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ALLELIC DIVERGENCE PRECEDES AND PROMOTES GENE DUPLICATION
Stephen R. Proulx, Patrick C. Phillips, and L. Katz
Evolution May 2006 : Vol. 60, Issue 5, pg(s) 881-892 doi: 10.1554/05-507.1
Abstract & References
ALLELIC DIVERGENCE PRECEDES AND PROMOTES GENE DUPLICATION
CLOSE
Stephen R. Proulx
Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon
97403 [email protected]
Stephen R. Proulx
and
CLOSE
Patrick C. Phillips
Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon
97403
Patrick C. Phillips
L. Katz
The Society for the Study of Evolution
Received: September 6, 2005; Accepted: February 23, 2006
[+] Author & Article Info
Author Affiliations
Stephen R. Proulx1
Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon
97403 [email protected]
Patrick C. Phillips
Center for Ecology and Evolutionary Biology, 5289 University of Oregon, Eugene, Oregon
97403
Copyright & Usage
The Society for the Study of Evolution
Abstract
One of the striking observations from recent whole-genome comparisons is that changes in the
number of specialized genes in existing gene families, as opposed to novel taxon-specific gene
families, are responsible for the majority of the difference in genome composition between major
taxa. Previous models of duplicate gene evolution focused primarily on the role that neutral
processes can play in evolutionary divergence after the duplicates are already fixed in the
population. By instead including the entire cycle of duplication and divergence, we show that
specialized functions are most likely to evolve through strong selection acting on segregating
alleles at a single locus, even before the duplicate arises. We show that the fitness relationships
that allow divergent alleles to evolve at a single locus largely overlap with the conditions that
allow divergence of previously duplicated genes. Thus, a solution to the paradox of the origin of
organismal complexity via the expansion of gene families exists in the form of the deterministic
spread of novel duplicates via natural selection.
Keywords: Gene duplication, heterozygote advantage, natural selection, multigene family,
polymorphism
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1
Present address: Department of Ecology, Evolution and Organismal Biology, Iowa State
University, 253 Bessey Hall, Ames, Iowa 50011
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