Platelet-derived CD154 enables T-cell priming and
... function. Consequently, FcR␥⫺/⫺ mice fail to express GPVI in their platelets and the cells are unresponsive to collagen.37 In addition in normal mice, intravenous injection of soluble collagen induces a rapid and fatal thromboembolism that is entirely dependent upon the ability of platelets to be ac ...
... function. Consequently, FcR␥⫺/⫺ mice fail to express GPVI in their platelets and the cells are unresponsive to collagen.37 In addition in normal mice, intravenous injection of soluble collagen induces a rapid and fatal thromboembolism that is entirely dependent upon the ability of platelets to be ac ...
Roles of dopamine receptor subtypes in
... lymphocytes is shown a possibility underlying mechanisms of dopamineinduced cell proliferation. Dopamine receptors have been isolated, characterized and subdivided into two families, D1-like and D2-like receptors, on the basis of their biochemical and pharmacological properties (Vallone et al. 2000) ...
... lymphocytes is shown a possibility underlying mechanisms of dopamineinduced cell proliferation. Dopamine receptors have been isolated, characterized and subdivided into two families, D1-like and D2-like receptors, on the basis of their biochemical and pharmacological properties (Vallone et al. 2000) ...
Helicobacter pylori bacteria: Tools for Eradication
... flavonoids, triterpene saponins, isoflavonoids and hydroxycoumarins. Of these, the component possessing the greatest activity is the triterpenoid saponin glycyrrhizin (GL), having demonstrated antiviral53, 54, 55, 56 antimicrobial57 and antifungal58,59 properties. In animal studies GL was demonstrat ...
... flavonoids, triterpene saponins, isoflavonoids and hydroxycoumarins. Of these, the component possessing the greatest activity is the triterpenoid saponin glycyrrhizin (GL), having demonstrated antiviral53, 54, 55, 56 antimicrobial57 and antifungal58,59 properties. In animal studies GL was demonstrat ...
The heparin-binding domain confers diverse functions of VEGF
... experimental diabetes, with the VEGF164 isoform accounting for 80 % of total VEGF-A detected [42,43]. VEGF-A may also act directly on certain cells of the immune system, including monocytes, lymphocytes and dendritic cells, as ...
... experimental diabetes, with the VEGF164 isoform accounting for 80 % of total VEGF-A detected [42,43]. VEGF-A may also act directly on certain cells of the immune system, including monocytes, lymphocytes and dendritic cells, as ...
GNLD - News You Can Use - Fats, the Good, Bad and
... too frequently, can lead to body fat gain. This type of fat has also been linked to increased blood cholesterol levels, which leads to clogging of the arteries – especially those feeding the heart itself. Figure 1a ...
... too frequently, can lead to body fat gain. This type of fat has also been linked to increased blood cholesterol levels, which leads to clogging of the arteries – especially those feeding the heart itself. Figure 1a ...
2016A Guerreiro Microbial Cell
... mM for S. cerevisiae [6-8]. Depending on the acid concentration, acetic acid may induce a PCD either with an apoptotic or a necrotic phenotype [6-8]. In S. cerevisiae, acetic acid - induced PCD with an apoptotic phenotype is known to be mediated by mitochondria, an organelle that fulfills crucial fu ...
... mM for S. cerevisiae [6-8]. Depending on the acid concentration, acetic acid may induce a PCD either with an apoptotic or a necrotic phenotype [6-8]. In S. cerevisiae, acetic acid - induced PCD with an apoptotic phenotype is known to be mediated by mitochondria, an organelle that fulfills crucial fu ...
Lactobacillus acidophilus 48-1e TM
... same level as that induced by lipopolysaccharides (LPS) (20). These results are in accordance with those obtained with living cells (see above). T hey also indicate the possible role of pure bacterial DNA in probiotic efficacy. Animal studies Using the cytokine expression data as a predictive test ...
... same level as that induced by lipopolysaccharides (LPS) (20). These results are in accordance with those obtained with living cells (see above). T hey also indicate the possible role of pure bacterial DNA in probiotic efficacy. Animal studies Using the cytokine expression data as a predictive test ...
FACTORS INFLUENCING PROSTATE CANCER Review Article SANDEEP SINGH
... progression. Cytokine production by the cells of the immune system may occur through antigen-specific and non-antigen specific stimuli. For example, monocytes when exposed to bacterial cell wall products such as lipopolysaccharide produce IL-12 and other cytokines which have multiple functions inclu ...
... progression. Cytokine production by the cells of the immune system may occur through antigen-specific and non-antigen specific stimuli. For example, monocytes when exposed to bacterial cell wall products such as lipopolysaccharide produce IL-12 and other cytokines which have multiple functions inclu ...
Functional Characterization of the CD300e Leukocyte Receptor Tamara Brckalo
... TNF-α, IL-1β, CXCL8, IL-6, and IL-10), vascular endothelial growth factor and proteolytic enzymes [10]. Even though antigen presentation has been described as a functional feature of monocytes, they have been found to be far less efficient than DCs [24]. Monocytes have some typical morphological fea ...
... TNF-α, IL-1β, CXCL8, IL-6, and IL-10), vascular endothelial growth factor and proteolytic enzymes [10]. Even though antigen presentation has been described as a functional feature of monocytes, they have been found to be far less efficient than DCs [24]. Monocytes have some typical morphological fea ...
Localization of Receptors for Vasoactive Intestinal
... peptides, have been shown to be involved in the regulation of immune processes in numerous animal and human studies.1-3 First, receptors for various regulatory peptides, ie, somatostatin (SS), vasoactive intestinal peptide (VIP), or substance P (SP) are expressed by rat, mice, or human immunocytes, ...
... peptides, have been shown to be involved in the regulation of immune processes in numerous animal and human studies.1-3 First, receptors for various regulatory peptides, ie, somatostatin (SS), vasoactive intestinal peptide (VIP), or substance P (SP) are expressed by rat, mice, or human immunocytes, ...
Endometrial Receptivity to Implantation in Humans
... The success rate of several advanced basic and clinical techniques in the field of mammalian biotechnology, including cloning, pre-implantation genetic diagnosis, and assisted reproductive techniques (ART) depends mainly on the success rate of pregnancy following in vitro fertilization-embryo transf ...
... The success rate of several advanced basic and clinical techniques in the field of mammalian biotechnology, including cloning, pre-implantation genetic diagnosis, and assisted reproductive techniques (ART) depends mainly on the success rate of pregnancy following in vitro fertilization-embryo transf ...
- 13th International Workshop on Langerhans Cells
... the 13th International Workshop on Langerhans Cells in Amsterdam, The Netherlands. LC2013 provides the great opportunity to listen to international experts to hear their latest news and their opinions. The meeting will take place from Thursday, October 10th to Sunday, October 13th, 2013 at the Ro ...
... the 13th International Workshop on Langerhans Cells in Amsterdam, The Netherlands. LC2013 provides the great opportunity to listen to international experts to hear their latest news and their opinions. The meeting will take place from Thursday, October 10th to Sunday, October 13th, 2013 at the Ro ...
Biosynthesis of estradiol. Cloning and characterization of rodent
... study the role of rodent type 1 enzyme in ovarian estradiol (E2) biosynthesis and its enzymatic characteristics. Both rat and mouse 17HSD/KSR1 were expressed in granulosa cells of developing follicles, where diethylstilbestrol and follicle-stimulating hormone stimulated follicular maturation and up- ...
... study the role of rodent type 1 enzyme in ovarian estradiol (E2) biosynthesis and its enzymatic characteristics. Both rat and mouse 17HSD/KSR1 were expressed in granulosa cells of developing follicles, where diethylstilbestrol and follicle-stimulating hormone stimulated follicular maturation and up- ...
Inflammatory lipid mediators in adipocyte function and obesity
... is that chronic macronutrient and/or lipid overload (associated with adiposity) induces cellular stress that initiates and perpetuates an inflammatory cycle and pathophysiological signaling of immunoinflammatory cells and adipocytes. Many lipid mediators exert their biological effects by binding to ...
... is that chronic macronutrient and/or lipid overload (associated with adiposity) induces cellular stress that initiates and perpetuates an inflammatory cycle and pathophysiological signaling of immunoinflammatory cells and adipocytes. Many lipid mediators exert their biological effects by binding to ...
Human Pancreatic Cancer Cells Induce a MyD88
... The desmoplastic response in pancreatic cancer is associated with the production of IL6 and IL8 Circulating concentrations of IL8 and IL6 have been identified as diagnostic and prognostic markers for both pancreatitis and pancreatic cancer (21). We first confirmed that higher concentrations of both IL8 ...
... The desmoplastic response in pancreatic cancer is associated with the production of IL6 and IL8 Circulating concentrations of IL8 and IL6 have been identified as diagnostic and prognostic markers for both pancreatitis and pancreatic cancer (21). We first confirmed that higher concentrations of both IL8 ...
Double-Stranded RNA Induces an Antiviral Defense Status in
... of antiviral pattern recognition molecules in human keratinocytes and analyze their specific role in the induction of antiviral mediators. Using foreskin-derived cultured primary human keratinocytes we were able to depict the hierarchy of response patterns to the synthetic dsRNA analog poly(I:C). We ...
... of antiviral pattern recognition molecules in human keratinocytes and analyze their specific role in the induction of antiviral mediators. Using foreskin-derived cultured primary human keratinocytes we were able to depict the hierarchy of response patterns to the synthetic dsRNA analog poly(I:C). We ...
Not Signaling Mechanisms of Innate Immune Sensing but Human
... the expression of individual TLRs in dendritic cells depends upon their subtype (9, 10). The microbial agonists for TLRs include a wide variety of structures. For example, TLRs 3, 7, 8, and 9 collectively respond to nucleic acids from bacteria and viruses, and these intracellular family members indu ...
... the expression of individual TLRs in dendritic cells depends upon their subtype (9, 10). The microbial agonists for TLRs include a wide variety of structures. For example, TLRs 3, 7, 8, and 9 collectively respond to nucleic acids from bacteria and viruses, and these intracellular family members indu ...
First Line of Defense in Early Human Life
... aureus, which is a main cause of lactational mastitis. Further studies remain to be conducted to clarify the regulation of HBD1 expression in breast milk, and the influence of breastfed-mediated antimicrobial peptides in newborn during or after lactation. ...
... aureus, which is a main cause of lactational mastitis. Further studies remain to be conducted to clarify the regulation of HBD1 expression in breast milk, and the influence of breastfed-mediated antimicrobial peptides in newborn during or after lactation. ...
Cross-Talk between Cancer Cells and the Tumour
... BLT1 is a high affinity receptor for LTB4 expressed primarily by leukocytes whereas BLT2 is a low affinity receptor for both LTB4 and 12-HETE expressed more ubiquitously [60]. CystLT receptors have been reported in T-lymphocytes, eosinophils, mononuclear cells, macrophages and in certain cases neutr ...
... BLT1 is a high affinity receptor for LTB4 expressed primarily by leukocytes whereas BLT2 is a low affinity receptor for both LTB4 and 12-HETE expressed more ubiquitously [60]. CystLT receptors have been reported in T-lymphocytes, eosinophils, mononuclear cells, macrophages and in certain cases neutr ...
NOG Mice Transgenic − Using Human IL-3/GM
... system, enormously improving the generation of humanized mice. Our group previously demonstrated that efficient human hematopoiesis could be seen in NOG mice upon transplantation of human hematopoietic stem cells (HSCs; hu-HSC NOG mice) (17, 23). In particular, lymphopoiesis was evident, and human B ...
... system, enormously improving the generation of humanized mice. Our group previously demonstrated that efficient human hematopoiesis could be seen in NOG mice upon transplantation of human hematopoietic stem cells (HSCs; hu-HSC NOG mice) (17, 23). In particular, lymphopoiesis was evident, and human B ...
Glycosylation and Fc Receptors
... be membrane bound in the form of surface immunoglobulins or soluble. Surface immunoglobulins form part of the B-cell receptor (BCR) and are composed of membrane bound immunoglobulin D (IgD) or immunoglobulin M (IgM). This allows the antibody producing B-cell to detect specific antigens resulting in ...
... be membrane bound in the form of surface immunoglobulins or soluble. Surface immunoglobulins form part of the B-cell receptor (BCR) and are composed of membrane bound immunoglobulin D (IgD) or immunoglobulin M (IgM). This allows the antibody producing B-cell to detect specific antigens resulting in ...
Impaired Cytokine Signaling in Mice Lacking the IL
... IRAK is also involved in IL-18 signal transduction. Though its amino acid sequence and chromosomal localization differ from those of IL-1a, IL-1b, and the IL-1Ra, IL-18 shares structural features with these IL-1 family members (17, 18). In conjunction with IL-12, IL-18 supports Th1 lymphocyte develo ...
... IRAK is also involved in IL-18 signal transduction. Though its amino acid sequence and chromosomal localization differ from those of IL-1a, IL-1b, and the IL-1Ra, IL-18 shares structural features with these IL-1 family members (17, 18). In conjunction with IL-12, IL-18 supports Th1 lymphocyte develo ...
Evaluating the efficacy, safety and possible selenium
... Aim. The aim of the study was to evaluate the efficacy, safety and possible mechanism of action of potassium humate loaded with selenium Objectives. The objectives of the study were to evaluate the possible in vitro cytotoxic effect of potassium humate loaded with selenium (Phse) on the growth of pr ...
... Aim. The aim of the study was to evaluate the efficacy, safety and possible mechanism of action of potassium humate loaded with selenium Objectives. The objectives of the study were to evaluate the possible in vitro cytotoxic effect of potassium humate loaded with selenium (Phse) on the growth of pr ...
12-Hydroxyeicosatetraenoic acid
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a Hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z Cis–trans isomerism configuration (Z=cis, E=trans) in its four double bonds. It was first found as a product of arachidonic acid metabolism made by human and bovine platelets. However, the term 12-HETE is ambiquous in that it has been used to indicate not only the initially detected ""S"" stereoisomer, 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HETE or 12S-HETE), made by platelets, but also the later detected R stereoisomer, 12(R)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(R)-HETE or 12R-HETE) made by other tissues. The two isomers, either directly or after being further metabolized, have been suggested to be involved in a variety of human physiological and pathological reactions. Unlike hormones which are secreted by cells, travel in the circulation to alter the behavior of distant cells, and thereby act as Endocrine signalling agents, these arachidonic acid metabolites act locally as Autocrine signalling agents to regulate the behavior of their cells of origin or as Paracrine signalling agents to regulate the function of nearby cells. In these roles, they may amplify or dampen, expand or contract cellular and tissue responses to disturbances.