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Gene Section
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BOP1 (block of proliferation 1)
Audrey Killian, Richard Sesboüé
INSERM U614, Faculté de Médecine-Pharmacie de Rouen, 22 boulevard Gambetta, 76183 ROUEN Cedex 1, France
(AK, RS)
Published in Atlas Database: October 2008
Online updated version : http://AtlasGeneticsOncology.org/Genes/BOP1ID44348ch8q22.html
DOI: 10.4267/2042/44551
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2009 Atlas of Genetics and Cytogenetics in Oncology and Haematology
DGAT1, 8q24.3, diacylglycerol O-acyltransferase
homolog 1 (mouse); FBXL6, 8q24.3, F-box and
leucine-rich repeat protein 6; GPR172A, 8q24.3, G
protein-coupled receptor 172A; ADCK5, 8q24.3, aarF
domain containing kinase 5; CPSF1, 8q24.3, cleavage
and polyadenylation specific factor 1, 160kDa;
SLC39A4, 8q24.3, solute carrier family 39 (zinc
transporter), member 4.
Note: The BOP1 gene is a member of the nucleolar
PeBoW-complex (PES1, BOP1, WDR12) essential for
cell proliferation and maturation of the large ribosomal
subunit.
On the basis of experiments performed in yeast, this
complex is likely to involve other proteins: GRWD1,
RPL3, and ORC6L.
A better designation, found in some databases, should
be: ribosome biogenesis protein BOP1.
Identity
Other names: KIAA0124
HGNC (Hugo): BOP1
Location: 8q24.3
Local order: According to the NCBI map viewer,
genes flanking BOP1, in centromere to telomere
direction on 8q24.3, are:
GPAA1, 8q24.3, glycosylphosphatidylinositol anchor
attachment protein 1 homolog (yeast); CYC1, 8q24.3,
cytochrome c-1; SHARPIN, 8q24.3, SHANKassociated RH domain interactor; MAF1, 8q24.3,
MAF1 homolog (S. cerevisiae); KIAA1875, 8q24.3;
C8orf30A, 8q24.3, chromosome 8 open reading frame
30A; KIAA1833, 8q24.3, hypothetical protein
KIAA1833; BOP1, 8q24.3, block of proliferation 1;
HSF1, 8q24.3, heat shock transcription factor 1;
Fig1 A: Genomic structure of BOP1: the gene extends over 29kb with 16 exons (lower part). Exons 4-16 (upper part)
are clustered in 2.6 kb while exons 1-3 are separated by large (2-12 kb) introns.
Atlas Genet Cytogenet Oncol Haematol. 2009; 13(9)
622
BOP1 (block of proliferation 1)
Killian A, Sesboüé R
Fig1 B.
Fig2. Position of the WD repeats.
DNA/RNA
Implicated in
Description
Colorectal cancer
The BOP1 gene is situated 16.6 Mb downstream from
the MYC proto-oncogene (8q24.21) and 0.8 Mb
upstream from the telomere (Fig1B).
No pseudogene has been reported for BOP1, but the
NCBI Map viewer (Build 36.3) displays a perfect
match encompassing exons 4-16, 64kb centromeric to
the gene.
Note
A copy number increase of the BOP1 gene was
detected in 39% of colorectal cancer samples (n=56)
and was associated with an increase of its mRNA level.
This copy number increase was more frequent than that
observed for MYC, a proto-oncogene located 16.6 Mb
upstream from BOP1 and was distinct from MYC
amplification in 16% of the cases.
Transient overexpression of BOP1 in human cells
increased the percentage of abnormal mitoses with
multipolar spindles.
Protein
References
Transcription
BOP1 mRNA (NM_015201) has a size of 2422 bp.
Pseudogene
Killian A, Le Meur N, Sesboüé R, Bourguignon J, et al.
Inactivation of the RRB1-Pescadillo pathway involved in
ribosome biogenesis induces chromosomal instability.
Oncogene. 2004 Nov 11;23(53):8597-602
Description
The Ribosome biogenesis protein BOP1 consists of 746
amino acids and has a molecular weight of 83.63 kDa.
It contains 7 WD repeats.
Hölzel M, Rohrmoser M, Schlee M, Grimm T, et al. Mammalian
WDR12 is a novel member of the Pes1-Bop1 complex and is
required for ribosome biogenesis and cell proliferation. J Cell
Biol. 2005 Aug 1;170(3):367-78
Expression
BOP1 is expressed ubiquitously and found in nearly all
tissues at similar levels.
Grimm T, Hölzel M, Rohrmoser M, Harasim T, et al. Dominantnegative Pes1 mutants inhibit ribosomal RNA processing and
cell proliferation via incorporation into the PeBoW-complex.
Nucleic Acids Res. 2006;34(10):3030-43
Localisation
Nucleus, nucleolus.
Killian A, Sarafan-Vasseur N, Sesboüé R, Le Pessot F,
Blanchard F, Lamy A, Laurent M, Flaman JM, Frébourg T.
Contribution of the BOP1 gene, located on 8q24, to colorectal
tumorigenesis.
Genes
Chromosomes
Cancer.
2006
Sep;45(9):874-81
Function
Required for maturation of the 25S and 5.8S ribosomal
RNAs. Essential for cell proliferation. Involved in
chromosomal segregation.
Rohrmoser M, Hölzel M, Grimm T, Malamoussi A, et al.
Interdependence of Pes1, Bop1, and WDR12 controls
nucleolar localization and assembly of the PeBoW complex
required for maturation of the 60S ribosomal subunit. Mol Cell
Biol. 2007 May;27(10):3682-94
Homology
Mus musculus Bop1; Rattus norvegicus Bop1; Equus
caballus BOP1; Bos taurus BOP1.
Mutations
This article should be referenced as such:
Killian A, Sesboüé R. BOP1 (block of proliferation 1). Atlas
Genet Cytogenet Oncol Haematol. 2009; 13(9):622-623.
Note
None described to date.
Atlas Genet Cytogenet Oncol Haematol. 2009; 13(9)
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