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Potato Genome Project 1.Structural Genomics Generation of a comprehensive genomic resource of Solanaceae resistance (R) gene sequences of wild potato, tomato and pepper genomes (the SOLAR database) 2.Functional Genomics Generation of a comprehensive functional genomic resource composed of expression profiles of significant points in growth, development and response to abiotic and biotic stresses, and a set of functionally defined genes identified through virus-induced gene silencing to be involved in host response to pathogens 3.Outreach A training program for high school and college students to teach applications of bioinformatics and data mining for marker development for potato breeding for crop improvement Synteny between Solanaceae Genomes 1 2 3 4 5 6 7 8 9 10 11 12 The Solanaceae share highly conserved genomes Potato Chromosome number and organization Genome sequence 1 2 3 4 5 6 7 8 9 10 11 12 Pepper Sequence and function of gene location and resistance hotspot location 1 2 3 4 5 6 7 8 9 10 11 12 Tomato Resistance hotspots Chromosome 5 Resistance Region Potato Tomato GP21 GP179 GP179 R1, phyt3, Pi1,Nb, Rx2, Gpa, Grp GP21 Bs4 S. demissum is an allo-hexaploid Chromosome #5 5A R1, phyt3, Pi1,Nb, Rx2, Gpa, Grp 5B 5C S.demissum Chromosome 5 Resistance Region 8~12 BACs per genome ~0.5Mb per genome A GP179 R1 SPUD237 GP179 132D05 132D05S GP21 Haplotype Sd_Bs4 R1, phyt3, Pi1, Nb, Rx2, Gpa, Grp GP179 GP21 132D05 Chromosome #5 R1 Sd_Pr f Sd_Pr f B Sd_Bs4 C Sd_Prf S.demissum Chromosome 11 Resistance Region Potato Pepper RMcl, Ry, Na, Sen1, R3a, R3b, R5, R6, R7, R8, R9, R10, phyt7 Tomato phyt3 I I2 L, cmv1, phyt3 S. demissum is hexaploid Chromosome #11 11A RMcl, Ry, Na, Sen1, N R3a, R3b, R5, R6, R7, R8, R9, R10, phyt7 11B 11C S.demissum Chromosome 11 Resistance Region Haplotype A B 56F6R 193I9R Chromosome #11 39E18F RMcl, Ry, Na, Sen1, S.demissum Chromosome 11 Resistance Region Haplotype A B C 373T 373T 381T TG105 381T 11~16 BACs 1.5Mb 373T 381T Chromosome #11 51S R3a, R3b, R5, R6, R7, R8, R9, R10, phyt7 S.demissum Chromosome 11 Resistance Region R3a, R3b, R5, R6, R7, R8, R9, R10, phyt7 Haplotype A B C 51S 51S 51S 373T GP185 373T 12~16 BACs ~1.5Mb 373T 381T Chromosome #11 Distance tree for all I2/R3 homologues from the MLB locus 6 5 1 4 3 0.1 substitution/site 2 GP185 region GP250 region