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Student Name: _____________________________ Date: ____________________ What does DNA do? Activity 1 - Base Pairs ___ 1) Get a base pair. What is the name on the back? Look at its shape. Walk around the room and find someone that you can match up with to make a rectangle. ___ 2) Look at how people matched up. What rule can you come up with for the base pairs? Write this rule down. Rule: Adenine always pairs with Thymine (or Uracil for RNA) Guanine always pairs with Cytosine This is the Base Pair Rule! Activity 2 - Replication ___ 1) Get a strand of DNA from your teacher. ___ 2) Unzip the strand so you have two separate ones. ___ 3) Follow the base pair rule to fill in the missing base pairs for each strand. ___ 4) Compare your strands. Are they similar? What have you done? Where did this process take place in the cell? Why is this process important? They are identical copies of each other (mirror images). This process takes place in the nucleus before cell division, so that each new cell has a copy of the DNA. -1– Student Name: _____________________________ Date: ____________________ Activity 3 -Transcription and Translation ___ 1) Use the amino acid chart to write out a code that spells a word that is between 8-10 letters long. There are no letters B, J, O, U, X, or Z! Word CLARK mRNA Strand UGU CUU GCU CGU AAA DNA Strand (Base Pairs) ACA GAA CGA GCA TTT ___ 2) Exchange your code with someone else in the class. ___ 3) Write down the code you received below: DNA Strand: ACA GAA CGA GCA TTT ___ 4) Take the code you have been given and transcribe it into an mRNA strand. Record your code below: * *Remember, RNA uses Uracil instead of Thymine** mRNA Strand: UGU CUU GCU CGU AAA -2– Student Name: _____________________________ Date: ____________________ ___ 5) Where in the cell are you located now? Still in the nucleus ___ 6) Take your mRNA strand and translate it by matching it up with the correct amino acid. Record this below and write the letter for the each amino acid. Where does this take place. Amino Acid Code: UGU = C CUU = L GCU = A CGU = R AAA = K The mRNA moves from nucleus into the cytoplasm ___ 6) What word did you spell out? Check with the person to see if you are correct? What does this name represent CLARK This name represents a protein (a chain of amino acids) ___ 7) Did you or anyone else make a mistake? What do we call this when a cell does it? -3–