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Fermentation Sections 6.13-6.16 6.13 Fermentation • Fermentation is a way of harvesting chemical energy that does not require oxygen. Fermentation – takes advantage of glycolysis, – produces two ATP molecules per glucose, and – reduces NAD+ to NADH. • Fermentation must provide an anaerobic path for recycling NADH back to NAD+. © 2012 Pearson Education, Inc. 6.13 Lactic acid Fermentation • Your muscle cells (when?) and certain bacteria can oxidize NADH through lactic acid fermentation, in which – NADH is oxidized to NAD+ and – pyruvate is reduced to lactate. © 2012 Pearson Education, Inc. Figure 6.13A 2 ADP 2 P 2 ATP Glycolysis Glucose 2 NAD 2 NADH 2 Pyruvate 2 NADH 2 NAD 2 Lactate 6.13 Lactic Acid Fermentation • Lactate is carried by the blood to the liver, where it is converted back to pyruvate and oxidized in the mitochondria of liver cells. • Bacteria: What foods are produced by lactic acid fermentation? © 2012 Pearson Education, Inc. 6.13 Fermentation • Alcohol Fermentation • In this process yeasts (single-celled fungi) – oxidize NADH back to NAD+ and – convert pyruvate to CO2 and ethanol. • What foods are produced by alcohol fermentation? © 2012 Pearson Education, Inc. Figure 6.13B Glucose 2 NAD Glycolysis 2 ADP 2 P 2 ATP 2 NADH 2 Pyruvate 2 NADH 2 CO2 2 NAD 2 Ethanol 6.13 Fermentation • Obligate anaerobes • Facultative anaerobes © 2012 Pearson Education, Inc. 6.14 EVOLUTION CONNECTION: Glycolysis evolved early in the history of life on Earth • The ancient history of glycolysis is supported by its – occurrence in all the domains of life and – Uses pathways that do not involve any membranebounded organelles. © 2012 Pearson Education, Inc. 6.15 Cells use many kinds of organic molecules as fuel for cellular respiration • Although glucose is considered to be the primary source of sugar for respiration and fermentation, ATP is generated using – carbohydrates, – fats, and – proteins. © 2012 Pearson Education, Inc. Figure 6.15 Food, such as peanuts Carbohydrates Sugars Fats Proteins Glycerol Fatty acids Amino acids Amino groups Glucose G3P Pyruvate Glycolysis Pyruvate Oxidation Acetyl CoA ATP Citric Acid Cycle Oxidative Phosphorylation