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DNA Problems When you look at chromosomes in a nucleus you see them as X-shaped structures like these. In the nucleus of our cells, there are 46 chromosomes altogether. Here is what they look like. The 46 chromosomes are actually 23 pairs – one of each pair has come from the mother and the other has come from the father. When you pair them up together you get the karyotype. Here is an example of the human karyotype. Each chromosome is made of long strands of DNA molecule. Sections of the DNA strand which make up a chromosome are called genes. Genes carry the genetic information of characteristics and can be passed on to the next generation – e.g. gene for eye colour, hair colour, etc. In 2003, scientists finished mapping out all the possible genes of a human being – the human genome. Human chromosomes Can you spot what is different about male and female chromosomes? _______________________________________________________ _______________________________________________________ This person has Down’s Syndrome. Can you see what is different about his/her chromosomes? Is this person Male or Female? ___________________________ Fertilisation Fill in the correct number of chromosomes to make a new human being. Complete the statement below showing the percentage of your genes you inherit from your parents. This means that exactly % come from your mother; and exactly % come from your father. Passing down genes In this family tree, brown hair is dominant to red hair. hair hair Shade in the correct circles to show how the genes have been passed down to the children. Complete the diagram showing the colour of hair the children have. Punnett Squares Let’s represent the previous cross in another way. Fill in the blanks in the Punnett square, to work out what the possible children could look like. Try it again but this time cross Bb x Bb What colour of hair will the parents have? 1. In this family tree tongue rolling is dominant to non-tongue rolling. Represent this cross as a punnett square where T = tongue roller gene and t = non-tongue roller gene. 2. Use the information in your punnett square to shade in the triangles, showing all the possible combinations of children. 3. For the girl born in the family what are the chances she could be tt – i.e. a non-tongue roller? Look at this family tree. How many boys did the couple have? _____________________________________________________ Which gene is dominant? _________________________________________________________ Complete the punnettt square for the above cross.