Full Text - The Journal of Immunology
... Leptin is mainly secreted by the adipose tissue, which is also present within both primary and secondary lymphoid organs and has a significant metabolic and immunomodulatory role (9, 10). Leptin’s three-dimensional structure is similar to that of a cytokine consisting of a four ␣ helix bundle motif ...
... Leptin is mainly secreted by the adipose tissue, which is also present within both primary and secondary lymphoid organs and has a significant metabolic and immunomodulatory role (9, 10). Leptin’s three-dimensional structure is similar to that of a cytokine consisting of a four ␣ helix bundle motif ...
Role of extracellular ATP in immunity and intestinal defence
... and pyrimidines. Following cellular uptake, methotrexate is polyglutamated inside cells. The polyglutamated form of methotrexate then inhibits an important enzyme involved in purine biosynthesis: 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase. Inhibition of AICAR transformylase ...
... and pyrimidines. Following cellular uptake, methotrexate is polyglutamated inside cells. The polyglutamated form of methotrexate then inhibits an important enzyme involved in purine biosynthesis: 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase. Inhibition of AICAR transformylase ...
Insoluble and soluble immune complexes activate neutrophils by
... Background: Rheumatoid synovial fluid contains both soluble and insoluble immune complexes that can activate infiltrating immune cells such as neutrophils. Objectives: To determine if these different complexes activate neutrophils through similar or different receptor signalling pathways. In particu ...
... Background: Rheumatoid synovial fluid contains both soluble and insoluble immune complexes that can activate infiltrating immune cells such as neutrophils. Objectives: To determine if these different complexes activate neutrophils through similar or different receptor signalling pathways. In particu ...
Outlines
... This first indication for the expression of the Y1 receptor on immune cells was further substantiated by De la Fuente et al (1993) who demonstrated binding sites for radiolabeled NPY on peritoneal murine macrophages. ...
... This first indication for the expression of the Y1 receptor on immune cells was further substantiated by De la Fuente et al (1993) who demonstrated binding sites for radiolabeled NPY on peritoneal murine macrophages. ...
Differential requirement for A2a and A3 adenosine
... From www.bloodjournal.org by guest on June 17, 2017. For personal use only. BLOOD, 15 DECEMBER 2003 䡠 VOLUME 102, NUMBER 13 ...
... From www.bloodjournal.org by guest on June 17, 2017. For personal use only. BLOOD, 15 DECEMBER 2003 䡠 VOLUME 102, NUMBER 13 ...
Concepts of citrate production and secretion by prostate 1. Metabolic
... Consequently, prostatic fluid citrate concentration is 240-1,300 times greater than the plasma Concentration. Although prostatic fluid citrate values vary considerably, this relationship exists in all animals containing citrate-producing prostate glands. The citrate concentration of human prostatic ...
... Consequently, prostatic fluid citrate concentration is 240-1,300 times greater than the plasma Concentration. Although prostatic fluid citrate values vary considerably, this relationship exists in all animals containing citrate-producing prostate glands. The citrate concentration of human prostatic ...
Platelets: versatile effector cells in hemostasis, inflammation, and the
... bacterial pathogens [4, 55, 60]. Human platelets have been reported to engulf bacteria and other microbes, potentially via the open cannalicular system [22, 55, 60, 63]. In parallel, many factors released from granules of activated platelets, or generated by active synthesis, have major antibacteria ...
... bacterial pathogens [4, 55, 60]. Human platelets have been reported to engulf bacteria and other microbes, potentially via the open cannalicular system [22, 55, 60, 63]. In parallel, many factors released from granules of activated platelets, or generated by active synthesis, have major antibacteria ...
The Origins, Specificity, and Potential Biological
... in the bone marrow (central tolerance) or in the periphery (peripheral tolerance). B cells recognize antigen through their B-cell antigen receptors (BCR), which can subsequently be secreted as antibodies into the serum as a part of the humoral immune response. When a breakdown in either B-cell centr ...
... in the bone marrow (central tolerance) or in the periphery (peripheral tolerance). B cells recognize antigen through their B-cell antigen receptors (BCR), which can subsequently be secreted as antibodies into the serum as a part of the humoral immune response. When a breakdown in either B-cell centr ...
Adenosine Receptors as Targets for Therapeutic Intervention
... A1 antagonists protect against decline in renal function seen with diuretic therapy, while augmenting the diuresis! Increased adenosine sensitivity (with increased vasoconstriction) may be important in the pathogenesis of contrast-induced nephrotoxicity.52 Blood: Platelets effects Effects have been ...
... A1 antagonists protect against decline in renal function seen with diuretic therapy, while augmenting the diuresis! Increased adenosine sensitivity (with increased vasoconstriction) may be important in the pathogenesis of contrast-induced nephrotoxicity.52 Blood: Platelets effects Effects have been ...
Linköping University Post Print Induction of apoptosis in human neutrophils by
... PMNs that infiltrate the tissue infected with Mtb participate not only in removal of the bacteria [6], but also in the orchestration of inflammation through release of cytokines and chemokines [7]. PMNs have a short lifespan of 24-72 hours and apoptotic cells are usually cleared by macrophages, medi ...
... PMNs that infiltrate the tissue infected with Mtb participate not only in removal of the bacteria [6], but also in the orchestration of inflammation through release of cytokines and chemokines [7]. PMNs have a short lifespan of 24-72 hours and apoptotic cells are usually cleared by macrophages, medi ...
1 - Tistory
... Perhaps aspects of the way in which Prof Boussiotis’s report was prepared could be criticised but even if those points are well founded, none of them persuaded me that I should discount the evidence of the professor. The way in which Prof Rudd answered the questions put in cross-examination involved ...
... Perhaps aspects of the way in which Prof Boussiotis’s report was prepared could be criticised but even if those points are well founded, none of them persuaded me that I should discount the evidence of the professor. The way in which Prof Rudd answered the questions put in cross-examination involved ...
NIH Public Access
... (between endothelial cells, as shown in Figure 1) or a transcellular (through endothelial cells) route. Most transmigration occurs via the paracellular route, although the transcellular route is favored when endothelial expression of intracellular adhesion molecule (ICAM)-1 is high (38). Paracellula ...
... (between endothelial cells, as shown in Figure 1) or a transcellular (through endothelial cells) route. Most transmigration occurs via the paracellular route, although the transcellular route is favored when endothelial expression of intracellular adhesion molecule (ICAM)-1 is high (38). Paracellula ...
The Role of Antibodies in Mouse Models of Rheumatoid Arthritis
... three known FcR. All three types are found on macrophages, neutrophils, eosinophils, and dendritic cells, with further differences in expression as follows. FcgRI is of relatively high affinity and is also found on monocytes. FcgRII and FcgRIII are of lower affinity and therefore bind better to larg ...
... three known FcR. All three types are found on macrophages, neutrophils, eosinophils, and dendritic cells, with further differences in expression as follows. FcgRI is of relatively high affinity and is also found on monocytes. FcgRII and FcgRIII are of lower affinity and therefore bind better to larg ...
Bile acids activate ryanodine receptors in pancreatic acinar cells via
... [5]. In permeabilized cell assay, bile acid retained its effect when IP3 R or RyR were blocked, but failed when both IP3 R and RyRs were inhibited [12]. Moreover, both dantrolene and ryanodine converted bile acid-induced sustained intracellular [Ca2+ ] elevations to physiological Ca2+ oscillations i ...
... [5]. In permeabilized cell assay, bile acid retained its effect when IP3 R or RyR were blocked, but failed when both IP3 R and RyRs were inhibited [12]. Moreover, both dantrolene and ryanodine converted bile acid-induced sustained intracellular [Ca2+ ] elevations to physiological Ca2+ oscillations i ...
fulltext
... antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. Naïve mice have very low amounts of specific an ...
... antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. Naïve mice have very low amounts of specific an ...
Aryl Hydrocarbon Receptor Control of Adaptive Immunity
... the transcription factor FoxP3, which is needed for their differentiation and function (Sakaguchi et al., 2010). FoxP3+ Tregs play a central role in the control of immune reactivity to self and non-self antigens, as shown by the inflammatory conditions associated with mutant FoxP3 in humans (Sakaguc ...
... the transcription factor FoxP3, which is needed for their differentiation and function (Sakaguchi et al., 2010). FoxP3+ Tregs play a central role in the control of immune reactivity to self and non-self antigens, as shown by the inflammatory conditions associated with mutant FoxP3 in humans (Sakaguc ...
Pathogen-Induced Apoptotic Neutrophils Express Heat
... apoptosis in neutrophils represents a pathogenic strategy for microbes to eliminate these key immune cells and use them as “Trojan horses” to enter M. However, in the cited studies, neutrophil apoptosis was induced by age or irradiation; thus, the results may not apply to the very early phase of in ...
... apoptosis in neutrophils represents a pathogenic strategy for microbes to eliminate these key immune cells and use them as “Trojan horses” to enter M. However, in the cited studies, neutrophil apoptosis was induced by age or irradiation; thus, the results may not apply to the very early phase of in ...
Recent developments in basophil research
... dependent interleukin (IL) -4 and IL-13 secretion by these cells was discovered (Figure 1) [5-8]. More ...
... dependent interleukin (IL) -4 and IL-13 secretion by these cells was discovered (Figure 1) [5-8]. More ...
Fragile Skin: Benefit of Cosmeceuticals based on Rhealba® Oat
... Rhealba® Oat Plantlets extract and its purified active substances were therefore studied in vitro in several cell models mimicking the different pathways of activation of inflammation[31]. The results suggest that Rhealba® Oat Plantlets extract exerts interesting immunomodulatory activity. In fact, ...
... Rhealba® Oat Plantlets extract and its purified active substances were therefore studied in vitro in several cell models mimicking the different pathways of activation of inflammation[31]. The results suggest that Rhealba® Oat Plantlets extract exerts interesting immunomodulatory activity. In fact, ...
Journal of Otology & Rhinology
... It is well known that antioxidative enzymes (AOEs), such as catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), superoxide dismutase (SOD) and glutathione S-transferase (GST), are of great importance in the mucosal defense against reactive oxygen species[1]. Previous studies re ...
... It is well known that antioxidative enzymes (AOEs), such as catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), superoxide dismutase (SOD) and glutathione S-transferase (GST), are of great importance in the mucosal defense against reactive oxygen species[1]. Previous studies re ...
Studies on the antimicrobial defence of human hair follicle epithelium
... jedermann benutzt werden dürfen. This document is protected by copyright law. No part of this document may be reproduced in any form by any means without prior written authorization of the publisher. ...
... jedermann benutzt werden dürfen. This document is protected by copyright law. No part of this document may be reproduced in any form by any means without prior written authorization of the publisher. ...
prolongation of allograft survival in ccr7
... 12.3ⴞ0.9 days). This was accompanied by a delay in the cellular infiltration of allografts. T-cell accumulation and expansion in the draining lymph nodes in CCR7ⴚ/ⴚ recipients was severely impaired. Splenectomy had only a moderate prolongation effect on allograft survival in CCR7ⴚ/ⴚ mice. Conclusion ...
... 12.3ⴞ0.9 days). This was accompanied by a delay in the cellular infiltration of allografts. T-cell accumulation and expansion in the draining lymph nodes in CCR7ⴚ/ⴚ recipients was severely impaired. Splenectomy had only a moderate prolongation effect on allograft survival in CCR7ⴚ/ⴚ mice. Conclusion ...
View PDF - Cardiovascular Research
... eNOS Thr495 phosphorylation, induced RhoA expression, and decreased NOdependent relaxation responses, all of which were prevented by either an IL-17 neutralizing antibody or inhibition of Rho-kinase. In mice, IL-17 treatment for 1 week significantly increased systolic blood pressure and this was ass ...
... eNOS Thr495 phosphorylation, induced RhoA expression, and decreased NOdependent relaxation responses, all of which were prevented by either an IL-17 neutralizing antibody or inhibition of Rho-kinase. In mice, IL-17 treatment for 1 week significantly increased systolic blood pressure and this was ass ...
Development of an Antigen-independent Affinity Assay to Study the
... FcγRIII. FcγRI has high affinity for IgG and is the only receptor capable of binding IgG in monomeric form. The other receptors have low to intermediate affinity for IgG and can only bind immune complexes. The receptors vary in IgG subclass specificity and also differ in the cellular response they g ...
... FcγRIII. FcγRI has high affinity for IgG and is the only receptor capable of binding IgG in monomeric form. The other receptors have low to intermediate affinity for IgG and can only bind immune complexes. The receptors vary in IgG subclass specificity and also differ in the cellular response they g ...
The Immune-Pineal Axis: the Role of Pineal and Extra
... relaxation of the rat aorta, induced by LPS, was also inhibited by melatonin. In this context, the melatonin effect was due to the inhibition of the nuclear factor kappa B (NFKB) pathway and was not blocked by luzindole. The concentration of melatonin required for the inhibition of the LPS effect is ...
... relaxation of the rat aorta, induced by LPS, was also inhibited by melatonin. In this context, the melatonin effect was due to the inhibition of the nuclear factor kappa B (NFKB) pathway and was not blocked by luzindole. The concentration of melatonin required for the inhibition of the LPS effect is ...
12-Hydroxyeicosatetraenoic acid
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a Hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z Cis–trans isomerism configuration (Z=cis, E=trans) in its four double bonds. It was first found as a product of arachidonic acid metabolism made by human and bovine platelets. However, the term 12-HETE is ambiquous in that it has been used to indicate not only the initially detected ""S"" stereoisomer, 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HETE or 12S-HETE), made by platelets, but also the later detected R stereoisomer, 12(R)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(R)-HETE or 12R-HETE) made by other tissues. The two isomers, either directly or after being further metabolized, have been suggested to be involved in a variety of human physiological and pathological reactions. Unlike hormones which are secreted by cells, travel in the circulation to alter the behavior of distant cells, and thereby act as Endocrine signalling agents, these arachidonic acid metabolites act locally as Autocrine signalling agents to regulate the behavior of their cells of origin or as Paracrine signalling agents to regulate the function of nearby cells. In these roles, they may amplify or dampen, expand or contract cellular and tissue responses to disturbances.