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Transcript
Lecture 6 The Cell Cycle G0 RESTRICTION POINT G0 Rb P Rb G1 represses gene expression P Rb P relieves repression Rb R growth factor S G1 P Rb P R activate expression of cyclin D activate cdk4 P Rb activate cdk2 activate expression of cyclin E S G2 cyclin A cdk2 M cyclin B cdk1 Cancer • uncontrolled cell division • genetic damage • not corectable • specific damage to genes that regulate cell division GF GF P P P P activation of cyclin D expression cell division Mitosis and Cytokinesis • mitosis: division of the nucleus and its chromosomes • cytokinesis: division of the cytoplasm • RESULT: one cell divides into 2 daughter cells Phases of Mitosis • • • • • Prophase Prometaphase Metaphase Anaphase Telophase During S phase
