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Transcript
ISLET-1+ HEART PROGENITORS: A PARABLE OF REGENERATIVE CARDIOVASCULAR MEDICINE Kenneth R. Chien Cardiovascular Disease Program, Harvard Stem Cell Institute Cardiogenesis requires the formation of a diverse spectrum of muscle and non-muscle cell lineages in specific tissue compartments of the heart. Regenerative stem cell therapies for heart disease necessitate a deep understanding of the molecular mechanisms that govern the fates and differentiation of cardiovascular precursor cells during development. Recent studies have now revealed that different cardiac cell types arise from a common multipotent Isl1+ progenitor. This clonal model of heart lineage diversification would be analogous to hematopoiesis, in which a single hematopoietic stem cell can generate all of the blood cell lineages. The ability to isolate, renew and differentiate Isl1+ precursors from post-natal/embryonic hearts and from ES cells represents a powerful cell-based system which allows the characterization of signaling pathways controlling formation, renewal and lineage specification of cardiovascular progenitors.