Download The Central Dogma Activity (Student Sheet)

The Central Dogma Activity (Student Sheet)
Name: ________________________________________ Date: _________
Partner Name: __________________________________ Period: ________
Original DNA Sequence: #_____
The objective of this lesson is to explore and then demonstrate the principle of The Central Dogma. By the
end of the activity, you should be able to identify and explain the relationship between DNA and protein by
describing the three processes involved in the Central Dogma as well as explain the possible consequences if a
mistake occurs during these processes.
Materials you will need to complete this activity:

1 nucleus/ribosome + codon table sign

1 of the pre-printed DNA sequences (Template Strand)

1 blank complementary DNA strand (blank)

1 green RNA strand

5 blue tRNA molecules

1 yellow polypeptide strand

Dry erase marker, towels
**All materials must be properly cleaned and organized before you leave your lab station. You must ask to get
a clean-up stamp before you leave your station**
Part I
Original Amino Acid Sequence (you will need to get the parts you don’t have from other groups)
1-1
1-2
1-3
1-4
1-5
2-1
2-2
2-3
2-4
2-5
3-1
3-2
3-3
3-4
3-5
4-1
4-2
4-3
4-4
4-5
Part II
Mutated Amino Acid Sequence (you will need to get the parts you don’t have from other groups)
1-1
1-2
1-3
1-4
1-5
2-1
2-2
2-3
2-4
2-5
3-1
3-2
3-3
3-4
3-5
4-1
4-2
4-3
4-4
4-5
Answer Analysis Questions as you go using complete sentences. Please put a title for each section of Analysis
Questions.
Replication Analysis Questions #1-5
Transcription Analysis Questions #1-10
Translation Analysis Questions #1-9
Mutations Analysis Questions #1-6