Download BIO C211 - BITS Pilani

BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, PILANI (RAJ.)
INSTRUCTION DIVISION
Course Handout (Part II)
In addition to Part One (General Handout for all courses appended to the time table) this part gives
further specific details regarding the course.
Course No.
: BIO C211
Course Title
: Biological Chemistry
1. Scope & objective of the Course: Biochemistry has been undergoing transition, stimulated by
new experimental findings and new insights. Molecular understanding of genetics, has
transformed the biological sciences and has given a new direction of teaching and research.
Biochemistry is the language of biology. Therefore, this course is introduced at the cellular and
molecular level and focuses upon biomacromolecules, biosynthesis of macromolecules, energy
yielding and energy requiring processes, genetic information etc. This would help going for higher
level activities, appreciation of biochemical problems, evaluation and problem solving.
2. Text Book : Conn, Eric E. et al, Outlines of Biochemistry, WIE, 5th Ed., 1987.
Reference Book : Lehninger, A.L., Biochemistry, Worth Publishers
H.F. Gillbert, Basic concepts in Biochemistry, 1992, McGraw-Hill.
Donald Voet et. al., Biochemistry, Wiley, 1993.
3. Course Plan:
Topic
No. of Lect.
Chemistry of Biomolecules
9 Ch.
1. Carbohydrates
2. Lipids
3. Protein, structure & function, protein folding & conformation,
Synthesis & regulations
4. Nucleic acids, Genomic structure & function, systhesis
B. Enzymes
4 Ch.
1. Classification
2. Enzyme kinetics
3. Enzyme inhibitors and regulators
4. Allosteric enzymes
5. Multienzyme systems
6. Isoenzymes
C. Vitamins and coenzymes
3 Ch.
1. Classification of vitamins
2. Structures and functions of some important vitamins.
D. Biochemical Energetics
3 Ch.
1. The concept of free energy
2. Energy rich compounds
3. Coupling of reactions
4. Oxidation-Reduction
E. Carbohydrate Metabolism
9 Ch.
1. Glycolysis
2. Reversal of Glycolytic sequence
Ref. to text
2,3,6,7
4
5
9
10,11 and 12
3. Utilization of carbohydrates
4. Regulation of Glycolysis
5. Pentose Phosphate Pathway
6. TCA cycle
7. Glyoxylic acid cycle
F. Biological Oxidations
3 Ch.
1. Components involved in ETC
2. The Respitatory chain
3. Oxidative phosphorylation and its mechanisms
G. Photosynthesis - The process of energy Conversion 2 Ch.
1. Introduction
2. Path of carbon - calvin cycle
3. C4 pathway
H. Lipid Metabolism
5 Ch.
1. Hydrolysis and transport of fats
2. B -oxidation
3. Oxidation of unsaturated fatty acids
4. Formation of Ketone bodies
5. Biosynthesis of fatty acids
I. Amino acid and Protein Metabolism
3 Ch.
1. Catabutisr of Amino acids
2. Assimilation of ammonia
3. Urea cycle and formation of uric acid
J. Nucleic Acid Metabolism
3
1. Purine biosynthesis
2. Pyrimidine biosynthesis
3. Salvage pathway
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-------4. Evaluation Scheme:
Component
Duration Weightage Date Time & Venue
Test I
50 min
15
Test II
50 min
15
Quiz (4)
20
Assignment
Seminar
Comprehensive
Exam.
3 hours
14
15
13
17
-do-
Remarks
CB
OB
Best four
out of Six
10
10
30
CB
5. Chamber Consultation Hour: To be announced in the class.
6. Notices: All notices will be displayed on Biosciences and F.D.III Notice Boards.
Instructor-in-charge
BIO C211