Download post- translational modifications

PTM
We are pleased to present a selection of our building blocks
for the synthesis of PTM peptides and proteins.
Post-translational modifications (PTMs) enable the cell
to change the properties and activities of proteins after
expression. Most of the PTMs are catalyzed by specialized
enzymes. Practically all proteinogenic amino acids can be
modified, thus PTMs considerably increase the diversity
of protein structures. PTMs generate or eliminate charged
moieties and thus changes the pI of a protein, e.g. by Ophosphorylation or Nε-acetylation of Lys. N-Acetylation
and N-methylation of histones are tools for regulating DNA
transcription, they can be reverted. Non-enzymatic PTMs
can be an indication of “aging” of proteins or pathological
processes.
For our complete range of peptides, amino acid derivatives,
and biochemicals please visit shop.bachem.com
ACETYLATION
POSTTRANSLATIONAL
MODIFICATIONS
Boc-Hyp-OH
A-1790
Boc-Hyp(Bzl)-OH
A-2820
METHYLATION
Fmoc-Arg(Me)(Pbf)-OH
Fmoc-Arg(Me)₂-OH (asymmetrical)
hydrochloride salt
Fmoc-Arg(Me)₂-OH (symmetrical)
hydrochloride salt
Fmoc-Lys(Boc)(Me)-OH
Fmoc-Lys(Me)₂-OH · HCl
Fmoc-Lys(Me)₃-OH chloride
B-4010
Fmoc-His(1-Me)-OH
Fmoc-His(3-Me)-OH
Boc-His(1-Me)-OH
Boc-His(3-Me)-OH
B-3375
B-3365
A-2560
A-2565
B-2745
B-3345
B-3575
B-3290
B-2685
Fmoc-Lys(Ac)-OH
B-3520
PHOSPHORYLATION
Boc-Lys(Ac)-OH
A-1050
Fmoc-Ser(PO(OBzl)OH)-OH
B-3455
Fmoc-Ser(PO₃H₂)-OH
B-2505
Fmoc-Thr(PO(OBzl)OH)-OH
B-3460
Fmoc-Thr(PO₃H₂)-OH
B-3425
Fmoc-Tyr(PO(OBzl)OH)-OH
B-3565
Fmoc-Tyr(PO₃Me₂)-OH
B-1990
Fmoc-Tyr(PO₃(MDPSE)₂)-OH
B-2910
Fmoc-Tyr(PO₃H₂)-OH
B-2470
Boc-Tyr(PO₃Me₂)-OH
B-3595
CARBOXYLATION
Fmoc-γ-carboxy-Glu(OtBu)₂-OH
B-1265
Z-γ-carboxy-Glu(OtBu)₂-OH
C-1510
GLYCOSYLATION
Fmoc-Asn(GlcNAc(Ac)₃-β-D)-OH
B-2480
Fmoc-Ser(GlcNAc(Ac)₃-β-D)-OH
B-3865
Fmoc-Thr(GlcNAc(Ac)₃-β-D)-OH
B-4245
Fmoc-Ser(GalNAc(Ac)₃-α-D)-OH
B-2565
Fmoc-Ser(GalNAc(Ac)₃-β-D)-OH
B-4235
SULFATION
Fmoc-Thr(GalNAc(Ac)₃-α-D)-OH
B-2570
Fmoc-Tyr(SO₂(ONeopentyl))-OH
B-4230
Fmoc-Thr(GalNAc(Ac)₃-β-D)-OH
B-4240
Fmoc-Tyr(SO₃H)-OH sodium salt B-2765
HYDROXYLATION
Fmoc-Hyp-OH
B-2800
Fmoc-Hyp(tBu)-OH
B-1525
C.Kannicht (ed), Post-Translational Modification of Proteins, Humana
Press, Totowa NJ 2002
C. T. Walsh, Posttranslational Modification of Proteins: Expanding
Nature’s Inventory, Roberts and Co., Englewood CO 2005
Custom Synthesis at Bachem

Quality
• GMP and non-GMP quality
• Broad range of impurities and related products
• State-of-the-art analytical capabilities
• Industry leader

Chemistry
• Fmoc-, Boc-, Z- and other synthetic strategies
• Native chemical ligation
• Synthesis of complex peptides

Capacity
• Production sites in the USA and Europe
• Largest production facilities in the market
• Up-to-date technology

Modifications
• Acylation, acetylation, amidation, PEGylation, glycosylation etc.
• Cyclizations
• Stabilizing modifications

Support
• Highly qualified technical support team
• Documentation
• Confidentiality
Marketing & Sales Contact
Europe, Africa, Middle East and Asia Pacific
Bachem AG
Tel. +41 58 595 2020
[email protected]
Americas
Bachem Americas, Inc.
Tel. +1 888 422 2436 (toll-free in USA & Canada)
+1 310 539 4171
[email protected]
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Published byPublished
Global Marketing,
Group,February
2016
by GlobalBachem
Marketing,
Bachem Group,
February 2015
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