Download Point Mutations

Bell Work
tRNA’s anticodons are complementary
to mRNA’s codons when they meet in
the ribosome, why is it important that
they are the exact complement?
Test Thursday!
Cut out the notes and glue
them on page 43
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End
Title: Mutations
Page:43
Date: 10/26/15
Standard: Identify and Illustrate changes in DNA
and evaluate the significance of these
changes
EQ: How Do Mutations of DNA Affect the
Outcome of a Protein?
Mutations: changes in the genetic material
caused by mistakes during replication,
Resistance to HIV
transcription, or due to environmental factors
(radiation)
Crystal clear underwater vision!
Crystal clear underwater vision
Sickle Cell Anemia
Color Blindness
Two major types of mutations:
Point Mutations
(substitutions)
A mutation that
changes a single base
Frameshift Mutations
An insetion or
deletion that affects
the entire amino acid
sequence
Normal DNA
DNA
mRNA
Phe
Tyr
Ala
Arg
Point Mutation
Silent:
DNA
mRNA
Phe
Tyr
Ala
Arg
Even though a base
changes, it does
not cause a change
in the amino acids
Point Mutation
Missense:
DNA
mRNA
Phe
Tyr
Gly
Arg
A base change
causes a change in
one amino acid
Point Mutation
Nonsense:
DNA
mRNA
Phe
Stop Ala
Arg
A base change
causes an early
stop
Frameshift Mutation
Insertion:
DNA
mRNA
Phe
Iso
Cys
Thr
A base is added
and causes a
change in all the
amino acids after it
Frameshift Mutation
Deletion:
DNA
mRNA
Phe
Leu
His
A base is deleted
and causes a
change in all the
amino acids after it
Box new base RED
Color new codons Green
Color New amino acids purple or blue
Quick Write (notecard):
Which is more likely to have a
bigger effect on an organism, a
point mutation or frameshift
mutation? Explain why.