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Transcript
Ribosomes PETE MCGEE What are Ribosomes? Found in every cell Protein Synthesizers of the cell Located on the Rough ER and in the cytoplasm in eukaryotic cells and move freely in prokaryotic cells They are a combination of RNA and proteins What do they do? Read mRNA (messenger RNA) to build proteins Rough ER Builds proteins to send out of the cell Cytoplasm Builds proteins to use in the cytoplasm What do they look like? They are up to 10x’s larger in Eukaryotic cells 2 Subunits-based on sedimentation in a centrifuge Smaller one attaches to mRNA Larger attaches to tRNA (transfer RNA) and amino acids What happens when they don’t work correctly Alzheimer's Disease Impairment of the function of ribosomes Decreased rate of protein synthesis and ribosomal RNA and tRNA Ultimately results in memory loss Diamond-Blackfan anaemia Extremely rare Low blood cell count Occurs when ribosomal protein 19 is mutated and affects the translation and protein synthesis in the bone marrow Ultimately results in lack of oxygen to the body
