Neutrophils in tuberculosis: heterogeneity shapes the way?
... Macrophages phagocyte apoptotic neutrophils by efferocytosis, which leads to several consequences, that is, removing neutrophils and preventing tissue injury, allowing macrophages to utilize neutrophil granule proteins for antimicrobial defense, and altering cytokine production by macrophages [40, 62 ...
... Macrophages phagocyte apoptotic neutrophils by efferocytosis, which leads to several consequences, that is, removing neutrophils and preventing tissue injury, allowing macrophages to utilize neutrophil granule proteins for antimicrobial defense, and altering cytokine production by macrophages [40, 62 ...
STATE OF THE SCIENCE REPORT
... macroscale. For instance, there is more pressure in a small droplet of water than a larger one, because at the microscale, surface tension dominates over gravity. Thus, microscale physics can be leveraged for these unique properties. Dr. David Beebe discussed creating a microscale platform for s ...
... macroscale. For instance, there is more pressure in a small droplet of water than a larger one, because at the microscale, surface tension dominates over gravity. Thus, microscale physics can be leveraged for these unique properties. Dr. David Beebe discussed creating a microscale platform for s ...
human monoclonal antibody technology.
... bead based technology has been utilized to purify a variety of cell populations. Antigen-specific mouse hybridomas have been selected using this approach shortly after somatic cell fusion, reducing efforts involved in the cloning procedure (Horton et al., 1989; Ossendorp et a l . , 1989). The select ...
... bead based technology has been utilized to purify a variety of cell populations. Antigen-specific mouse hybridomas have been selected using this approach shortly after somatic cell fusion, reducing efforts involved in the cloning procedure (Horton et al., 1989; Ossendorp et a l . , 1989). The select ...
An evaluation of the anti-inflammatory properties
... Humin substances have been used as folk remedies for the last 3000 years. Recent studies have shown that humates possess anti-inflammatory properties, but the mechanism of how it affects inflammation is still unclear. In this study the antiinflammatory properties of potassium humate, a water soluble ...
... Humin substances have been used as folk remedies for the last 3000 years. Recent studies have shown that humates possess anti-inflammatory properties, but the mechanism of how it affects inflammation is still unclear. In this study the antiinflammatory properties of potassium humate, a water soluble ...
Structures Common to Different Glycans ...tials of Glycobiology
... the ABO type of transfused red cells is compatible with the recipient’s ABO type. Thus, an A recipient may receive red cells from another A person or from an O person, but not from a person of type B or AB. Blood banks perform typing and crossmatching assays. First, units of red cell products typed ...
... the ABO type of transfused red cells is compatible with the recipient’s ABO type. Thus, an A recipient may receive red cells from another A person or from an O person, but not from a person of type B or AB. Blood banks perform typing and crossmatching assays. First, units of red cell products typed ...
Construction of a recombinant human GM
... A novel cytokine fusion protein was constructed by fusing granulocyte macrophage colony stimulatAbstract ing factor (GM-CSF) with monocyte chemotactic activating factor (MCAF), which acts as a factor directing effector cells (monocytes) to a target site. The recombinant human GM-CSF/MCAF fusion prot ...
... A novel cytokine fusion protein was constructed by fusing granulocyte macrophage colony stimulatAbstract ing factor (GM-CSF) with monocyte chemotactic activating factor (MCAF), which acts as a factor directing effector cells (monocytes) to a target site. The recombinant human GM-CSF/MCAF fusion prot ...
Fusidic Acid 2% Cream - Medicines and Healthcare products
... No new non-clinical data were submitted, which is acceptable given that the application is for a product which is a hybrid generic medicinal product of an originator product that has been in clinical use for over 10 years. The RMS has been assured that acceptable standards of Good Manufacturing Prac ...
... No new non-clinical data were submitted, which is acceptable given that the application is for a product which is a hybrid generic medicinal product of an originator product that has been in clinical use for over 10 years. The RMS has been assured that acceptable standards of Good Manufacturing Prac ...
Lysosomal Enzymes Are Released From Cultured Human
... carcinomas.21 Moreover, Briozzo et al22 showed that cathepsin D is a major acidic protease secreted by breast cancer cells. LAL, in turn, is present in macrophage foam cells in the subendothelial area and deep in the intimal fibrous tissue,23 but there is little in vivo evidence of secretion of LAL. ...
... carcinomas.21 Moreover, Briozzo et al22 showed that cathepsin D is a major acidic protease secreted by breast cancer cells. LAL, in turn, is present in macrophage foam cells in the subendothelial area and deep in the intimal fibrous tissue,23 but there is little in vivo evidence of secretion of LAL. ...
The roles of platelets in inflammation, immunity, wound healing and
... 20]. Additionally, platelet activation by pathogen-associated molecular patterns (via Toll-like receptors, TLRs) leads to the release of other cytokines, such as platelet factor 4 (PF-4), and CCL5 or RANTES (Regulated upon Activation Normal T cell Expressed and Secreted), that leads to recruitment o ...
... 20]. Additionally, platelet activation by pathogen-associated molecular patterns (via Toll-like receptors, TLRs) leads to the release of other cytokines, such as platelet factor 4 (PF-4), and CCL5 or RANTES (Regulated upon Activation Normal T cell Expressed and Secreted), that leads to recruitment o ...
The Aryl Hydrocarbon Receptor in Barrier Organ Physiology
... organs such as skin, gut, lung, and other mucosal tissues that interact with the environment is critical for survival. Furthermore, these barriers are involved in uptake and absorption of nutrients as well as protection of body integrity against chemical, biologic, and physical stress, and more. The ...
... organs such as skin, gut, lung, and other mucosal tissues that interact with the environment is critical for survival. Furthermore, these barriers are involved in uptake and absorption of nutrients as well as protection of body integrity against chemical, biologic, and physical stress, and more. The ...
High acid phosphatase level in the gingival tissues of periodontitis
... hyperlipidemia, oral hygiene, diet, alcohol etc., are some of the risk factors for periodontitis.[5] Periodontitis is associated with elevated systemic inflammatory markers and production of several lysosomal enzymes. Damaged cells of periodontal gingival tissues can cause a discharge of lysosomal e ...
... hyperlipidemia, oral hygiene, diet, alcohol etc., are some of the risk factors for periodontitis.[5] Periodontitis is associated with elevated systemic inflammatory markers and production of several lysosomal enzymes. Damaged cells of periodontal gingival tissues can cause a discharge of lysosomal e ...
Immune modulation of some autoimmune diseases: the critical role
... bone marrow storage and release, intravascular transit, and destruction [14]. Therefore, after the neutrophil production, development and storage in the bone marrow, its releasing includes a transcellular migration from the sinusoidal endothelium to the circulation [14, 16]. Then, among existing mec ...
... bone marrow storage and release, intravascular transit, and destruction [14]. Therefore, after the neutrophil production, development and storage in the bone marrow, its releasing includes a transcellular migration from the sinusoidal endothelium to the circulation [14, 16]. Then, among existing mec ...
Case 2 - Ipswich-Year2-Med-PBL-Gp-2
... • Is there any bone pain? Prostate cancer often spreads to the bones early, and bone pain may be the first symptom. The pain is usually localized, constant, and severe, and it may be worse with movement • Is there any pain on ejaculation or blood in the ejaculate? These symptoms do not necessarily i ...
... • Is there any bone pain? Prostate cancer often spreads to the bones early, and bone pain may be the first symptom. The pain is usually localized, constant, and severe, and it may be worse with movement • Is there any pain on ejaculation or blood in the ejaculate? These symptoms do not necessarily i ...
Chapter 1 General introduction
... a wide variety of proteinases and reactive oxygen species to kill bacteria and clear damaged matrix proteins23,26. Neutrophil infiltration normally lasts for only a few days. At a later stage during inflammation (day 3-5), when the number of neutrophils declines, macrophages (blood-derived monocytes ...
... a wide variety of proteinases and reactive oxygen species to kill bacteria and clear damaged matrix proteins23,26. Neutrophil infiltration normally lasts for only a few days. At a later stage during inflammation (day 3-5), when the number of neutrophils declines, macrophages (blood-derived monocytes ...
Monomers Peptidoglycan, but Not to Peptidoglycan Respond
... Copyright Ó 2011 by The American Association of Immunologists, Inc. 0022-1767/11/$16.00 ...
... Copyright Ó 2011 by The American Association of Immunologists, Inc. 0022-1767/11/$16.00 ...
the role of the c5a receptor in host defense against listeria
... food poisoning continues to be a major problem today. As many as 1 in 6 Americans are sickened annually by contaminated food (2, 3). One of the most serious foodborne illnesses is listeriosis. The causative agent of listeriosis is the Gram positive bacillus Listeria monocytogenes (Lm). While Lm was ...
... food poisoning continues to be a major problem today. As many as 1 in 6 Americans are sickened annually by contaminated food (2, 3). One of the most serious foodborne illnesses is listeriosis. The causative agent of listeriosis is the Gram positive bacillus Listeria monocytogenes (Lm). While Lm was ...
Cell Systems to Investigate the Impact of Polyphenols on
... HDL) is not considered as a biomarker as such, in which its presence or absence is reflecting injury or damage, but it is an abundant and natural metabolite in blood, whose quantitative variation reflects various metabolic states that are in turn reflective of cardiovascular diseases. In addition, H ...
... HDL) is not considered as a biomarker as such, in which its presence or absence is reflecting injury or damage, but it is an abundant and natural metabolite in blood, whose quantitative variation reflects various metabolic states that are in turn reflective of cardiovascular diseases. In addition, H ...
Human-specific evolution of killer cell immunoglobulin
... immunity—combined with the segregation on different chromosomes of variable NK-cell receptors and their MHC class I ligands—drive an unusually rapid evolution that has resulted in unprecedented levels of species specificity, as first appreciated from comparison of mice and humans. Counterparts to hu ...
... immunity—combined with the segregation on different chromosomes of variable NK-cell receptors and their MHC class I ligands—drive an unusually rapid evolution that has resulted in unprecedented levels of species specificity, as first appreciated from comparison of mice and humans. Counterparts to hu ...
Neutrophils in tuberculosis
... of mice it takes 4 hours for skin infiltration with the same challenge study as that of rabbit [14]. Mechanism of recruitment: In sensitized animals there is a powerful immune response to mycobacterial challenge [11]. Interleukin 17 (IL 17) and IL 23 produced from T helper 17 (Th 17) cell are the ke ...
... of mice it takes 4 hours for skin infiltration with the same challenge study as that of rabbit [14]. Mechanism of recruitment: In sensitized animals there is a powerful immune response to mycobacterial challenge [11]. Interleukin 17 (IL 17) and IL 23 produced from T helper 17 (Th 17) cell are the ke ...
Profiling adaptive immune repertoires across multiple human tissues
... (J) gene segments, and inserts or deletes non-templated bases at the recombination junctions1 (Figure 1a). The resulting DNA sequences are then translated into the antigen receptor proteins. This process allows for an astonishing diversity of the lymphocyte repertoire (i.e., the collection of an ...
... (J) gene segments, and inserts or deletes non-templated bases at the recombination junctions1 (Figure 1a). The resulting DNA sequences are then translated into the antigen receptor proteins. This process allows for an astonishing diversity of the lymphocyte repertoire (i.e., the collection of an ...
Excludes Superantigen-Like Recognition Complementarity
... 14). In these complexes the CDR3s of both TCR chains are located mainly over the central part of the peptide, whereas CDR1 and CDR2 of the two chains may contact both peptide- and MHCdefined determinants. Activation of TCR by superantigens, in contrast, occurs mainly through the CDR1, CDR2, and HV4 ...
... 14). In these complexes the CDR3s of both TCR chains are located mainly over the central part of the peptide, whereas CDR1 and CDR2 of the two chains may contact both peptide- and MHCdefined determinants. Activation of TCR by superantigens, in contrast, occurs mainly through the CDR1, CDR2, and HV4 ...
Platelets (thrombocytes) – the other recognized functions A - CEON-a
... Soluble and membrane-fractalkine can induce degranulation and expression of Pselectin on platelet surface. In this way, formed P-selectin directly leads to an interaction of leukocytes and platelets [14, 16, 17]. Besides the role in the activation of platelets αIIbβ3 and CD40L platelets also have a ...
... Soluble and membrane-fractalkine can induce degranulation and expression of Pselectin on platelet surface. In this way, formed P-selectin directly leads to an interaction of leukocytes and platelets [14, 16, 17]. Besides the role in the activation of platelets αIIbβ3 and CD40L platelets also have a ...
INDUCTION OF INNATE IMMUNE RESPONSES BY PLANT
... 2.6 Polyphenols with TLR-Modulating Activity .............................................................. 50 2.7 Examples of Pro-Inflammatory and Anti-Inflammatory Responses to OPCs ............ 52 3.1 Immune-Relevant Genes with Greater than 3-fold Induction after Treatment of Bovine γδ T Cells wi ...
... 2.6 Polyphenols with TLR-Modulating Activity .............................................................. 50 2.7 Examples of Pro-Inflammatory and Anti-Inflammatory Responses to OPCs ............ 52 3.1 Immune-Relevant Genes with Greater than 3-fold Induction after Treatment of Bovine γδ T Cells wi ...
The Role of Inflammatory Mediators in the Pathogenesis of Otitis
... arachidonic acid metabolism in both cyclooxygenase and lipoxygenase pathways (21, 31). IL-1 is primarily synthesized by activated macrophages. In these, IL-1 production is stimulated by LPS and leukotrienes (28, 32, 33). TNF also stimulates synthesis of IL-1 (14). Platelet activating factor (PAF) ca ...
... arachidonic acid metabolism in both cyclooxygenase and lipoxygenase pathways (21, 31). IL-1 is primarily synthesized by activated macrophages. In these, IL-1 production is stimulated by LPS and leukotrienes (28, 32, 33). TNF also stimulates synthesis of IL-1 (14). Platelet activating factor (PAF) ca ...
Transferrin and the Transferrin Receptor: Of Magic Bullets
... cells express Trf receptor contrasting with resting cells in which the expression is absent or extremely rare [49]. During inflammation monocytes leave the blood and differentiate into macrophages at the extra vascular tissues, macrophages express surface Trf receptors [50-53]. T cell differentiatio ...
... cells express Trf receptor contrasting with resting cells in which the expression is absent or extremely rare [49]. During inflammation monocytes leave the blood and differentiate into macrophages at the extra vascular tissues, macrophages express surface Trf receptors [50-53]. T cell differentiatio ...
12-Hydroxyeicosatetraenoic acid
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a Hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z Cis–trans isomerism configuration (Z=cis, E=trans) in its four double bonds. It was first found as a product of arachidonic acid metabolism made by human and bovine platelets. However, the term 12-HETE is ambiquous in that it has been used to indicate not only the initially detected ""S"" stereoisomer, 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HETE or 12S-HETE), made by platelets, but also the later detected R stereoisomer, 12(R)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(R)-HETE or 12R-HETE) made by other tissues. The two isomers, either directly or after being further metabolized, have been suggested to be involved in a variety of human physiological and pathological reactions. Unlike hormones which are secreted by cells, travel in the circulation to alter the behavior of distant cells, and thereby act as Endocrine signalling agents, these arachidonic acid metabolites act locally as Autocrine signalling agents to regulate the behavior of their cells of origin or as Paracrine signalling agents to regulate the function of nearby cells. In these roles, they may amplify or dampen, expand or contract cellular and tissue responses to disturbances.