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____________________________________________ ______________________ Name BIO 447 Immunobiology Exam 1 First Hourly Exam I. 100 Points October 13, 2015 Filename: 44715Xm1.doc (20 pts) ______(Matching) II. (16 Pts) ______447Intro III. (16 Pts) ______ Antigens IV. (16 Pts) ______ Antibody Structure V. (16 Pts) ______ Interaction of Cells and Components of the Immune Response VI. (16 Pts) ______ Videos or Photos Viewed in Class Total : (100 Pts) ______ I. [20 Pts] Complex Matching See page 2 for the 20 questions and 20 possible answers. Each of the numbered items in Column One has a SINGLE BEST matching Lettered Item in Column Two. From Column Two select the LETTER that BEST matches each NUMBERED item in Column One. Enter that Letter in the blank next to the numbered item in Column One. Each item in Column Two can be used only once. If you use an item more than once, it will be marked wrong wherever it appears. You may want to enter tentative numbers in pencil first until you are sure that you have the set of answers that you want. Please print small so no one else can see what you are entering. I. [20 pts] _______Column One___________ p. 2 _______________Column Two_______________________ 1. _______ Gamma globulin A. Antigen-presenting B. Secretory isotype of immunoglobulin; functions in mucosal linings 2. _______ Fc Regions C. Retained immunogenicity but lost pathogenicity 3. _______ Six CDR’s D. Universal recipient E. PMN’s 4. _______ Dendritic Cell F. Stimulates cell division polyclonally and non-specifically 5. _______ IP G. A property of antibodies determined by isotype 6. ______ Mitogen H. Hold CDR’s in the Correct Conformation 7. _______ Adjuvant I. Can cross the placental barrier to produce hemolytic disease of the new-born (HDNB) 8. _______ Serum half-life J. Cannot bind antigen, but can control effector functions K. Route of immune exposure 9. _______ Induced fit L. Can increase immunogenicity of a vaccine 10. _______ IgA M. Conformational change in antibody triggered by antigen binding 11. ______ Myeloid lineage N. Blood serum fraction where most of the antibodies are found O. Based on topological and physico-chemical complementarity 12. _______ Natural Killer P. Can polyclonally activate T-Cells 13. _______ Framework Regions Q. Triggers a systemic cytokine storm R. Close Together in the 3-Dimentional structure of an antibody 14. _______Lymphoid lineage S. Cytotoxic Cells attracted by Fc Region of Antibodies 15. ______ Antigen-Antibody recognition T. B-Cells and T-Cells 16. _______ Neisseria meningitidis endotoxin 17. _______ Louis Pasteur’s chicken cholera culture after prolonged growth 18. _______ Maternal IgG Antibody to Rh Factor 19. _______ AB Blood Group Person 20. _______Super-Antigen p.3 II. (16 pts) 447 Intro A.(4 Pts) The Immune response is divided into two major forms based on the manner of recognition and response to potential pathogens and to deleterious events in the host. What are these two major forms of the Immune response? Specific Adaptive Innate Natural B. (4 Pts) We cited key observations in human history that revealed important properties of immunity. What property of the immune response is illustrated by each of these historic observations? 1, Freedom from plague and surviving the plague Immunity Exists 2. Susceptibility to other diseases even after survival from plague Immunity is Specific 3. Deliberately inducing an infectious disease can provide later protection Immunity has Memory 4. A non-pathogenic variant or altered version of a pathogen can protect against the pathogen Immunogenicity can be separated from Pathogenicity C. (4 Pts) Give 4 Examples of types of deleterious immune response or Immunopathologies . Please give the types of such immune-based pathologies not just example diseases Allergy or Hypersensitivity. React in appropriately against something Autoimmunity . React against self or have a break-down of tolerance Transplantation Rejection. React against a cell or tissue graft that is used for therapy Immune Responses to Infectious Diseases. Failure to respond adequately to a pathogenic challenge Immune Deficiencies and AIDS. Congenital or acquired weakening of immune responses Tumor Immunity: Failure to respond to a cancer challenge or promotion of cancer by the immune response D. (4 Pts) The immune response system is radically different from organs like the heart, liver, and brain in terms of its structural organization and its location. In what ways is the immune response system totally different from any other system in the body except possibly the endocrine system and the nervous system? There are two different features about the immune response that distinguish it from other system in terms of it structural organization. Immune system is everywhere in the body Immune system is discontinuous p. 4 III. (16 Pts) With respect to Antigens, Haptens, and PAMP (Pathogen-associated Molecular Patterns) Antigens and PAMP are targets for cells and/or soluble factors of the immune response and are recognized by different types of membrane receptors. Antigens and PAMP differ profoundly in the types of cells that respond to them as targets. Antigens and PAMP also differ profoundly in the type of immune response that they elicit. A. (4 Pts) . In terms of cells or soluble factors or membrane receptors that respond: (You need to cite only one cell type or one soluble factor or membrane receptor) What responds to antigens? B-Cells or T-Cells or T-Cell Receptors or Antibodies B. (4 Pts) In terms of cells or membrane receptors that respond: (you need to cite only one cell type or one class of membrane receptors) What responds to PAMP? Natural Killer Cells, or Monocytes or Macrophages or PMN’s or Neutrophils or Eosinophils or Basophils or Mast Cells Receptors C. (4 Pts) What type of immune response is elicited in response to antigens in question A above? Specific Adaptive D. (4 Pts) What type of immune response is elicited in response to PAMP in question B above? Innate Natural p. 5 IV. (16 pts) Antibody Structure and Use A.(4 Pts) A single antibody molecule is “bivalent”. What does that mean in terms of antigen-antibody binding? ( 2 Pt) One antibody protein can bind two antigenic determinants or Antibody has two Fab arms A single antibody molecule is divided into two major regions, What are these two major regions? (2 Pts) Fab and Fc B. (4 Pts) What does “CDR” stand for? ( 1 Pt) Complementarity determining region In what region of the antibody molecule are CDR’s located ? (1 Pt) Variable or Fab What do CDR’s do in molecular or immunological terms? Bind antigen or form antigen-binding site C.(4 Pts) Give the abbreviations or names for three different full Immunoglobulin Isotypes IgG, IgM, IgD, IgE, IgA, IgG1, IgG2, IgG3, IgG4 Gamma globulin, macroglobulin D.(4 Pts) What is this graphic showing? Radio-active antibody labeling of metastatic cancers or Monoclonal antibody labeling p. 6 V. (16 Pts). Interaction of Cells and Components of the Immune Response A. (4 Pts) What are each of these two cells doing? The small cell on the left is a lymphocyte. What is the big cell on the right? T-Cell and Macrophage (also accept Dendritic Cell) B. (4 Pt) What is the picture below showing (“Picture 1”) (2 Pts) Clonal Selection Picture 1 Object 1 What is the item marked “Object 1”? (2 Pt) Antigen p. 7 V. Continued. C.(4 Pts) The stem cell shown in B. is making cells 1,2,3, and 4. What else does it have to make when it divides in order to do its job correctly? Replace itself D. ( 4 Pts) 1.What kind of B-cell is the one at the bottom? Plasma Cell or Antibody –secreting cell 2.What is the T-cell in the middle of the picture producing? Cytokines (or IL2) 3. The T-cell on the right is killing a target cell. That means that the T-cell is a special kind of T-cell called a : Cytotoxic T-Cell or Tc This is a special kind of differentiated B-cell called a______ cell. What is this stuff? What kind of T-cell is this? p. 8 VI. (16 Pts) Videos and Photos Shown in Class A. (4 Pts) In “Killer Disease on Campus” we saw the story of the emergency physicians from London’s St. Mary’s Hospital going far outside of London late at night to treat a young woman, Pauline Upton, who was gravely ill with meningococcal sepsis. One emergency care physician looked into her eyes with a light and said “That’s good”! What was he looking for and was relieved to find that it was absent? Brain swelling or Nervous system involvement B. (4 Pts) In meningococcal sepsis the infectious organism is easily killed with penicillin, yet the devastating consequence of the infection can still persist even though the organism is dying. What is causing the persistence of the disease? Endotoxin C.(4 Pts) What is this photo showing? What is the green structure on the left? What are the blue and orange structures on the right? p. 9 D.(4 Pts) What pathology is this little boy exhibiting? Smallpox