Download JOHN MASON PAWELEK, Ph

JOHN MASON PAWELEK, Ph.D.
Curriculum Vitae
Education:
Diploma
A.B.
Ph.D.
Baltimore Polytechnic Institute,
Baltimore, MD
Gettysburg College, Gettysburg, PA
Brown University, Providence, RI
1959
1963
1967
Positions:
1967-70
Postdoctoral Fellow, American Cancer Society. Dr. Peter Lengyel, Yale
University, Project-Initiation of Eukaryotic Protein Synthesis
1970-71
Research Associate. Dr. Paul Howard-Flanders Yale University,
Project-Genetic Control of DNA Synthesis in Escheriscia coli
1971-77
Assistant Professor of Dermatology, Yale University
1977-82
Associate Professor of Dermatology, Lecturer in Molecular Biophysics and
Biochemistry, Yale University School of Medicine
1982-2005
Senior Research Scientist in Dermatology, Yale University School of Medicine
1984-2003
Lecturer in Pharmacology, Yale University School of Medicine
2005-current Research Affiliate, Dept. of Dermatology and the Yale Cancer Center, Yale
University School of Medicine
2006
Visiting Research Fellow, Gettysburg College, Gettysburg, PA
2007
Member, Scientific Advisory Board, Playtex Sun Care Products
2007-2008
Associate Fellow, Biology, Gettysburg College, Gettysburg, PA
2007-current Consultant in Pigmentation Research, Access Business Group, Ada, MI
2007-current Member, Scientific Advisory Board, Artistry Inc.
Awards and Other Professional Activities:
1967
1983-85
1984
1985-88
1992-00
1993
1998
1999
2000
2002
2004
2005-08
2005-08
2005-08
2006-
Barry Rosen Memorial Award (Inaugural Brown University Graduate Research
Award)
Lawrence M. Gelb Research Fellowship
Skin Cancer Foundation Award
Board of Trustees, International Pigment Cell Society
Council Member (3 times), Pan American Society for Pigment Cell Research
Inaugural Award: Henry Stanley Raper Medal (for biochemistry of mammalian
pigmentation), Internat Fed Pigment Cell Societies
Gelb lecturer, Pan Amer. Soc. Pigment Cell Research
Outstanding Alumnus Award, Gettysburg College, Gettysburg, PA
Career Achievement Award, Pan Amer. So. Pigment Cell Res
President-Elect, Pan Amer. Soc. Pigment Cell Research
Aaron B. Lerner Award for Excellence in Pigment Cell Research, PanAmerican
Society for Pigment Cell Research
President, Pan American Society for Pigment Cell Research
Council, International Federation of Pigment Cell Societies
Steering committee, Society for Melanoma Research
Associate Editor, Cell Adhesion and Migration
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2008
20082010
2011
2011
2011-
Takeuchi Medal for discovery of dopachrome tautomerase. Japanese Society for
Pigment Cell Research/IFPCR, Sapporo, Japan, 5/8/08.
Associate Editor, Melanoma Research
Named lectureship: “The John M. Pawelek Lectureship”, initiated at 4th
Annual Meeting of the ASPCR, Guangzhou, China. (Endowed by Amway, Inc.)
Invited Lecture at same meeting: “Pigmentation yesterday, today, and tomorrow”
Calicut, India, 01/11
Invited Lecture at same meeting: “Pigmentation yesterday, today, and tomorrow”
Named lectureship: “The John M. Pawelek Lectureship”, 5th Annual Meeting of
the ASPCR, with the World Congress of Dermatology, Seoul, S. Korea 07/11.
(Endowed by Amway, Inc.)
Invited Lecture at same meeting: “Leucocyte-tumor cell fusion in a human
melanoma brain metastasis”
Council Member, PanAmer. Soc Pigment Cell Research
Patents Issued and Pending in Following Areas:
Cosmetic Synthetic Melanins
Treatment for Skin Hypo- and Hyperpigmentation
Vectors for the Diagnosis and Treatment of Cancer
Targeting Glycoconjugates on Metastatic Tumors
Glycosylation and Cutaneous Pigmentation
Professional Societies:
Society for Investigative Dermatology
International Federation of Pigment Cell Societies
Pan American Society for Pigment Cell Research
Metastasis Research Society
American Association for Cancer Research
Society for Melanoma Research
Teaching:
MBB 210a, Molecular Genetics II
Anatomy 119a, Techniques in Developmental Biology
MBB 710a, Molecular Genetics of Eukaryotes
MBB 101a, Introduction to Biochemistry
Pharmacology 503a, Molecular Mechanisms of Hormone Action
Cell Biology 619a/Pharmacology 570a, Cell Regulation
Pharmacology 502b, Graduate Seminar, Receptors and
Second Messengers
Minority Student Research Programs: Mentor
Lab mentor: medical, graduate, undergraduate students
Lecturer, Gettysburg College, Cell Biology Course
Miscellaneous:
1975 - Invited Speaker
1976 - Invited Speaker
American Academy of Dermatology
Gordon Research Conference of cyclic AMP
2
1971-1983
1972-1973
1973-1978
1976
1980-1986
1987-1990
1990-1992
1990-current
1971-current
2006-
1977 - Invited Speaker
1977 - Plenary Lecturer
1979 - Invited Speaker
1980 - Invited Speaker
1981 - Invited Speaker
1981/1982-Faculty
1983 - Invited Speaker
1984 - Invited Lecturer
1985 - Session Chairman,
Invited Speaker
1985 - Invited speaker VI
1986 - Session Chairman,
Invited Speaker
1987 - Invited Speaker
1987 - Invited Speaker
1987 - Invited Speaker
1988-Invited Guest Lecturer
1989 - Invited Speaker
International Congress of Dermatology
Mexico City, Mexico
10th Annual Meeting of the Japanese
Pigment Cell Club, Sendai, Japan
American Academy of Dermatology
Chicago Dermatological Society
Cold Spring Harbor Conferences on Cell Proliferation
Cold Spring Harbor Course on Cell Proliferation
Gordon Research Conference on Hormone Action
Jagiellonian University, Krakow, Poland
Gdansk University, Gdansk, Poland
Silesian Medical Academy, Sosnowiec, Poland
Charles University, Prague, Czechoslovakia
First International Conference on Skin Melanoma,
Venice, Italy (World Health Organization)
European Workshop on Melanin Pigmentation
Murcia, Spain
International Pigment Cell Conference, Tucson, Arizona
Second European Congress of Photobiology, Padova, Italy
European Pigment Cell Society, Sorrento, Italy
Society of Cosmetic Chemists, Dallas, Texas
Trinity College Course on Photobiology, Hartford, CT
Gettysburg College Senior Biology Honors Day,
Gettysburg, PA
1989 - Invited Speaker
Oberlin College Monte-Block Lecturer in Biology,
Oberlin, OH
1989 - Plenary Lecturer
Second International Conference on Skin Melanoma
Venice, Italy (World Health Organization)
1989 - Invited speaker U.S. Environmental Protection Agency Seminar on "Health
Effects of UV Radiation", Washington, DC
1990 - Session Chairman,
XIVth International Pigment Cell Conference,
Invited Speaker
Kobe, Japan
1990 - Invited Speaker
Symposium “Molecular Biology of Pigment Cells”,
Sendai, Japan
1991 - Invited Speaker
Oberlin College Senior Biochemistry Students, Oberlin, OH
1991 - Plenary Lecturer
PanAmerican Society for Pigment Cell Research,
Edmonton, Canada
1991 - Invited Speaker
Dermal Clinical Evaluation Society, Princeton, NJ
1991 - Plenary Lecturer
European Society for Pigment Cell Research,
Amsterdam, The Netherlands
1992 - Invited Speaker
10th Anniversary Symposium, Center for Alternatives to
Animal Testing, Johns Hopkins University, Baltimore, MD
1992 - Invited Speaker
20th Annual Meeting, American Society for Photobiology,
Marco Island, FL
3
1992 - Invited Speaker
Williamsburg Mini-Conference on Regulation of
Melanogenesis, Williamsburg, VA
1992 - Invited Speaker
“Skin Color”, Cheshire High School, Cheshire, CT
1992 - Podium Speaker
European Society for Pigment Cell Research,
Berlin, Germany
1993 - Podium Speaker
International Pigment Society, London, England
1993-96 - Lecturer
Institute for Science Instruction and Study, Southern
Connecticut State University, New Haven, CT
1994 - Lecturer
“Cancer” Dodge City Community College, Dodge City, KA
1995- Tutorial Presentation Conference on “Paradigms in Cancer Biology and Cancer
Therapy”, Krasnow Institute for Advanced Study,
George Mason University, Fairfax, Virginia
1996-Cancer Grand Rounds "Mechanisms of Melanoma Metastasis" Yale Cancer Center,
New Haven, CT
1997- Invited Speaker Santa Barbara Cancer Foundation Workshop,
“Cancer as an Evolutionary Phenomenon”
1997-Invited Speaker
“Colors in Nature” Troup Magnet Academy of Sciences, 7th grade
New Haven, CT
1997- Invited Speaker National Cancer Institute lecture “Melanoma/Macrophage Fusion
Hybrids as Models for Solid Tumor Metastasis”
1997-Podium Speaker International Conference on Melanoma, Sydney, Australia
1997-Podium Speaker Symposium on Pigmentary Disorders from a Global Perspective,
Bali, Indonesia
1997-Current
New Haven Inner City Youth Counselor, Waverly Housing Project
1998-Invited Speaker
Westwoods School/Vincent Mauro School Urban-Suburban Exchange
Program (Hamden/New Haven) "The Colors of Life"
1998-Invited Speaker
Institute for Racial Healing, Groton, CT. "The Fallacy of the Bell
Curve"
1998-Invited Speaker
"Cosmetic Melanin" International Cosmetic Expo, Javitts Center,
NY.
1998-Invited Speaker
Yale University Health Services, Department of Dermatology,
Skin
Cancer Awareness Week
1998-Honorary Lecture
"Gelb Lecture" Pan American Society for Pigment Cell Research,
Aspen, Colorado
1998-Plenary Lecture
European Society for Pigment Cell Research, Prague, Czech
Republic
1998-Workshop Leader
"The Fallacy of the Bell Curve" PEERS (Parents and Educators for
Eliminating Racism in Schools), Groton , CT
1998-Invited Speaker
"Sunlight, Melanin, and Melanoma", Trinity College, Hartford,
CT
1998-Invited Speaker
Spotlight on Research, Animal Resources Center, Yale Medical
School
1998-Cited
US News and World Report, Mar 30, p79, "Cancer: Salmonella
AntiCancer Therapy"
1998-Cited
Forbes Magazine, Nov 16, p240, "Fighting Disease With Disease"
1998-Cited
Journal of the National Cancer Institute, Dec., 1998
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1999-seminar speaker
Pharmacology Department, Yale University School of Medicine
"On the role of N-glycosylation in melanoma metastasis"
1999-Cited
Allure Magazine, March, 1999, p102 "Tan in a Bottle".
1999-Guest writer
Inner City (New Haven CT) "The Songs of the Journey Concert"
April, 1999.
2000-Cited
The Scientist, Feb. 15,2000 Vol 14, No. 4, p8 "The Positive Side
of Salmonella".
2000-Cited
The Scientist, May 29, 2000 vol 14, No. 11, p8 "Tumor
Metastasis by Hybridization".
2000-Author and Co-director "The Spirit of Life" Unitarian Society of New Haven, June, 2000.
2000-Guest writer
Arts! (Arts Council of Greater New Haven) Vol 13: no.9 Oct,
2000 "Paul F. Mueller leads the New Haven Chorale in its 50th
season jubilee"
2000-Cited
Newsweek Magazine, Nov 6, 2000, p86. "Pigment in a Tube."
2001-Cited
New York Times, Science Times, Jan 23, 2001, pF7. "The Evil
Salmonella and Its Helpful Twin".
2001-Author and Co-director "A Strange Evening at St. Thomas" 6th Grade play, St. Thomas
Day School, New Haven, CT, 3/14/01.
2001-Dedication
St. Thomas Day School, New Haven, CT. 2001 Yearbook
Dedication for writing and directing the 6th Grade play.
2001-Speaker
"CANCER!" The Regional Bioscience Consortium, Quinnipiac
Univ. (HS students-Hamden, Cheshire, N.Haven, Wallingford)
5/2/01, Hamden, CT.
2001-Speaker
“Tumor cell/phagocyte hybridization in melanoma metastasis”
Uppsala University Sch of Med., Uppsala, Sweden, 11/15/01
2001-Speaker
“New findings on melanoma pigmentation and progression”.
Yale Dermatology Seminar (with Tamara Handerson, MD)
2001-Speaker
Evergreen Woods Retirement Community: The Big Bang,
Genesis, and Life in this Universe, Branford, CT, 01/10/02.
2002-Speaker
International Federation of Pigment Cell Societies, Beta 1,6Branched N-glycans and coarse melanin in melanoma
progression” The Netherlands, 9/02.
2003-Speaker
Bowdoin College Distinguished Lecturer Series. “Bacteria as
Anticancer Agents”. Brunswick, Maine, 3/03.
2003-Speaker
Norwich Unitarian Church. The Big Bang, Genesis,
and Human Consciousness. Norwich, CT., 3/03.
2003-Speaker
Tumor-hematopoietic cell hybrids and myeloid-type
glycosylation in human cancer: new targets for
therapeutic intervention. Yale Cancer Center Grand
Rounds. New Haven, CT 9/9/03.
2003-Speaker
Tumor-hematopoietic cell hybrids and myeloid-type
glycosylation in human cancer: new targets for
therapeutic intervention. Boston College, Dept. of
Biololgy, Boston, MA. 9/23/03.
2003-Speaker
How Cancer Spreads. Greenwich Rotary Club, Greenwich, CT,
10/8/03
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2003-Speaker
2004-Speaker
2004-Speaker
2004-Speaker
2004-Speaker
2004-Award Lecture
2004-Speaker
2004-Speaker
2004-Clinical Conference
2005-Speaker
2005-Plenary Lecture
2005-Director/Producer
2005-Speaker
2005-Plenary Lecture
2005-Cited
2005-Speaker
2005-Cited
2005-Cited
2006-SMR Commentary
2006-Speaker
“Myeloid-type glycosylation and melanoma progression”
Beeson Lecture Series, Dept. Dermatology, Yale School
Medicine. 12/3/03
Aberrant glycosylation is an independent predictor of metastasis
and poor survival in breast carcinoma. Breast Cancer Research
Conference, Yale Cancer Center. 01/13/04
“Origins of cancer.” Spotlight on Research: Yale Animal Care and
Use Seminar Series. 02/12/04.
“Cancer.” Nursing Program, University of South Dakota, Sioux
Falls, S.D. 02/13/04.
“BMT-tumor hybrids in a renal cell carcinoma”.
Section of Medical Oncology, Yale School of Medicine. 06/04/04.
“Melanoma pigmentation and progression: Some things new under
the sun. Aaron B. Lerner Award Lecture. PASPCR XIIth Annual
meeting. Newport Beach, CA. 6/25/04.
“Tumor-hematopoietic cell fusion as a mechanism for solid tumor
metastasis.” Amgen, Inc., Seattle, WA. 9/28/04.
Macrophages target 1,6-branched oligosaccharide-producing cells
in human melanomas. 2nd International Melanoma Research
Conference. Phoenix, AZ. 11/15/04.
Macrophages target 1,6-branched oligosaccharide-producing cells
in human melanomas. Clinical Melanoma Conference, Yale
School of Medicine. 12/2/04
First meeting of the Asian Society for Pigment Cell Research.
“Coarse melanin in human melanoma.” New Delhi, India, 2/2/05
“Funding Creative Science: Who pays outside the box?” National
Council of Univ. Res. Administrators Region I, Mystic, CT, 5/05
“Yanomamo”, Unitarian Society, Hamden, CT, 6/05
“Mentors and Miracles” St. Thomas’s Day School Graduation, New
Haven, CT, 6/05
“Salmonella and Bordetella for targeting and destruction of tumor
cells” Life Engineering Conf. National Academies/Keck
Futures Initiative. San Francisco, CA. 8/19/05.
San Francisco Chronicle “Science Tweaks Nature’s Toolbox”
8.20/05.
“Langerhans cells expressing 1,6-branched oligosaccharides are
enriched in vitiligo perilesional skin.” International Pigment Cell
Conference, Reston, VA, 9/22/05.
Boston Globe “When researchers are guinea pigs” 12/12/05
New Haven Register “Research supports century-old theory on
cancer spread” 11/30/05
“Viewing malignant melanoma cells as macrophage-melanoma
fusion hybrids” Spring, 2007.
Tumor cell fusion with macrophages promotes metastasis”
Jake Gittlen Cancer Research Foundation, Penn State University,
Hershey Medical Center, Hershey, PA 02/23/06.
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2006-Speaker
2007-Speaker
2007-Speaker
2007-Speaker
2007-Speaker
2007-Speaker
2007-Keynote Lecture
2007-SMR newsletter
2007-Speaker
2008-Speaker
2008-Award
2008-Speaker
2008-Cited
2009-Cited
2009-Lecture
2009-Lecture
2009-Keynote Lecture
2009-Invited Lecture
Understanding cancer: A scientific journey from Gettysburg to
Yale (and back). The Robert D. Barnes Memorial Honors Lecture.
Gettysburg College, Gettysburg, PA. 04/18/06
Cancer cell fusion with migratory bone marrow-derived cells: A
unifying explanation for metastasis. Human Medical Genetics
Program, University of Colorado, Aurora, CO. 02/01/07
Cancer cell fusion with migratory bone marrow-derived cells: A
unifying explanation for metastasis. City of Hope National Cancer
Center, Duarte, CA. 04/02/07.
Cancer cell fusion with migratory bone marrow-derived cells: A
unifying explanation for metastasis. Garden State Cancer Center,
Belleville, NJ, 05/21/07.
Aberrant glycosylation in melanoma and vitiligo. 2nd Annual
Meeting of the Asian Society for Pigment Cell Research,
Singapore, July 6-8, 2007.
“The pathology of melanoma progression: Cell fusion as an
explanation.” Linköping University, explanation. Linköping,
Sweden, 3 October 2007.
“Cancer cell fusion with migratory bone marrow-derived cells: A
unifying explanation for metastasis 1st Conference on cell fusion
and cancer”, Söderköping, Sweden, 4-5 October, 2007
“GnT-V and 1,6-branched oligosaccharides in melanoma.” 9/07.
“The pathology of melanoma progression: Cell fusion as an
explanation.” Comprehensive Cancer Center, Univ. Michigan, Ann
Arbor, MI. 11/27/07
Cancer as an evolutionary disease. Lutheran Theological Seminary
at Gettysburg. Gettysburg, PA. 02/11/08
Takeuchi Medal for discovery of dopachrome tautomerase.
Japanese Society for Pigment Cell Research/IFPCR, Sapporo,
Japan, 5/8/08.
"Cancer Cell Fusion with Migratory Bone Marrow-derived Cells as
an Explanation for Metastasis: New Therapeutic Paradigms”
Developmental Therapeutics Res Program Conf. Yale School of
Medicine 10/23/08
“Cell Fusion Theory: Can it Explain What Triggers Metastasis?
Andrea Carter JNCI, Sept, 2008
“A theory of deadly fusion” Charles Q. Choi, Scientific American,
January, 2009.
Cancer as an Evolutionary Phenomenon. Lutheran Theological
Seminary, Gettysburg, PA. 02/09/09.
Cancer as an Evolutionary Phenomenon. The Humanist Association
of Connecticut. Hamden, CT, 02/16/09.
Why Do Melanomas Get So Dark? Asian Society for Pigment Cell
Research, 3rd Meeting. Seoul, South Korea, 06/09.
Why Do Melanomas Get So Dark? Pan American Society Pigment
Cell Research, Memphis, TN, 09/04/2010
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2009-Keynote Lecture
2009-Keynote Lecture
2010-Invited Lecture
2010-Participant
2010-Keynote Lecture
2010-Lecture
2010-Keynote Lecture
2010-Lecture
2010-Faculty
2011-Lecture
2011-Lectures
2011-Lecture
2012-Lecture
2012-Lecture
2013-Lecture
“The Leukocyte-Cancer Cell Fusion Theory of Metastasis.”
Congress on Progenitor cells, Microenvironment, and Cell Fusion
in Cancer Progression. Stockholm, Sweden, 10/09.
“The role of bone marrow derived cells in the process of
metastasis”, Congress of the International Society of Oncology
and Biomarkers (ISOBM), Amsterdam, Netherland 9/09.
Cancer as an Evolutionary Phenomenon, Dept. Mol Cell Biology
Univ. Texas, Dallas, 04/22/10
Eureka Forum, Univ. Texas, Dallas, 04/22/10
Pigmentation Research: Yesterday, Today, and Tomorrow, ASPCR
4th Meeting, Guangzhou, China, 13/06/10
The Colors of Our Skin. Humanist Association of Connectitut,
Hamden, CT 9/20/10
Symposium on CD163 and Inflammation, Arhus University,
Sandbjerg Estate, Denmark, 8-11 Sept 2010
The Colors of Our Skin. Biology in the Afternoon Seminar Series,
Gettysburg College, Gettysburg PA, 9/2910
NCI Workshop on Cell Fusion and Cancer, Bethesda, 16/12/10
“Melanocyte Fusions: Normal and Malignant” World Congress
Dermatology/ASPCR, Seoul, S. Korea, 5/11
“Leucocyte-Cancer Fusion in Melanoma”; “Autophagy in Cancer”
IPCC 2011, Bordeaux, France 9/11.
“Cancer!”, The 13th Robert M. Young Memorial Lecture, Rhode
Island College, Providence, RI 11/16/11.
“Cell fusion and Cancer”. Van Andel Research Institute, Grand
Rapids, MI. 02/27/12
“A melanoma metastasis with a donor-patient hybrid genome
following bone marrow transplant.” Dermatology Seminar
Series, YSM, 4/11/12
“Key roles for sialyl(
-terminated glycans in
melanogenesis and melanosome transfer. Pan American
Society for Pigment Cell Research, Madison, WI. Sept.8-11, 2013
BIBLIOGRAPHY
Original Articles:
Pawelek J. Effects of thyroxin and low oxygen tension on chondrogenic expression in cell
culture. Devel Biol 19:52-72, 1969.
Pawelek J, Godchaux W, Grasso J, Skoultchi A, Eisenstadt J, and Lengyel P. Occurrence of
cysteinyl transfer ribonucleic acid with a blocked amino group in rabbit reticulocytes. Bioch
Biophys Acta 232:289-305, 1971.
Wong G and Pawelek J. Control of phenotypic expression of cultured melanoma cells by
melanocyte-stimulating hormones. Nature NB 241:213-215, 1973.
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Wong G, Pawelek J, Sansone M, and Morowitz J. Response of mouse melanoma cells to
melanocyte-stimulating hormone. Localization in the G-2 phase of the cell cycle. Nature
248:351-354, 1974.
Varga JM, DiPasquale A, Pawelek J, McGuire J, and Lerner A. Regulation of melanocytestimulating hormone (MSH) action at the receptor level: Discontinuous binding of MSH to
synchronized mouse melanoma cells during the cell cycle. Proc Nat Acad Sci USA 71:15901593, 1974.
Pawelek J, Sansone M, Morowitz J, Moellmann G, and Godawska E. Genetic control of
melanization: Isolation and analysis of amelanotic variants from cultured melanotic melanoma
cells. Proc Nat Acad Sci USA 71:1073-1077, 1974.
Pawelek J, Sansone M, Koch N, Christie G, Halaban R, Hendee J, Lerner A, and Varga J.
Melanoma cells resistant to inhibition of growth by melanocyte-stimulating hormone. Proc Nat
Acad Sci USA 72:951-956, 1975.
Wong G and Pawelek J. Melanocyte-stimulating hormone activates preexisting tyrosinase
molecules in mouse melanoma cells. Nature 255:644-646, 1975.
Pawelek J, Halaban R, and Christie G. Melanoma cells with a cyclic AMP growth requirement.
Nature 258:539-540, 1975.
Korner A and Pawelek J. Activation of melanoma tyrosinase by a cyclic AMP-dependent
protein kinase in a cell-free system. Nature 267:444-447, 1977.
Breakefield XO, Castiglione CM, Halaban R, Pawelek J, and Shiman R.
hydroxylase in melanoma cells. J Cell Physiol 94:265-274, 1978.
Phenylalanine
Dryja TP, Pawelek JM, and Albert DM. Demonstration of tyrosinase in adult porcine and bovine
uveal tracts. Invest Opthalmology, and Vis Sci 17:511-514, 1978.
*Pawelek J and Lerner AB. 5',6’-Dihydroxyindole is a melanin precursor exhibiting potent
cytotoxicity. Nature 276:627-628, 1978.
Pawelek JM. Evidence suggesting that a cyclic AMP-dependent protein kinase is a positive
regulator of proliferation in Cloudman S91 melanoma cells. J Cell Physiol 98:619-625, 1979.
Pawelek J. A Cyclic AMP requirement for proliferation of Cloudman S91 melanoma cells.
Pigment Cell 4:167-176, 1979.
Kahn R, Murray M, and Pawelek J. Inhibition of proliferation of Cloudman S91 melanoma cells
by insulin and characterization of some insulin resistant variants. J Cell Physiol 103:109-120,
1980.
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Korner A and Pawelek J. Dopachrome conversion: A possible regulatory point in melanin
biosynthesis. J Invest Derm 75:192-195, 1980.
Pawelek J, Korner A, Bergstrom A, and Bolognia J. New regulators of melanin biosynthesis and
the auto- destruction of melanoma cells. Nature 286:617-619, 1980.
Korner A, Murray M, Bergstrom A, and Pawelek J. New control points in melanin biosynthesis
and the auto destruction of melanoma cells. Pigment Cell 6:43-49, 1981.
Lande S, Pawelek J, Lerner AB, Emanuel JR. Assay of melanotropic peptides in an in vitro
mammalian system. J Invest Dermatol. 198;77:244-5.
Hearing VJ, Korner A, and Pawelek J. New regulators of melanogenesis are associated with
purified tyrosinase isozymes. J Invest Derm 79:16-18, 1982.
Korner A and Pawelek J. Mammalian tyrosinase catalyses three reactions in biosynthesis of
melanin. Science 217:1163-1165, 1982.
Pawelek J, Emanuel J, Kahn R, Murray M, and Fleischmann R. Interactions between insulin and
the cyclic AMP system of Cloudman S91 mouse melanoma cells. J Cell Biochem 21:289-297,
1983.
Murray M, Pawelek J, and Lamoreux ML. New regulatory factors for melanogenesis:
Developmental changes in neonatal mice of various genotypes. Dev Biol 100:120-126, 1983.
Pawelek J, Fleischmann R, McLane J, Guillette B, Emanuel J, Korner A, Bergstrom A, and
Murray M. Studies on growth and pigmentation of Cloudman S91 melanoma cells. Pigment
Cell 6:521-533, 1984.
Haring HU, White MF, Kahn CR, Kasuga M, Lauris V, Fleischmann R, Murray M, and Pawelek
J. Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma
line. J Cell Biol 99:900-908, 1984.
Fleischmann RD and Pawelek JM. Evidence that a 90,000 Dalton phosphoprotein, an associated
kinase, and a specific phosphatase are involved in the regulation of melanoma cell proliferation
by insulin. Proc Nat Acad Sci USA 82:1007-1011, 1985.
Pawelek JM. Studies on the Cloudman melanoma cell line as a model for the action of MSH.
Yale J Biol and Med 58:571-578, 1985.
Pawelek J and Murray M. Increase in melanin formation and promotion of cytotoxicity in
cultured melanoma cells caused by phosphorylated isomers of L-dopa. Cancer Research 46:492493, 1986.
Bolognia J and Pawelek J. L-dopa regulates proliferation of melanoma cells. J Invest Derm
87:420, 1986.
10
McLane J, Osber M, and Pawelek JM. Phosphorylated isomers of L-dopa stimulate MSH
Binding capacity and responsiveness to MSH in cultured melanoma cells. Bioch Biophys Res
Comm 145:719-725, 1987.
Agin PP, Sayre RM, and Pawelek JM. Phosphorylated mixed isomers of L-dopa increase
melanin content in skins Skh-2 pigmented hairless mice. Pigment Cell Res 1:137-142, 1987.
Slominski A and Pawelek J. MSH binding in Bomirski amelanotic hamster melanoma cells is
stimulated by L-tyrosine. Bioscience Reports 7:949-954, 1987.
Slominski A, Moellmann G, Kuklinska E, Bomirski A, and Pawelek J. Positive regulation of
melanin pigmentation by two key substrates of the melanogenic pathway: L-tyrosine and L-dopa.
J Cell Science 89:287-296, 1988.
McLane J and Pawelek JM. Receptors for -MSH in synchronized Cloudman melanoma cells
exhibit positive cooperativity in the late S and G2 phase of the cell cycle. Biochemistry,
27:3743-3747, 1988.
Bolognia J, Murray M, and Pawelek J. Evidence that UVB-induced melanogenesis is mediated
through the MSH receptor system. J Invest Dermatol 92:651-656, 1989.
Slominski A, Jastreboff P, and Pawelek J. L-tyrosine stimulates induction of tyrosinase activity
by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma
cells. Biosci Rep 9:579-586, 1989.
Pawelek JM. Is human melanogenesis stimulated by cyclic AMP? J Invest Dermatol 94:499500, 1990.
Pawelek JM. Dopachrome conversion factor functions as an isomerase. Bioch Biophys Res
Comm 166:1328-1333, 1990.
Orlow S, Chakraborty AK, and Pawelek J. Retinoic acid is a potent inhibitor of inducible
pigmentation in mouse and hamster melanoma cells. J. Invest. Derm. 94:461-464, 1990.
Orlow S, Hotchkiss S, and Pawelek J. Internal binding sites for MSH in wild type and variant
Cloudman melanoma cells. J Cell Phys 142:129-136, 1990.
Bolognia J, Murray-Gonzales M, and Pawelek J. Hairless pigmented guinea pigs: A new animal
model for studies of the pigmentary system. Pigment Cell Research 3:150-156, 1990.
Orlow S, Chakraborty AK, Boissy R, and Pawelek J. Inhibition of induced melanogenesis in
Cloudman melanoma cells by four phenotypic modifiers. Exp. Cell Res. 191:209-218, 1990.
Chakraborty AK, Orlow SJ, and Pawelek JM. Stimulation of melanocyte-stimulating hormone
receptors by retinoic acid. FEBS Lett. 276:205-208, 1990.
11
Birchall N, Orlow SJ, Kupper T, and Pawelek J. Ultraviolet light regulates IL-1 production, and
IL-1 regulates MSH binding in both mouse melanoma and human squamous carcinoma cells.
Bioch. Biophys. Res. Comm. 175:839-845, 1991.
Chakraborty AK, Orlow SJ, Bolognia J, and Pawelek J. Structural/functional relationships
between internal and external MSH receptors: Modulation of expression in Cloudman melanoma
cells by UVB radiation. J. Cell. Physiol., 147:1-6, 1991.
Pawelek J. After Dopachrome? Pigment Cell Res 4:53-62, 1991.
Chakraborty AK, Orlow SJ, and Pawelek JM. Evidence that dopachrome tautomerase is a
ferrous iron-binding glycoprotein. FEBS Lett, 302:126-128, 1992.
Orlow SJ, Chakraborty AK, and Pawelek JM. Membrane glycoproteins common to vesicles and
melanosomes in mouse melanoma cells. Pigment Cell Res Suppl 2: 162-170, 1992.
Pawelek JM, Orlow SJ, and Osber MP. Synthesis and characterization of melanins from
dihydroxyindole-2-carboxylic acid and dihydroxyindole. Pigment Cell Res 5:113-121, 1992.
Slominski A, McNeely T, and Pawelek J. Defect of insulin receptor in insulin-resistant variants
of Cloudman S91 mouse melanoma cells. Melanoma Res 2:115-122, 1992.
Pawelek JM, Chakraborty AK, Osber MP, Orlow SJ, Min KK, Rosenzweig KE, and Bolognia,
JL. Molecular cascades in UV-induced melanogenesis: A central role for melanotropins?
Pigment Cell Res 5:348-356, 1992.
Chakraborty AK and Pawelek J. Upregulation of MSH receptor by MSH in Cloudman melanoma
cells. Biochem Biophys Res Comm 188:1325-1331, 1992.
Chakraborty AK and Pawelek J. MSH receptors in immortalized human epidermal keratinocytes:
A potential mechanism for coordinate regulation of the epidermal melanin unit. J Cell Physiol
157:344-350, 1993.
Pawelek JM. Melanoma as a macrophage/melanocyte hybrid and the symbiotic nature of
eukaryotic cells. Melanoma Res 3:75-76, 1993.
Orlow, SJ, Zhou B, Chakraborty AK, Drucker M, Pifko-Hirst S, and Pawelek JM. High
molecular weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a
melanogenic complex. J. Invest. Derm. 103:196-201, 1994.
Chakraborty AK, Bolognia JL, Orlow SJ, Sodi SA, and Pawelek, JM. The biochemistry of skin
pigmentation and its relation to melanoma. J. Indian Chem. Soc. 71:489-494, 1994.
Bolognia JL, Sodi SA, Chakraborty AK, Fargnoli MC, and Pawelek JM. Effects of ultraviolet
irradiation on the cell cycle. Pigment Cell Research 7:320-325, 1994.
12
Bolognia JL, Sodi SA, Osber MP, and Pawelek J. Enhancement of the depigmentary effects of
hydroquinone by buthionine sulfoximine. Br. J. Dermatol. 133:349-357, 1995.
Chakraborty A, Slominski A, Ermak G, Hwang J, and Pawelek J. Ultraviolet B and melanocytestimulating hormone (MSH) stimulate mRNA
proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes.
J Invest Dermatol 105:655-659, 1995.
Chakraborty AK, Platt JT, Kim KK, Kwon BS, Bennett DC, and Pawelek JM. Superoxidedependent polymerization of DHICA to melanin by the si (silver) locus protein, PMEL-17. Eur
J Biochem 236:180-188, 1996.
Chakraborty AK, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek JM, and Ichihashi M.
Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes
and keratinocytes in culture: regulation by ultraviolet B. BBA, 1313:130-138, 1996.
Slominski A, Baker J, Ermak G, Chakraborty A, and Pawelek J. Ultraviolet B stimulates
production of corticotropin releasing factor (CRF) by human melanocytes. FEBS Letters
399:175-176, 1996.
Pawelek J, Low KB, and Bermudes D. Tumor-targeted Salmonella as a novel anti-cancer vector.
Cancer Res 57:4537-4544, 1997.
Rachkovsky MS, Sodi S, Chakraborty A, Avissar Y, Bolognia J, Madison J, Bermudes D, and
Pawelek J. Enhanced metastatic potential of melanoma x macrophage fusion hybrids. Clin Exp
Metastasis 16: 299-312, 1998.
Sodi S.A., Chakraborty A.K., Platt J.T., Kolesnikova, N., Rosemblat, S., Keh-Yen, A.,
Bolognia, J.L., Rachkovsky, M.L., Orlow, S.J., and Pawelek, J.M. Melanoma x macrophage
fusion hybrids acquire increased melanogenesis and metastatic potential: Altered Nglycosylation as an underlying mechanism. Pigment Cell Res. 11: 299-309, 1998.
Funasaka Y; Chakrabortry AK; Hayashi Y; Komoto M; Ohashi A; Nagahama M; Inoue T;
Pawelek J; and Ichihashi M. Modulation of melanocyte stimulating hormone receptor
expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B,
interleukin-1a, interleukin-1b, endothelin and tumor necrosis factor-alpha. British J.
Dermatology, 139, 216-224, 1998.
Pawelek, J.M. MelaSynTM: A new self-tanner with sun protective qualities. DCI 163: 28-33,
Oct. 1998.
Low, K.B. Ittensohn, M., Le T., Platt, J., Sodi, S., Amoss, M., Ash, O., Carmichael, E.,
Chakraborty, A., Fischer, J., Lin, S.L., Luo, X., Miller, S.I., Zheng, L-m., King, I., Pawelek,
induction retain tumor-targeting in vivo. Nature Biotechnology 17: 37-41, 1999.
13
Rachkovsky, M. and Pawelek, J. Acquired melanocyte stimulating hormone-inducible
chemotaxis following macrophage fusion with Cloudman S91 melanoma cells. Cell Growth and
Differentiation 10: 515-524, 1999.
Chakraborty, A.K., Funasaka, Y., Ichihashi, M., Sodi, S., Bhattacharya, M., and Pawelek, J.
Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in
macrophage x melanoma fushion hybrids exhibiting increased melanogenic and metastatic
potential. Pig. Cell Res. 12: 355-366, 1999.
Chakraborty AK, Funasaka Y, Pawelek JM, Nagahama M, Ito A, Ichihashi M. Enhanced
expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during
differentiation: evidence for increased expression of POMC peptides near suprabasal layer of
epidermis. J Invest Dermatol. 1999;112:853-60.
Pawelek, J. M., Chakraborty, A. K., Rachkovsky, M. L., Orlow, S. J., Bolognia, J. L., and Sodi,
S. A. Altered N-glycosylation in macrophage x melanoma fusion hybrids. Cell. Mol. Biol., 45:
1011-1027, 2000.
Chakraborty, A., Sodi, S., Rachkovsky, M., Kolesnikova, N., Platt, J., Bolognia, J. and Pawelek,
J. A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids. Cancer
Research 60: 2512-2519, 2000.
Platt, J., Sodi, S., Kelley, M., Rockwell, S., Bermudes, D., Low, K.B., and Pawelek, J. Antitumor
effects of genetically engineered Salmonella in combination with radiation. Eur. J. Cancer 36:
2397-2402, 2000.
Clairmont, C., Lee, K.C., Pike, J., Ittensohn, M., Low, K.B., Pawelek, J., Bermudes, D., Brecher,
S.M., Margitich, D., Turnier, J., Li, Z., Luo, X., King, I., and Zheng, L.M. Biodistribution and
genetic stability of the novel antitumor agent VNP20009, a genetically modified strain of
Salmonella typhimurium. J. Infect. Diseases 181: 1996-2002, 2000.
Araki, K., Horikawa, T., Chakraborty, A.K., Nakagawa, K., Itoh, H., Oka, M., Funasaka, Y.,
Pawelek, J., Ichihashi, M. Small GTPase RAB3A is associated with melanosomes in melanoma
cells. Pigment Cell Res 13(5): 332-336, 2000.
Chakraborty, A,K., Pawelek, J.M, Ikeda, Y., Miyoshi, E., Kolesnikova, N., Funasaka, Y.,
Ichihashi, M., and Tanaguchi, N. Macrophage fusion up-regulates N-acetylglucosaminyltransferase V, 
melanoma cells. Cell Growth and Differentiation 12: 623-630, 2001.
Chakraborty AK, de Freitas Sousa J, Espreafico EM, Pawelek JM. Human monocyte x mouse
melanoma fusion hybrids express human gene. Gene 275:103-6, 2001.
Pawelek JM, Sodi S, Chakraborty AK, Platt JT, Miller S, Holden DW, Hensel M, Low KB.
Salmonella pathogenicity island-2 and anticancer activity in mice. Cancer Gene Ther.10: 813-
14
818, 2002.
Chakraborty, A.K. and Pawelek, J.M. GnT-V, macrophages, and cancer metastasis: A common
link. Clin. Exp. Metastasis 20: 365-373, 2003.
Handerson, T., and Pawelek, J. 1,6-branched oligosaccharides and coarse vesicles: A common
and pervasive phenotype in melanoma and other human cancers. Cancer Res. 63: 5363-5369,
2003.
Pawelek, J., Low, K.B., and Bermudes, D. Bacteria as tumour-targeting vectors. Lancet Oncol. 4
(9): 548-556, 2003.
Chakraborty, A.K., Kolesnikova, N., de Freitas Sousa, J., Espreafico, E.M., Chagas Peronni, K.,
and Pawelek, J. Expression of c-met proto-oncogene in metastatic macrophage x melanoma
fusion hybrids: Implication of its possible role in MSH-induced motility. Oncol. Res. 14: 163174, 2003.
Rupani, R., Handerson, T., and Pawelek, J. Co-localization of 1,6-branched oligosaccharides
and coarse melanin in macrophage-melanoma fusion hybrids and human melanoma cells in vitro.
Pigment Cell Res. 17: 281-288, 2004.
Chakraborty A, Lazova R, Davies S, Bäckvall H, Ponten F, Brash D, Pawelek J. Donor DNA in
a renal cell carcinoma metastasis from a bone marrow transplant recipient. Bone Marrow
Transplant. 2004, 34:183-6.

Handerson, T., Camp, R., Harigopal, M., Rimm, D., and Pawelek, J. 
-Branched
oligosaccharides are associated with metastasis and predict poor outcome in breast carcinoma.
Clin. Can. Res. 11: 2969-2973, 2005.
Yilmaz, Y., Lazova, R., Qumsiyeh, M., Cooper, D., and Pawelek, J. Donor Y chromosome in
renal carcinoma cells of a female BMT recipient. Bone Marrow Transplant 35:1021-1024, 2005.
Siddiqui SF, Pawelek J, Handerson T, Lin CY, Dickson RB, Rimm DL, Camp RL. Coexpression
of beta1,6-N-acetylglucosaminyltransferase V glycoprotein substrates defines aggressive breast
cancers with poor outcome. Cancer Epidemiol Biomarkers Prev. 14:2517-2523, 2005.
Pawelek, J. Tumor cell fusion as a source of myeloid traits in cancer. The Lancet Onclogy 6:
988-993, 2005. (accompanying commentary: Friedl P. Cell fusion: new mechanisms of plasticity
in cancer? Lancet Oncol. 2005;12:916-918.)
Chakraborty AK, de Frietas Sousa J, Chakraborty D, Funasaka Y, Bhattacharya M, Chatterjee A,
Pawelek J. GnT-V expression and metastatic phenotypes in macrophage-melanoma fusion
hybrids is down-regulated by 5-Aza-dC: Evidence for methylation sensitive, extragenic
regulation of GnT-V transcription. Gene. 2006 Gene. 374:166-73.
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Valencia JC, Hoashi T, Pawelek JM, Solano F, Hearing VJ. Pmel17: controversial indeed but
critical to melanocyte function. Pigment Cell Res. 2006;19:250-2; author reply 253-7.
Handerson T, Berger A, Harigopol M, Rimm D, Chikako N, Ueda M, Miyoshi E, Taniguchi N,
Pawelek J. Melanophages reside in hypermelanotic, aberrantly glycosylated tumor areas and
predict improved outcome in primary CMM. J. Cutaneous Pathol, 34: 667-738, 2007.
Chakraborty AK, Pawelek, JM. 1,6-branched oligosaccharides regulate melanin content and
motility in macrophage-melanoma fusion hybrids. Melanoma Res, 2007 17: 9-16.
Pawelek J. Viewing malignant melanoma cells as macrophage-tumor hybrids. Cell Adhesion and
Migration 2007; 1:2-6.
Pawelek JM, Chakraborty AK. Fusion of tumour cells with bone marrow-derived cells: a
unifying explanation for metastasis. Nature Reviews Cancer 8: 377-386, 2008.
Pawelek JM, Chakraborty AK. The cancer cell--leukocyte fusion theory of metastasis. Adv
Cancer Res. 2008;101:397-444.
Lazova R, Pawelek J. Why do melanomas get so dark? Exptl Dermatol, 2009;18:934-938
Chakraborty AK, Funasaka Y, Ichihashi M, Pawelek JM. Upregulation of alpha and beta integrin
subunits in metastatic macrophage-melanoma fusion hybrids. Melanoma Res 2009, 19:343-349.
Lazova R, Klump V, Pawelek J. Autophagy in cutaneous malignant melanoma. J. Cutan Pathol,
2010;37:256-268.
Lazova R, Chakraborty A, Pawelek JM. Leukocyte-Cancer Cell Fusion: Initiator of the Warburg
Effect in Malignancy? Adv Exp Med Biol. 2011;714:151-172.
Lazova R, Chakraborty AK and Pawelek JM. Cancer cell fusion with myeloid cells:
Implications for energy metabolism in malignant hybrids. Cell fusions: Regulation and
control. L.-I. Larsson (ed.), Cell Fusions, DOI 10.1007/978-90-481-9772-9_16, 351.
Springer Science+Business Media B.V. 2011
Lazova R, Camp RL, Klump V, Siddiqui S, Amaravadi RK, Pawelek JM. Punctate LC3B
expression is a common feature of solid tumors and associated with proliferation, metastasis and
poor outcome. Clin Cancer Res. 2012;18:370-9.
Slominski A, Zmijewski MA, Pawelek J. L-tyrosine and L-dihydroxyphenylalanine as hormonelike regulators of melanocyte functions. Pigment Cell Melanoma Res 2012, 25: 14-27.
Klionsky et al. Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 2012, 8:4, 1–100.
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Low, K. B., Murray, S. R., Pawelek, J. and Bermudes, D. Isolation and Analysis
of Suppressor Mutations in Tumor-Targeted msbB Salmonella, In R. Hoffman (ed), Bacterial
Therapy of Cancer: Methods and Protocols, Humana Press, 2014.
Rossitza Lazova, Greggory S. LaBerge, Eric Duvall, Nicole Spoelstra, Vincent Klump,
Mario Sznol, Dennis Cooper, Richard A. Spritz, Joseph T. Chang, John M. Pawelek (2013). A
Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow
Transplantation: First Evidence for Fusion in Human Cancer. PLoS ONE 8(6): e66731.
doi:10.1371/journal.pone.0066731.
Yale press release http://news.yale.edu/2013/06/26/how-cancer-spreads-metastatictumor-hybrid-cancer-cell-and-white-blood-cell.
Univ Colorado press release www.coloradocancerblogs.org.
Gettysburg College press release:
http://www.gettysburg.edu/news_events/press_release_detail.dot?id=3434647
Reviews and Book Chapters:
Pawelek J, Wong G, Sansone M, and Morowitz J. Molecular controls in mammalian
pigmentation. Yale J Biol and Med 46:430-443, 1973.
Pawelek J. Factors regulating growth and melanization in mammalian melanoma cells. J Invest
Derm (Review Article), 66:201-209, 1976.
Pawelek JM. Melanoma cells in "Cell Culture" (A volume of Methods in Enzymology) Kokoby
WB, and Pastan I. eds. Academic Press, Inc., New York, Vol. LVII, pp. 564-570, 1978.
Lerner AB, Moellmann G, Varga JM, Halaban R, and Pawelek J. "Action of melanocytestimulating hormone on pigment cells" in Hormones and Cell Culture, Cold Spring Harbor
Conferences on Cell Proliferation, Vol. 6, pp. 187-197, 1979.
Pawelek JM and Korner A. The Biosynthesis of Melanin in Mammals. American Scientist,
70:136-145, 1982.
Pawelek JM, Murray M, and Fleischmann R. "A genetic approach to studies of insulin action" in
Growth of Cells in Hormonally Defined Media, Cold Spring Harbor Conferences on Cell
Proliferation, 9:911-919, 1982.
Pawelek J. "Regulation of Pigmentation and Proliferation of Cultured Melanocytes" in Cell
Culture Methods in Molecular and Cellular Biology, Vol. 4, (DW Barnes, DA Sirbaski, GH Sato,
eds.), Alan R. Liss, Inc., NY, pp 57-66, 1984.
Bolognia JL, Ferreira JA, Lerner AB, and Pawelek J. "Disorders of Pigmentation" in Basic
Science of Cutaneous Surgery, ed. R. Rudolph, CV Mosby Co., St. Louis, pp 282-296, 1986.
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Pawelek J, Bolognia J, McLane J, Murray M, Osber M, and Slominski A. A possible role for
melanin precursors in regulating both pigmentation and proliferation of melanocytes in "Progress
in Clinical Biological Research" 256:143-154, 1988, Alan R. Liss, Inc., New York.
Pawelek J, McLane J, and Osber M. "Melanogenesis" in The Melanotropic Peptides Vol. III M.
Hadley, ed., CRC Press, Boca Raton, FL, pp. 47-58, 1988.
Bolognia JL and Pawelek J. Biology of Hypopigmentation. J Amer Acad Derm 19:217-258,
1988. (Continuing Medical Education Article)
Pawelek J, Bolognia JL, Chakraborty AK, Murray-Gonzalez M, and Orlow SJ. "Biology of
melanoma" in: Cutaneous melanoma: Biology and Management. Cascinelli N, Santinami M
and Veronesi U, eds. Masson Co., Milano, pp 3-16, 1990.
Pawelek JM and Osber MP. "Synthesis of 125I-Labelled ß-Melanotropin and Assay of
Melanotropin Receptors" in Methods in Neurosciences Vol. 5, ed. P.M. Conn. Academic Press,
Inc., San Diego, pp 354-361, 1991.
Pawelek JM, Chakraborty AK, Osber MP, and Bolognia J. Ultraviolet light and pigmentation of
the skin. Cosmetics and Toiletries, 107:1-7, 1992.
Pawelek JM. POMC in skin: New possibilities for regulation of skin physiology. Lab Clin
Invest (Editorial), J. Lab. Clin. Med., 122: 627-628, 1993.
Pawelek J, Platt J, Pugliese PT, and Chakraborty AK. Enzymatic and non-enzymatic synthesis
of melanins. In Melanin: Its role in Human Photoprotection. Valdenmar Publishing Co.,
Overland Park, KS. pp 109-115, 1995.
Pawelek J and Chakraborty AK. "The Enzymology of Melanogenesis" in The Pigmentary
System and Its Disorders. (eds. Nordland JJ, Boissy RE, Hearing VJ, King RA, and Ortonne JP)
Oxford University Press, 391-400, 1998.
Slominski A and Pawelek J. Animals under the sun: effects of UV radiation on mammalian skin.
Clinics in Dermatol. 16: 503-515, 1998.
Chakraborty AK, Funasaka Y, Slominski A, Bolognia J, Sodi S, Ichihashi M, Pawelek JM. UV
light and MSH receptors. Ann N Y Acad Sci. 1999;885:100-16.
Bermudes, D., Low, B., and Pawelek, J. Tumor-targeted Salmonella: Highly selective delivery
vectors. In Cancer Gene Therapy: Past achievements and future challenges, N. Habib (ed),
Plenum Press, 75-63, 1999.
Bermudes, D., Low, B., and Pawelek, J. Tumor-targeted Salmonella: Strain development and
expression of the HSV TK effector gene. In: Gene Therapy: Methods and Protocols, W. Walther
and U. Stein eds. 2000. Humana Press, Totowa, NJ, Vol 35: 419-436.
18
Bermudes, D., Low, K.B., Pawelek, J., Sznol, M., Belcourt, M., Zheng, L-m, and King, I.
Tumor-specific Salmonella-based cancer therapy. Stephen E. Harding (ed) Biotechnology and
Genetic Engineering Rev. 18: 219-233, 2001.
Pawelek, J.M. Tumor Cell Hybridization and Metastasis Revisited. Melanoma Res. 10: 507-514,
2000.
Pawelek, J.M. Review - Innovative Technology: Approaches to Increasing Skin Melanin with
MSH Analogs and Synthetic Melanins. Pigment Cell Res. 14: 155-160, 2001.
Low, K.B., Ittenshohn, M., Luo, X., Zheng, L.M., King, I., Pawelek, J.M., and Bermudes, D.
Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumortargeting Salmonella for parenteral administration in humans. Methods Mol Med. 90: 47-60,
2004.
Pawelek J, Chakraborty A, Lazova R, Yilmaz Y, Cooper D, Brash D, Handerson T. Co-Opting
Macrophage Traits in Cancer Progression: A Consequence of Tumor Cell Fusion? Contrib
Microbiol. 2006;13:138-155.
Pawelek JM. Cancer cell fusion with migratory bone marrow-derived cells as an explanation for
metastasis: new therapeutic paradigms. Future Oncol. (2008) 4:449-52.
Pawelek, J.M. Does Fusion Therapy Have a Role in Cancer? Genetic Engineering and
Biotechnology News. vol 29 (No. 2): 46, Jan 15, 2009.
19