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Genetic Engineering Noadswood Science, 2011 Tuesday, May 23, 2017 Genetic Engineering To understand the process of genetic modification Anagrams Solve the anagrams: Lodyl Dolly Senge Genes Uclesun Nucleus Niclngo Cloning Srgrueoat Surrogate Slxaeua Asexual Tinctug Cutting Mborye Embryo Loenc Clone Ohmemcrosos Chromosomes Genetic Engineering Genetic engineering is also called genetic modification or GM and is very different from cloning What differences are there? Cloning Genetic Engineering Produces exact copies Produces a unique set of genes Genes copied within the same species Genes can be swapped across species Genetic Engineering How have humans changed the genetic make-up of organisms that we have taken advantage of ? Selective breeding - only breeding the organisms with the characteristics we wanted Genetic engineering takes genes from one organism, and places them into the chromosomes of another organism… Genetic Engineering Genetic engineering takes genes from one organism, and places them into the chromosomes of another organism. It alters an organism's genetic code, and works because there is only one code for life The set of instructions for which a gene is responsible work whichever organism the gene is in, e.g. a gene for luminescence from a jellyfish can be added to a frog, making it luminescent too! Method Enzymes are used to cut up and join together parts of the DNA of one organism, and insert them into the DNA of another organism In the resulting new organism the inserted genes will code for one or more new characteristics - for example producing a new substance, or performing a new function The organism has been genetically re-engineered E.g. a bacterium's genetic makeup can modified by splicing a gene into its DNA Method – Detailed Certain enzymes can cut pieces of DNA from one organism, and join them into a gap in the DNA of another organism The new organism with the inserted genes has the genetic information for one or more new characteristics, e.g. the organism might produce a useful substance, or be able to carry out a new function The method can be used to produce bacteria that produce insulin (valuable hormone needed for people with diabetes) – bacteria are used as they reproduce very quickly rather than having to extract the insulin from other humans / animals Insulin Production Arguments There are strong arguments for and against cloning and genetic engineering It is possible to produce genetically modified animals and plants – sheep that produce human proteins for treating the symptoms of cystic fibrosis (a disease which causes sufferers to produce abnormally thick and sticky mucus in their lungs) have been produced, and even tobacco plants that glow in the dark when they need watering Some people are excited by the almost limitless possibilities of cloning and genetic engineering, while some people believe the process is unethical and should be banned. Others are concerned about what might happen in the future as these techniques are all relatively new… Pros & Cons Complete the genetic engineering pros & cons worksheet Pros & Cons Pros Cons Could be used to reduce the impact of genetic disease ‘Playing God’ Can be used to treat diseases (cut out genes) It might not work (genes are complicated!) and you would waste money Plants growth rate could be improved therefore saving money and providing more food Genes could spread into the wildlife in other places or often the plants aren’t fertile so seed would need to be bought every year It may be possible to genetically engineer animals to harvest human organs Designer babies is a concern for many people GM foods could have a longer shelf life The effects aren’t yet known long term concerns include pesticide resistant insects Animals such as cattle can be made to grow faster Reducing the ‘gene pool’ Fruit and vegetable ripening rate can be changed You could modify food so it grows in any conditions, helping hunger problems Debate Where do you stand with genetic engineering? You have five minutes to consider your standpoint, and then we shall open up a debate (remember during the debate you do not interrupt! If there is something you disagree with you must remain silent, just raise your hand for your viewpoints to be heard! Viewpoints When arguing about GM consider the following In favour: - Cloning company director A mother wanting to clone an organ for her son A scientist involved in reproductive and therapeutic cloning A scientist only involved in therapeutic cloning A government minister Against : A scientist involved in the project with cloned Dolly the sheep A government minister A women’s rights activist Head of the Christian church