Download Course: Immunopathology and Immunotherapeutics

Course: Immunopathology and
Immunotherapeutics
By Dr. Sheeba Murad Mall
Recommended Books
 Essentials of Clinical Immunology by
Helen Chapel, Mansel Haeney, Siraj
Misbah and Neil Snowden
 Immunology by Kuby, 2011
 Basics in Immunology by Lichtmann
and Abdul Abbass
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The basis of immunology, Antigen recognition and response of immune system
Tolerance: immunological principles of tolerance: central versus peripheral tolerance, role of
regulatory T cells, natural killer T cells, dendritic cells
Primary immunodeficiencies of lymphocytes, phagocyte disorders, complement disorders
Proliferation disorders of immunologic cells: lymphomas, plasma cell eosinophilia, mastocytosis
Systemic disorders with immunopathologic key mechanisms: rheumatoid arthritis, systemic lupus
erythematosus, rheumatic fewer and other conditions
Organ specific immunopathology: diabetes melitus, autoimmune thyroid disease, myastenia gravis,
multiple sclerosis, autoimmune hemolytic anemia
Allergic diseases: asthma, anaphylactic syndrome, insect venom allergy –
Immune evasion mechanisms in infections: Tuberculosis, EBV-infection, Lyme disease
Autoimmune response and immune tolerance, Priming regulatory t cells and antigen specific
suppression of autoimmune diseases, Peripheral t cell regulation and autoimmunity, Antiergotypic
regulation of immune response
Immune mediated inflammatory disorders: role of TNF, role of other inflammatory pathways,
identification of therapeutic targets
Allergy and asthma: role of inflammatory cells and immune cells; role of mediators; therapeutic
targets
Immunotherapy: overview of immunotherapies (small molecules, biologicals): principles,
indications, side effects: T cell therapy, Non-T cell therapy, Use of dendritic cells in immunotherapy ,
heat shock proteins
Solid Tumor Immunology and immunotherapy
• First sessional 20%
• Second sessional 20%
• Quiz and Assignment 10%
• Terminal 50%
The basis of immunology, Antigen
recognition and response of immune
system
Terms in
relation to
Immunity
•Immunity is defined as resistance to
disease
•“Immunity” derives from the latin word
immunis , meaning exemption from military
service, tax payments or other public
services
•The state of exemption or protection from
infectious disease
•The collection of cells, tissues and
molecules that mediate resistance to
infections is called an immune system
•The study in relation to the immune system
is termed as Immunology
•The coordinated reaction of these cells
and molecules to infectious microbes is the
immune response
• The immune system recognizes infection and induces
protective responses:
immunological recognition
immune effector functions
Immune regulation
immunological memory
Lymphoid organs
Basic terms used in Immunology
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Innate immunity
Adaptive immunity
Humoral immunity
Cell-mediated immunity
Antigen
Epitope
Hapten
Superantigen
TLR
PRRs
MHC molecules
Immunological memory
Antigen presenting cells