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28-Aug-2014 9:20 AM
Topic: Health
NuGEN Introduces Target Enrichment Technology for
Comprehensive Detection of Gene Fusion Events in
Oncology Research and Clinical Testing
~Most Complete NGS Target Enrichment Solution for the Detection of Gene Fusion Events Enabled in a
Simple and Rapid Workflow~
SAN CARLOS, Calif.--(BUSINESS WIRE)--NuGEN Technologies, Inc., a market leader in the development of
solutions for Next Generation Sequencing (NGS) applications, has announced the release of a novel targeted
enrichment method that, in a single assay, will detect all possible fusion events involving 446 cancer fusion genes as
curated by the Wellcome Trust Sanger Institute's Catalog of Somatic Mutations in Cancer (COSMIC). The
proprietary NuGEN technology uses a unique single primer strategy that requires only one partner exon to be
targeted, thereby enabling not only detection of known fusion events but also discovery of novel gene fusions and
alternative splice forms.
“Screening samples for a broad range of gene fusions has been a costly and time consuming process until now”
NuGEN's proprietary Single Primer Enrichment Technology (SPET) is the core technology that delivers a highly
sensitive method for detection of low abundance gene fusion transcripts with as little as 10 ng of total RNA derived
from either fresh or formalin-fixed paraffin-embedded tissues. The easy, cost-effective assay employs a single day,
rapid workflow.
“Screening samples for a broad range of gene fusions has been a costly and time consuming process until now,”
commented Doug Amorese, VP of R&D at NuGEN. “The SPET technology for targeted RNA sequencing enables
NGS analysis to identify any fusion event in the targeted gene set and will be an important approach both in basic
research and the development of RNA-Seq based cancer diagnostic and prognostic tests.”
The Ovation Fusion Panel Target Enrichment System queries 5769 exons and is available with 8, 32 and 96
barcodes for efficient library generation and cost effective sequencing analysis.
In addition, customized gene fusion panels using the same technology can also be made to specific user
requirements. “We are actively working with partners who are currently using the standard Ovation Fusion Panel
Target Enrichment System in clinical research programs and anticipate moving forward with custom designed fusion
panels for use in clinical testing in the future,” said Joe Don Heath, NuGEN's Vice President of Diagnostic Market
Development. NuGEN offers custom design services for target enrichment products with a three week turnaround
from design to delivery and has an active diagnostic partner program for the supply of sample preparation
technology.
About NuGEN
NuGEN Technologies is a San Carlos, CA company focused on innovative solutions for RNA and DNA that enable
life scientists to do more with less. With reagent solutions that are quick, easy to use, and amenable to automation,
NuGEN empowers researchers and clinicians to prepare genomic samples of any size, from almost any source,
regardless of the intended application or technology platform. For more information please visit www.nugen.com.
Ovation and NuGEN are registered trademarks of NuGEN Technologies, Inc.
Contacts
NuGEN Technologies, Inc.
Carol Short, 650-590-3002
[email protected]
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