa3
C.
NADH to ubiquinone
D.
NADH to cytochrome b
E.
Cytochrome b to c1
ANSWER: E
63.
A.
1
B.
10
C.
3
D.
5
E.
2
ANSWER: E
How many ways of ATP formation are in the organism?
64.
The main hormones that regulate the synthesis and decomposition of
glycogen are:
A.
Insulin, glucocorticoids, thyroxin
B.
Gglucagons, glucocorticoids, vasopressin
C.
Glucocorticoids, glucagons, epinephrine
D.
All of the above
E.
Insulin, glucagon, epinephrine
ANSWER: E
65.
Glycolysis is defined as:
A.
Aerobic process in which glucose is transformed to CO2 and H2O
B.
Anaerobic process in which glucose is transformed to pyruvate
C.
Anaerobic process in which glucose is converted to pentoses and NADPH is
produced
D.
Aerobic process in which glucose is converted to glycogen
E.
Anaerobic process in which glucose is transformed to lactate
ANSWER: E
66.
Glycolysis takes place in:
A.
Mitochondria
B.
Nucleus
C.
Lysosomes
D.
None of the above
E.
Cytoplasm
ANSWER: E
67.
The
are:
A.
Conversion
B.
Conversion
C.
Conversion
D.
All of the
E.
Conversion
ANSWER: E
68.
A.
1
B.
3
C.
4
D.
0
E.
2
ANSWER: E
69.
possible metabolic pathways for pyruvate in anaerobic conditions
to lactate
to ethanol
to lactate
above
to lactate
or acetyl CoA
or acetyl CoA
or ethanol or acetyl CoA
or ethanol
How many molecules of ATP have to be spent during glycolysis?
How many substrate level phosphorylation reactions are in
glycolysis?
A.
1
B.
3
C.
4
D.
0
E.
2
ANSWER: E
70.
The three control sites in glycolysis are the reactions catalyzed
by:
A.
Hexokinase, phosphofructokinase 1 and aldolase
B.
Phosphofructokinase 1, aldolase and pyruvate kinase
C.
Hexokinase, aldolase and pyruvate kinase
D.
All of the above
E.
Hexokinase, phosphofructokinase 1 and pyruvate kinase
ANSWER: E
71.
A.
A patient is found to be deficient in the enzyme galactose 1phosphate uridylyltransferase. Specifically due to this deficiency what
might a doctor recommend?
Avoid all strenuous exercise
B.
Eat a fat-free diet
C.
Increase intake of vitamin C
D.
All of the above.
E.
Avoid ingestion of milk and milk products
ANSWER: E
72.
The enzyme which the key regulatory step in glycogen biosynthesis is
A.
Glycogenin
B.
Branching enzyme
C.
Phosphoglucomutase
D.
UDP-glucose pyrophosphorylase
E.
Glycogen synthase
ANSWER: E
73.
The normal concentration of lactate in blood is:
A.
4,4-6,6 mmol/l
B.
3,3-5,5 mmol/l
C.
4,4-5,5 mmol/l
D.
5,5-6,6 mmol/l
E.
1-2 mmol/l
ANSWER: E
74.
The products of sucrose decomposition in the intestine are:
A.
Glucose, galactose
B.
Fructose, galactose
C.
Maltose, ribose
D.
Ribose, glucose
E.
Glucose, fructose
ANSWER: E
75.
The products of lactose decomposition in the intestine are:
A.
Glucose, fructose
B.
Fructose, galactose
C.
Maltose, ribose
D.
Ribose, glucose
E.
Glucose, galactose
ANSWER: E
76.
How many ATP molecules are formed with complete oxidation of glucose
in aerobic condition?
A.
2
B.
8
C.
42
D.
30
E.
38
ANSWER: E
77.
The process of glucose oxidation in anaerobic condition is:
A.
Glyconeogenesis
B.
Glycogenolysis
C.
Glycogenogenesis
D.
Lipolysis
E.
Glycolisis
ANSWER: E
78.
The end produtcs of aerobic glucose oxidation:
A.
Lactic acid
B.
CO2 and H2O
C.
Ethanol
D.
Acetaldehyde
E.
Pyruvate
ANSWER: E
79.
The concentration of glucose in the blood is normal. Which of the
below-mentioned index proves this?
A.
3-10 mmol/l
B.
4-8 mmol/l
C.
10-15 g/l
D.
1-2 mmol/l
E.
3,3-5,5 mmol/l
ANSWER: E
80.
The sequence of glucose oxidation to lactate in peripheral tissues,
delivery of lactate to the liver, formation of glucose from lactate in the
liver, and delivery of glucose back to peripheral tissues is known as the
______.
A.
Glyoxylate cycle
B.
Kreb's cycle
C.
Gluconeogenesis cycle
D.
None of the above
E.
Cori cycle
ANSWER: E
81.
At starvation how long in humans glycogen store in a liver may be
used?
A.
10 minutes
B.
4 hours
C.
1 week
D.
2 weeks
E.
24 hours
ANSWER: E
82.
What is the prosthetic group of transketolase?
A.
Biotin
B.
Pyridoxal phosphate
C.
NAD+
D.
FAD
E.
Thiamine pyrophosphate
ANSWER: E
83.
A basic role in digestion of carbohydrates in a digestive tract
belongs to following enzymes:
A.
Alfa-amylase, hexokinase, lactase
B.
Maltase, sucrase, enterokinase
C.
Sucrase, maltase, glycogen phosphorylase
D.
Aldolase, glucokinase, beta-amylase
E.
Lactase, alfa-amylase, sucrase
ANSWER: E
84.
Enzymes that are activated by proteolytic cleavage are referred to
as __________.
A.
Covalently modified enzymes
B.
Enzyme complexes
C.
Polymerized
D.
Free radicals
E.
Zymogens
ANSWER: E
85.
An enzyme without its required co-factor prosthetic group is
referred to as the____________________.
A.
Cenzyme
B.
Apoenzyme
C.
Izoensymes
D.
None of the above
E.
Holoenzyme
ANSWER: E
86.
What component is not included in the structure of holoenzymes?
A.
Apoenzyme
B.
Coenzyme
C.
Cofactor
D.
Prostetic group
E.
Izoenzyme
ANSWER: E
87.
A.
B1
B.
B2
C.
B5
D.
B12
E.
С
ANSWER: E
Which vitamin does not serve as a coenzyme?
88.
A.
Na
B.
Zn
C.
Mo
D.
Mn
E.
Fe
ANSWER: E
An ions of what metal do
porphyrine coenzymes contain?
89.
Temperature optimum of enzymes - is:
A.
Temperature which causes denaturation of enzymes
B.
A velosity of reaction at the temperature 48-560С
C.
The best conditions for bringing together of enzyme and substrate
D.
Temperature at which metabolic processes are inhibited
E.
Temperature at which speed of enzymatic reaction is maximal
ANSWER: E
90.
The term ligase refers to a class of enzymes that
catalyzes_________.
A.
Oxidation reduction reactions
B.
Reactions involving the transfer of a functional group from one molecule to
another
C.
Hydrolytic cleavages
D.
All of the above
E.
Reactions where two molecules are joined together
ANSWER: E
91.
During electrophoresis of LDH in blood serum was found out
predominance of LDH1 and LDH2 content. Pathology of what organ does it
testify?
A.
Lungs
B.
Liver
C.
Muscles
D.
Spleen
E.
Heart
ANSWER: E
92.
What from the below mentioned enzymes is a polyenzyme complex?
A.
Transketolase
B.
Succinate dehydrogenase
C.
Aldolase
D.
Glucose-6-phosphatase
E.
Pyruvate dehydrogenase
ANSWER: E
93.
Enzymes:
A.
Are composed of polypeptides
B.
Can bind prosthetic groups such as metal ions that participate in enzyme
reactions
C.
Have defined structures
D.
Bind their substrates at active sites
E.
All statements are true
ANSWER: E
94.
During a gastric secretion proteolytic enzymes are secreted as
proenzymes. What enzyme is activated by hydrochloric acid:
A.
Trypsinogen
B.
Amylase
C.
Lipase
D.
Chymotrypsinogen
E.
Pepsinogen
ANSWER: E
95.
The protective function of saliva is predefined a few mechanisms,
including presence of enzyme, which has a bactericidal action, causes the
lysis of polysaccharide complex of membranes of staphylococcuss,
streptococci. Name this enzyme.
A.
Beta-glyucuronidase
B.
Alfa-amylase
C.
Oligo-1,6-glucosidase
D.
Collagenase
E.
Lysozyme
ANSWER: E
96.
In blood of patient were found out the increase of LDH 4,5, AlAT,
carbamoyl ornithine transferase activity. In which organ is it possible
development of pathological process?
A.
In a cardiac muscle (the heart attack of myocardium is possible)
B.
In skeletal muscles
C.
In kidneys
D.
In connective tissue
E.
In a liver (hepatitis is possible)
ANSWER: E
97.
The list of cofactors which are able to carry electrons and protons
in the process of fermentative reactions is below named, except of one
cofactor which carries chemical groups only. Choose it:
A.
NAD
B.
FAD
C.
Ubiqinon (coenzyme Q)
D.
Hem coenzymes
E.
Pyridoxal phosphate
ANSWER: E
98.
The laboratory test allows to diagnose myocardium infarction. The
increase of what enzyme in blood proves it?
A.
LDH4,5
B.
Arginase
C.
Pyruvate dehydrogenase
D.
ALAT
E.
AsAT
ANSWER: E
99.
In an organism was found the lack of iron. It
of such enzyme activity:
A.
Glutathione peroxidase
B.
Carbonic anhydrase
C.
Carboxy peptidase
D.
Ceruloplasmin
E.
Catalase
ANSWER: E
causes the decrease
100.
The analysis demonstrated a 10 times increase of diastase activity.
The danger of autolysis of a patient’s pancreas is caused by an activation
of enzyme:
A.
Amylase
B.
Pepsin
C.
Lipase
D.
Nuclease
E.
Trypsin
ANSWER: E