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WHAT LIMITS CELL SIZE? 1. DIFFUSION: Diffusion is a fast and efficient process over short distances, however becomes slow and inefficient as distance increases Ex: mitochondria at center of very large cell – can’t get necessary nutrients from diffusion 2. DNA LIMITS CELL SIZE: Blueprints for proteins cannot be copied in the nucleus and made into proteins in the cytoplasm quickly enough 3. SURFACE AREA TO VOLUME RATIO: As cell’s size increases, volume increases much faster than surface area *Ex: Plasma membrane may not have enough surface area through which oxygen, nutrients, and wastes could diffuse -Cell would either starve to death or be poisoned by buildup of wastes