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implemented in SOLVE/RESOLVE (42). During the course of model building and refinement, the stereochemistry of the structures was checked by PROCHECK (22). The final statistics are provided in Table 2. Surface electrostatic potentials were calculated using DELPHI (30). All figures were generated using Pymol (10) and Espript (15). The coordinates for the molecules were deposited into the PDB with accession numbers 2GE7 (CTD1), 2GE8 (CTD2), 2CA1 (CTD3) and 2GEC (NTD1). Acknowledgements This work was supported by grants from the NIH (AI36040), and the Robert Welch Foundation to BVVP, and grants from the Singapore Biomedical Research Council (03/1/22/17/220) and the Academic Research Fund (RG119/05) to JL. We thank Jennifer Falon and Florante Quiocho for use of in-house X-ray diffraction facility at BCM. HJ wishes to thank Chris Miller and HHMI for support during the latter half of this project. We acknowledge use of the SBC-CAT 19ID and BIOCARS BM14 beam line and its staff for their help during data collection at the Advanced Photon Source supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Science, under Contract No. W-31109-Eng-38. 17
