* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Organic Chemistry –Syllabus- one Semester Sackler faculty of
Bottromycin wikipedia , lookup
Woodward–Hoffmann rules wikipedia , lookup
Aromaticity wikipedia , lookup
Marcus theory wikipedia , lookup
Homoaromaticity wikipedia , lookup
Discodermolide wikipedia , lookup
Elias James Corey wikipedia , lookup
Hofmann–Löffler reaction wikipedia , lookup
Enantioselective synthesis wikipedia , lookup
Ring-closing metathesis wikipedia , lookup
George S. Hammond wikipedia , lookup
Baylis–Hillman reaction wikipedia , lookup
Diels–Alder reaction wikipedia , lookup
Wolff rearrangement wikipedia , lookup
Aromatization wikipedia , lookup
Asymmetric induction wikipedia , lookup
Ene reaction wikipedia , lookup
Stille reaction wikipedia , lookup
Organosulfur compounds wikipedia , lookup
Hydroformylation wikipedia , lookup
Wolff–Kishner reduction wikipedia , lookup
Petasis reaction wikipedia , lookup
Physical organic chemistry wikipedia , lookup
Organic Chemistry –Syllabus- one Semester Sackler faculty of medicine Tel-Aviv University-Israel CONTENTS: Electronic Structure and Bonding, Acids and Bases The Structure of an Atom, The Distribution of Electrons in an Atom, Ionic, Covalent, and Polar Bonds, Lewis Structures, Skeletal Structure (Line-Bond Structure), Formal Charge, Bond strength, Bond length, Hybridization(sp3, sp2, sp), geometry of molecules, Dipole Moment, Functional Groups , Resonance, Acids and Bases: The Brønsted-Lowry Definition, conjugation acid-base pair, Ka ,pKa ,Kb, how to determine the position of acid-base reaction, The Effect of Structure on pKa, The Henderson–Hasselbalch Equation, A buffer Solution, Lewis Acids and Bases. Organic Compounds + Alkanes double bond equivalent, alkyl group, Nomenclature (IUPAC rules), intermolecular forces( van der Waals force, Dipole–dipole interaction, Hydrogen bonds), Solubility, Conformations of alkanes(staggered-eclipsd) , Cycloalkanes, geometric isomers, The chair conformation of cyclohexane, Combustion of alkanes, Oxidation and Reduction in Organic Chemistry, Halogenation of alkanes. Stereochemistry Classification of Isomers, Chirality, Enantiomers, Achiral molecules, chirality center, Meso compounds, Naming Enantiomers ( R,S configurations), Fischer Projection, Optical Activity, Racemic Mixture, Diastereomers, Resolution of a Racemic Mixture, Discrimination of Enantiomers by Biological Molecules. Substitution and Elimination reactions substitution and elimination reactions- definitions, Thermodynamics and Kinetics (activation energy, transition state, intermediate product, reaction order, Catalysis, free energy, exergonic and endergonic reaction reaction), Mechanism of an SN2 Reaction, Nucleophilicity, Mechanism of an SN1 Reaction, rearrangement, Mechanism of an E1 and E2Reactions, SN2- SN1 conditions, Competition Between Substitution and Elimination, Williamson ether synthesis, SAM Reagent. Alcohols and Ethers Converting Alcohols into Alkyl Halides, Dehydration of Alcohols, Alcohol oxidation, Acid-base catalyzed ring-opening of epoxides, Grignard Reagents, Biological Oxidants and Reductants. 2 מתוך1 עמוד Alkenes Nomenclature , Structure and Properties, Addition of Hydrogen Halides, Markovnikov’s Rule, Addition of Water, Addition of Halogens, addition of A Peroxyacids to an Alkene, Hydroboration, anti-Markovnikov addition of HBr, Addition of Hydrogen, Relative Stabilities of Alkenes, Ozonolysis, reaction of alkene with KMnO4. Alkynes and Dienes Nomenclature , Structure and Properties, Addition of Halogens and Hydrogen to alkynes, Addition of Water (Markovnikov and anti-Markovnikov), complete hydrogenation of alkyne, Lindlar Reduction, Reduction With Na or Li, alkylation. Dienes: 1,2 and 1,4 additions of Conjugated Dienes, Thermodynamic Versus Kinetic Control, The Diels–Alder Reaction. Carboxylic acid derivatives Nomenclature , Structure and Properties, Addition-Elimination Mechanism, Reactions of Acyl Halides, Reactions of Acid Anhydrides, Reactions of Esters, Ester Hydrolysis, Fischer esterification, reaction of amides and carboxylic acids, Hydrolysis of Nitriles, Activation of Carboxylic Acids, Dicarboxylic Acids, Reaction of esters, acyl halides and Nitriles with Grignard Reagents, reduction of esters, carboxylic acids, acyl halides , amides and nitriles. Aldehydes and Ketones + Reactions at the α-Carbon Nomenclature , Structure and Properties, Reactions of Aldehydes and Ketones with Grignard Reagents, cyanide ion, acetylide ion, hydride and Nitrogen Nucleophiles. Reductive amination, reduction of ketones to alkanes, ketones oxidation, Reactions of Aldehydes and Ketones with water and Alcohols. Reactions at the α-Carbon: Acidity of α –Hydrogens, Keto–Enol Tautomerism, Halogenation of the α -Carbon of Aldehydes and Ketones, Enolization, Alkylation of the α -Carbon of Carbonyl Compounds, The Michael Reaction, aldol condensation, Claisen Condensation, Dieckmann condensation, Decarboxylation, The Malonic Ester Synthesis, The Acetoacetic Ester Synthesis, A Biological Aldol and Claisen condensations, Fatty acid biosynthesis. Aromatic compounds Aromaticity, Nomenclature , Structure and Properties, Electrophilic Aromatic Substitution Reactions, Halogenation, Nitration, Sulfonation, Friedel–Crafts Acylation, Friedel–Crafts Alkylation, activating and deactivating substituents, ortho– para directors, meta directors, Reducing a Nitro Substituent, oxidation of Alkyl Substituents. If time allows we will learn in general some of the following topics: Proteins, carbohydrates, nucleic acids, lipids, metabolic pathways, Identification of organic compounds (UV, IR, MS, NMR), Drugs. Bibliography: 1.Organic chemistry,P. Bruice, 6th edition. 2.Organic chemistry, J. McMurry, 8th edition. 3. Fundamentals of Organic Chemistry,J. McMurry, 7th edition. 2 מתוך2 עמוד