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Transcript
Vancomycin Glycopeptide antibiotic Cynthia Tallent Introduction Glycopeptide antibiotic Used to treat gram-positive bacteria Inhibits bacterial cell wall production Resistant strains have been identified Outline History Properties Inhibition of Cell Wall Biosynthesis Resistance Analog Research Review History Discovered in 1956 Originally from Indonesian soil cultures Structure was elucidated in 1983 Structure Properties Administered Intravenously Administered Orally pH 3-5 in aqueous solution P = 2.5 Bacterial Cell Walls Composed of peptidoglycans Help to prevent lysis Gram positive bacteria have thick cell walls Cell Wall Biosynthesis Inhibition of Cell Wall Biosynthesis Vancomycin Resistance Enterococcus and Staphylococcus aureus Changes D-Ala-D-Ala to D-Ala-DLactate Bifunctional model Add Hydrophobic substituents to vancosamine sugar Christopher Walsh Adding Hydrophobic substituents to vancosamine sugar Loss of affinity did not lose antibacterial effect Disaccharide fragments are effective Analogs DCB-PV is effective against Vancomycin Resistant Strains Review