Download Biochemistry

COURSE GUIDE
DEGREE
DEGREE: MEDICINE
ACADEMIC YEAR 2016/2017
COURSE: 1
st
Course Title
BIOCHEMISTRY
ECTS
Type
Total
Basic
6
X
Obligatory
Period
Optional
er
1 C
2ºC
Calendar
Pre-requisites
Weeks
X
Course Language
Spanish
Valenciano
English
X
Departament
Biomedical Sciences
French
Specific Area of knowledge
Biochemistry and Molecular Biology (Health Sciences)
Course Coordinator and other Professors
Ignacio Pérez Roger (coordinator)
Name
Enric Poch Jiménez
José R. Penadés Casanova
st
Office / Faculty
1 floor; Building: Seminario
Email
[email protected]
[email protected]
[email protected]
Student appointment schedule
Every day, 13:00-14:15 (after booking an appointment)
Introduction to the Course
Biochemistry is the study of the molecular basis of life. This subject aims to provide students with the
fundamental knowledge to understand the molecular basis of biology and its subsequent implementation and
relationship with other subjects such as physiology, pathology and nutrition.
In the first part of the course we will describe the structures of the major biomolecules and their physical and
chemical properties, with particular emphasis on the structure / function.
The second part deals with the study of the main metabolic pathways of degradation and biosynthesis of
biomolecules. Special emphasis is placed on the idea of the cell as a metabolic unit in which are integrated and
jointly regulate different metabolic pathways. These topics help students to understand better the basis of
different metabolic diseases and their treatment.
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Pre-requisites
Students should have a good level of biology and chemistry from High School.
Course Objetives
-
To know and understand the structure and function of cells.
To know and understand the composition of the biomolecules in the human body (sugars, lipids and
proteins).
To know and understand the basic principles of metabolism, its regulation and integration and its
relationship with human nutrition.
To know and be able to use laboratory material and techniques.
General and Specific Skills Offered by the Course
General Skills.
General Skill 1 Knowledge Acquisition
Building on the foundations laid during their secondary education and with the support of advanced textbooks,
the students will be able to demonstrate a level of knowledge and understanding equivalent to those at the
forefront of their field of study.
General Skill 2 Application of Knowledge
Students will be able to apply their knowledge to their work or vocation in a professional manner and possess
the skills typically demonstrated through devising and sustaining arguments and solving problems within
epidemiology and public health.
General Skill 3 Collect and Interpret and Analyse Relevant Data
Students will gain the ability to gather and interpret relevant data to inform judgments that include reflection on
social scientific and ethical issues.
General Skill 4 Communication
Students will gain the opportunity to improve their communication skills via dissemination of information, ideas,
problems and solutions to both specialist and non-specialist audiences.
General Skill 5 Independent Learning
Students will be required to develop learning skills necessary to undertake in depth, detailed studies with a high
degree of autonomy
Specific Skills.
B) Scientific basis of medicine:
7. Understand and recognize the normal structure and function of the human body at different levels
(molecular, cellular, tissues, organs and systems) in the different stages of life and in both sexes.
9. Understand and recognize the effects, mechanisms and manifestations of the disease on the structure
and function of the human body.
12. Understanding the causes of action, indications and efficacy of therapeutic interventions, based on the
available scientific evidence.
F) Information management:
31. Understand, critically evaluate and learn to use sources of clinical and biomedical information to obtain,
organize, interpret and communicate scientific and health information.
32. Know how to use information technology and communication in clinical, therapeutic, preventive and
research.
G) Critical analysis and research:
35. Understand the importance and limitations of scientific thinking in the study, prevention and
management of disease.
36. Being able to formulate hypotheses collect and critically evaluate information to solve problems using
the scientific method.
37. Acquire basic training for research activity.
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Course Contents
I.
PRINCIPLES OF STRUCTURAL BIOCHEMISTRY
II. PRINCIPLES OF INTERMEDIARY METABOLISM
Course Structure and Design
Lectures
Training activity oriented mainly to knowledge acquisition (General Skill 1) and representative of the more
theoretical subjects. The priority being the transmission of knowledge from the teacher, the student requires
prior preparation or further study.
Seminars
Training activity that promotes student participation in reasoned interpretation of knowledge and sources in the
study area. Is oriented mainly to application of knowledge (General Skill 2) as well as the ability to gather,
interpret and judge information and data (General Skill 3). It is representative of mixed profile materials or
activities, theoretical-practical.
Practicals
Training activity oriented mainly to application of knowledge (General Skill 2) and representative of the subjects
or practical activities (laboratories, field work, supervised practice, regulated practices, care practices,
practicum, etc..).
Estimation of Student Workload
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NAME OF SUBJECT
Credits ECTS:
6
Breakdown of Student Work Hours
Contact Hours
(A)
Formative Activity
Total Work Hours (C)
Independent
Study (B)
C=A+B
TAUGHT CLASSES
Presentation
1
Theory Classes
36
14
1
50
Laboratory
9
4
13
Practicals in the Computer Lab
3
1
4
Problem Solving
4
1
5
Debates
4
1
5
69
69
Debates
Feedback and Review of Assignments
Others
PRACTICAL CLASSES
Problem Solving
Debates
Feedback and Review of Assignaments
Simulations
Visits
Presentation and discussion about
coursework assignments
Other
SEMINAR CLASSES
Feedback and Review of Assignaments
WORKSHOPS
Feedback and Review of Assignaments
Oral Presentations
COURSEWORK
Preparation time required
EXAMS AND ASSESSMENTS
Exam preparation time
Exams and Tests
3
3
Others
TOTAL
60
90
RELATIONSHIP BETWEEN WORK HOURS AND ECTS CREDITS
(The result of dividing the number of work hours by the number of ECTS credits
assigned for the course should equal 25 hours as this is the value of 1 ECTS credit at
the Universidad CEU Cardenal Herrera)
150
150/25 = 6 ECTS
Assessment Criteria
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Assessment Criteria
Learning assessment is based on continuous evaluation and in a final exam. To pass the subject, the students
must get 5 points out of 10 by adding both parts:





Attending and participation: 5%
Written exams (during the semester): 20%
Case and problem solving: 5%
Practice written exam: 10%
Final exam: 60%
Written exams will consist of 30 test questions (True/False) and 2 short-answer questions in which the students
will need to elaborate a reasoned answer.
Detailed Course Contents
I. PRINCIPLES OF STRUCTURAL BIOCHEMISTRY
1.
Biomolecules. Carbon chemistry. Functional groups.
2.
Water and its effect on the biomolecules in solution. pH and buffers
3.
Sugars. Aldoses and ketoses. Monosaccharides, disaccharides and polysaccharides. Starch and
glycogen.
4.
Lipids. Structure and function of lipids. Fatty acids. Membrane lipids. Lipid signalling. Transport of
lipids in plasma lipoproteins
5.
Proteins. Structure and classification of amino acids. Properties of amino acids. Peptide bond.
Working with proteins
6.
Protein structure: primary, secondary, tertiary and quaternary structures. Native conformation.
7.
Structure-function relationship of proteins: study of haemoglobin.
8.
Enzymology and enzyme kinetics.
9.
Regulation of enzymes: inhibitors, alosteric regulation and covalent modifications.
II. PRINCIPLES OF INTERMEDIATE METABOLISM
10. Introduction. Bioenergetics.
11. Pyruvate dehydrogenase and the Citric acid cycle.
12. Oxidative phosphorylation. ATP synthesis.
13. Glycolysis. Reactions and energy balance. Metabolic fates of pyruvic acid. Pentose phosphate
pathway of glucose oxidation.
14. Carbohydrate biosynthesis: gluconeogenesis.
15. Regulation of carbohydrate metabolism.
16. Fatty acid oxidation. Metabolism of Ketone bodies.
17. Fatty acid biosynthesis. Synthesis and metabolic fates of cholesterol.
18. Metabolism of amino acids. Metabolic fates of amino acids carbons. The urea cycle. Amino acids
degradation and synthesis.
19. Biosynthesis and degradation of nucleotides.
20. Tissue metabolism. Liver metabolism. Adipose tissue. Muscle and brain metabolism.
21. Hormonal regulation and integration of metabolism. Molecular mechanisms of signal transduction.
PRACTICALS
1. Chromatography
2. Enzyme kinetics
3. Digestive enzymes
4. Metabolic simulation
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Basic Bibliography
-
NELSON, DAVID L.; COX, MICHAEL M. Lehninger Principles of Biochemistry. 6th ed. W. H. Freeman
and Company, New York. 2012
-
BERG, JOHN L.; TYMOCZKO, JEREMY M. Biochemistry: A Short Course. 3rd ed. Palgrave
Macmillan, London. 2015
Additional Reading
-
BAYNES, J.; DOMINICZAK, M.H. Medical Biochemistry. 4th ed. Saunders Elsevier, Saint Louis. 2014
-
FERRIER, D.R. Biochemistry, 6th Ed. Lippincott’s Illustrated Reviews Series. Lippincott, Williams &
Wilkins, Baltimore. 2013
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