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Chapter 12 (part 1) Citric Acid Cycle Gylcolysis Electron Transport and Oxidative phosphorylation TCA Cycle Entry into the TCA Cycle Pyruvate Dehydrogenase Citrate Synthase • Only step in TCA cycle that involves the formation of a C-C bond Aconitase Isocitrate Dehydrogenase -Ketoglutarate Dehydrogenase Succinyl-CoA Synthetase Fumarase Malate Dehydrogenase Reduced Coenzymes Fuel ATP Production • Acetyl-CoA + 3 NAD+ + Q + GDP + Pi +2 H20 HS-CoA + 3NADH + QH2 + GTP + 2 CO2 + 2 H+ • • • • • Isocitrate Dehydrogenase -ketoglutarate dehydrogenase Succinyl-CoA synthetase Sunccinate dehydrogenase Malate Dehydrogenase 1 NADH=2.5 ATP 1 NADH=2.5 ATP 1 GTP=1 ATP 1 QH2=1.5 ATP 1 NADH=2.5 ATP • Total of 10 ATPs gained from oxidation of 1 AcetylCoA Regulation of TCA Cycle Protein/amino acid Catabolites feed Into the TCA Cycle Fats breakdown and feed into the TCA Cycle TCA Cycle provides intermediates for many biosynthetic processes The Anaplerotic Reactions The "filling up" reactions • PEP carboxylase - converts PEP to oxaloacetate • Pyruvate carboxylase - converts pyruvate to oxaloacetate • Malic enzyme converts pyruvate into malate Following the carbons through the TCA cycle