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Transcript
Bovine amyloidotic spongiform encephalopathy (BASE) is one of the recently discovered atypical forms of BSE,
which is transmissible to primates, and may be the bovine equivalent of sporadic Creutzfeldt–Jacob disease
(CJD) in humans. Although it is transmissible, it is unknown whether BASE is acquired through infection or
arises spontaneously. In the present study, the gene expression of white blood cells (WBCs) from 5 cattle at 1 yr
after oral BASE challenge was compared with negative controls using a custom microarray containing 43,768
unique gene probes. In total, 56 genes were found to be differentially expressed between BASE and control
animals with a log fold change of 2 or greater. Of these, 39 were upregulated in BASE animals, while 17 were
downregulated. The majority of these genes are related to immune function. In particular, BASE animals
appeared to have significantly modified expression of genes linked to T- and B-cell development and activation,
and to inflammatory responses. The potential impacts of these gene expression changes are described