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Transcript
CH 17 – RBC Morphology Erythrocytes >99% of the formed elements function to carry O2, CO2 & H+ anatomy biconcave disks, 8 µm in diameter no nucleus limited metabolic activity ~280 million hemoglobin (Hgb) molecules/cell O2 carrying protein synthesized in cytosol before the nucleus is lost 33% of cell weight Erythrocytes Bi-Concave disc shape creates a higher surface area/volume ratio increases gas diffusion very flexible structure allows passage through capillaries the smallest capillaries are no wider than an RBC Erythrocytes Normal Hgb in blood Infants: 14-20g Hgb/100ml Adults: Males: 14-15g Hgb /100ml Females: 12-15g Hgb /100 ml RBC’s (Electron Microscopy) electron microscopy Hemoglobin Structure O2 combines with Hgb in lungs O2 not very soluble in H2O O2 needs a molecular transporter to carry it Hemoglobin 4 globin (protein) chains - 2 α chains & 2 β chains 4 non-protein heme pigments (lipid) each heme pigment has iron ion (Fe²+) that carries 1 O2 each RBC can carry about 1 billion O2 molecules RBC's carry ~25% of the CO2 bound to Hgb - forms carbaminohemoglobin Erythrocyte (RBC) Life Span Life span only 100-120 days cannot repair damage due to loss of nucleus, ribosomes Old RBC’s destroyed in the spleen, liver and the bone marrow Macrophages phagocytize old worn RBC's Breakdown products are recycled Different pathways exist for each part of the Hgb molecule globin chains - AA's used for other protein synthesis heme • • iron portion - Fe2+ recycled non-iron lipid portion – converted to bilirubin - waste – released into blood, secreted by the liver into bile – bile enters intestine, is converted to urobilinogen by bacteria – contributes to urine & feces color RBC Life Span End RBC Morphology CH 17