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What is Nucleotide Nutrition?
Nucleotides are organic compounds that form the essential
building blocks for nucleic acids (information-containing
molecules) such as DNA (Deoxyribo Nucleic Acid) and RNA
(Ribo Nucleic Acid).
What are the functions of nucleotides?
Besides being the building blocks for DNA and RNA, nucleotides
are involved at a cellular level*. Nucleotides are essential for:
a) transfer of energy
b) production of protein
c) mediation of hormone signals
*Nucleotides consist of a nitrogen-containing base, a pentose sugar and one to three
phosphate groups. The DNA molecule consists of nucleotides in which the sugar component is
deoxyribose and the RNA molecule consists of nucleotides in which the sugar is ribose.
Nucleotides are divided into two groups:
a) purines, double ringed structures; and
b) pyrimidines, single-ringed structures.
In DNA, the purine base consists of Adenine (A) and Guanine (G), while the pyrimidine base
consists of Thymine (T) and Cytosine (C). RNA consists of Adenine (A), Guanine (G) while the
pyrimidine consists of Cytosine (C), and instead of Thymine (T), Uracil (U) is present.
The DNA in a cell consists of a long pattern made up of four different nucleotide bases.
The outside spine of DNA consists of sugar and phosphate portions of the nucleotides, while
the middle parts (or steps) are made of complementary pairs of nitrogenous bases-(G with C, A
with T...) and held together by weak hydrogen bonds. It is this hydrogen bond between
phosphates that gives DNA its characteristic twist.
3 billion nucleotides are required to build each cell’s DNA.
What is the importance of nucleotides in terms of the digestive system?
Cells in the body that have a high turnover rate have a higher requirement for
nucleotide supplementation:
a) white blood cells.
b) cells in the wall of the small intestine (intestinal mucosa cells).
c) “good” gut microflora (e.g. bifidobacteria)
All of which are key to immune strength and a healthy digestive system.
What is the role of “villi” in the digestive system and presence in small versus large
intestine?
The nutrient absorption in the small intestine is conducted by the “villi”. The “villi” are
microscopic intrusions into the small intestine which are covered with epithelial cells
responsible for the absorption of nutrients and on transfer into the blood stream. These
epithelial cells have a lifespan of three to five days and require nucleotide nutrition to
assist in their replacement via DNA replication.
The large intestine does not contain “villi” but handles the absorption of water and the
breakdown of fibre by bacteria.
Which digestive disorders can damage compromise the function of the “villi” in the
small intestine?
Digestive systems are compromised by disorders like:


Celiac disease
Ulcerative Colitis


Crohn’s disease
Irritable Bowel Syndrome (IBS)
These disorders reduce the vital absorptive cell surface area of the “villi” and have a
damaging effect on the overall digestive system.
These disorders create inflammation that damage the “villi” creating small lesions. For
the body to repair this damage it requires significantly more nucleotides than for normal
maintenance purposes.
How does nucleotide nutrition in the form of IntestAid®IB promote cell replication
which is key to healthy digestive function?
Today´s diets generally provide plenty of purines, but unfortunately the normal diet is
deficient in pyrimidine nucleotides. There are more pyrimidines than purine nucleotides
in IntestAid®IB and this nucleotide ratio is essential to cellular replication which in turn
promotes healthy digestive function by:
a) Assisting normal cell division to assist in the creation of new cells in the lining
of the gut.
b) Aiding the maintenance and repair of the intestinal lining.
c) Contributing to energy levels (cellular energy; ATP Adenosine Triphosphate)
d) Helping to protect cells from oxidative stress
e) Contributing to the metabolism of iron in the body
f) Assisting protein and amino acid synthesis.
What is the supplementation schedule for IntestAid®IB in children
(2 years and older)
Supplementation
Schedule
Week
IntestAid IB®
1 capsule /day
1
7
2
7
3
7
4
7
5
7
6
7
7
7
8
7
9
7
10
7
Total
Packs
60 caps/pack
84
1.4
11 12
7 7
What are the nutritional facts for IntestAid® IB?
1 capsule
(500mg)
%
RDA*
Vitamins:
Riboflavin
Folate (as pteroylmonoglutamic acid)
Pantothenic acid (as calcium d-pantothenate)
Biotin (as d-biotin)
2.25 mg
200 μ g
6 mg
94 μ g
159,5%
100%
100%
188%
Nucleotides:
RNA Nucleotides from (Saccharomyces cerevisiae)
139 mg
†
Amino acids:
L-glutamine
L-lysine
L-methionine
106 mg
37.5 mg
27 mg
†
†
†
Other:
Fructo-oligosaccharides
FOS (from chicory roots)
Inositol
Sodium citrate
93.5 mg
40 mg
10 mg
†
†
†
Nutritional Facts
* RDA-Recommended daily allowance
† RDA not yet established
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