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KAMIYA BIOMEDICAL COMPANY Rev. 030207 PRODUCT DATA SHEET Product: Anti-ECSIT (CT) pAb Cat. No.: PC-477 (100 µg) Applications: Synonyms: Western blot: Use at 0.5 to 1 µg/mL. Immunohistochemistry: Use at about 2 µg/mL for mouse heart cells. The optimal dilution for a specific application should be determined by the researcher. Evolutionarily conserved signaling intermediate in Toll pathway Description: Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways. Western blot analysis of ECSIT in human heart cell lysates with ECSIT (CT) pAb at (A) 0.5, (B) 1, and (C) 2 µg/mL. Immunohistochemical staining of ECSIT in mouse heart cells with ECSIT (CT) pAb at 2 µg/mL. Host: Rabbit Species Reactivity: Human, and mouse. Limitations: Immunogen: For in vitro research use only. Not for use in diagnostics or in humans. Raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT (GenBank accession no. NP_057665). Warranty: No warranties, expressed or implied, are made regarding the use of this product. KAMIYA BIOMEDICAL COMPANY is not liable for any damage, personal injury, or economic loss caused by this product. Format: 100 µg at 1 mg/mL of polyclonal IgG in PBS containing 0.02% sodium azide. Ion-exchange chromatography purified. Storage: Store at 4°C. KAMIYA BIOMEDICAL COMPANY, Seattle, WA www.k-assay.com USA Tel: (206) 575-8068 • Fax: (206) 575-8094 [email protected]