* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Fragile Sites and Cancer Powerpoint
Genetic engineering wikipedia , lookup
Copy-number variation wikipedia , lookup
Epigenetics of diabetes Type 2 wikipedia , lookup
Nutriepigenomics wikipedia , lookup
Gene expression profiling wikipedia , lookup
Epigenetics of human development wikipedia , lookup
Point mutation wikipedia , lookup
Cancer epigenetics wikipedia , lookup
Neuronal ceroid lipofuscinosis wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Skewed X-inactivation wikipedia , lookup
Gene therapy of the human retina wikipedia , lookup
Gene desert wikipedia , lookup
Y chromosome wikipedia , lookup
Helitron (biology) wikipedia , lookup
Gene therapy wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Saethre–Chotzen syndrome wikipedia , lookup
Polycomb Group Proteins and Cancer wikipedia , lookup
Gene expression programming wikipedia , lookup
Gene nomenclature wikipedia , lookup
Oncogenomics wikipedia , lookup
Neocentromere wikipedia , lookup
Microevolution wikipedia , lookup
Designer baby wikipedia , lookup
Genome (book) wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
The Link Between Fragile Sites and Cancer Susan Chabot 2015-2016 Honors Genetics Unstable Chromosome Regions/ Fragile Sites • First identified in 1970. • Staining of metaphase chromosomes, one area failed to stain giving the appearance of a gap. • Gaps were susceptible to chromosome breakage. • Cause of fragility is unknown. • 120 fragile sites have been identified to date. • Considered part of normal chromosome structure and present in nearly all individuals. FHIT Gene • FHIT gene (fragile histidine triad) located within FRA3B on p arm of chromosome 3. • FHIT gene acts in tumor suppressor function. • The normal protein product of this gene is absent in cells of many cancers • Lung • Esophagus • Breast • Cervical • Liver • Kidney • Pancreas • Colon • Stomach WWOX Gene • Acts as a tumor suppressor gene, provides surveillance by recognizing cancer cells and causing apoptosis. • Located in FRA16D site on chromosome 16. • Implicated in a range of human cancers/Found to be lost or silenced in variety of cancers: • Lung, breast, ovary, prostate, bladder, esophagus, pancreas • If gene is present, it is heavily methylated and inactive. Inducers and Enhancers of Fragile Sites