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I. Genetics A. Gregor Mendel 1. Known as the father of genetics. 2. Worked with garden peas. 3. Led to knowledge of inheritance. 4. Heredity – transmission of traits from parents to the offspring. B. Gene – the basic unit of inheritance. 1. Made of DNA. 2. In sexual reproduction: a) One gene from the male parent. b) One gene from the female parent. c) Why you have two copies of same chromosome. 1 3. Alleles – alternate forms of a gene. a)Ex: seed color (yellow, green seed) C. Dominant and Recessive alleles 1. Dominant alleles – an allele that masks the presence of another allele. a)Always use capital letters. 2. Recessive alleles – an allele that is being masked by the dominant allele. a)Always use lower-case letters. 3. Homozygous – when both alleles are the same (homo = same). a)Homozygous Dominant (AA) or homozygous recessive (aa) 4. Heterozygous – when both alleles are NOT the same (Hetero = different) a)Heterozygous dominant (Aa) 2 5. Genotype – genetic makeup of an organism. a) Ex: AA, Aa, aa b) Geno = genes, genetics 6. Phenotype – physical appearance of an organism. a) Ex: tall, yellow, wrinkled b) Pheno = physical II. Mendel’s work A. Three Principles: 1. Principle of dominance – an allele masks another allele. 2. Principle of Segregation – two alleles for a characteristics separate during gamete formation. 3 3. Principle of Independent Assortment – alleles for different characteristics (genes) are distributed to gametes independently. III. Punnett Squares – used to describe the ratio of expected outcomes of a genetic cross. A. Monohybrid cross – (mono meaning one) 1 trait is crossed. 1. Have two alleles for each gene. 2. Ex: T = tall, dom t = short TT x tt (parents) 4 3. More ex: TT x Tt Tt x Tt 4. Testcross – an individual with unknown genotype is crossed with a homozygous recessive individual. a)Ex: rabbit color B = black, dom b = brown BB x bb Bb x bb • If any brown rabbits then the parents were heterozygous, if not then they were homozygous. 5 5. Incomplete dominance – when one allele does not completely mask another. a)The organism shows a blend of the two. b)Ex: Japanese 4 o’clocks R = red W = white RR x WW RW = pink 6. Codominance – when both alleles contribute to the phenotype of the organism (no blending). a)Ex: cattle color R = red r = white RR x Rr Rr = roan 7. Polygenic traits – traits controlled by two or more genes. (poly = many) 6 8. Sex-linked traits – trait occurs only on a sex chromosome. a)Ex: colorblindness XX = female B = normal, dom XY = male b = colorblindness XBXB = normal female XBXb = normal female, carrier XbXb = colorblind female XBY = normal male XbY = colorblind male XBXb x XBY 7 9. Blood types: a)A blood = IAIA or IAi b)B blood = IBIB or IBi c)AB blood = IAIB d)O blood = ii B. Dihybrid Crosses – two genes are crossed at the same time. 1. Ex: seed color and texture P = purple kernel, dom P = yellow kernel, rec S = smooth, dom S = wrinkled PpSs x PpSs (remember Foil – for all possible combinations of gametes) 8