Download Slide ()

NMDA receptor-dependent LTP and LTD. LTP refers to a prolonged (hours to days) increase in the size of a postsynaptic response to a presynaptic
stimulus of given strength. Activation of NMDA receptors is obligatory for the induction of LTP that occurs in the hippocampus. NMDA receptors normally
are blocked by Mg2+ at resting membrane potentials. Thus, activation of NMDA receptors requires glutamate binding and the simultaneous depolarization
of the postsynaptic membrane. This is achieved by activation of AMPA/kainate receptors at nearby synapses involving inputs from different neurons.
AMPA receptors also are dynamically regulated to affect their sensitivity to the synergism with NMDA. Thus, NMDA receptors may function as coincidence
detectors, being activated only when there is simultaneous firing of 2 or more neurons. LTD is the converse of LTP. A. NMDA receptor-dependent LTP
Source: Neurotransmission and the Central Nervous System, Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
requires post synaptic NMDA receptor activation leading to a rise in Ca2+ and activation of CaM kinase II (CaMKII). AMPA receptor insertion into the
Hilal-Dandan
R, mechanism
Brunton LL. Goodman
Gilman's
Manual
Pharmacology
and Therapeutics,
2016 Available
at:entry through
postsynaptic Citation:
membrane
is a major
underlyingand
LTP
expression.
B. ofNMDA
receptor-dependent
LTD is2e;
triggered
by Ca2+
http://mhmedical.com/
Accessed:
April
29,
2017
postsynaptic NMDA receptor channels, leading to increases in the activity of the protein phosphatases calcineurin and PP1. LTD occurs when
© 2017 are
McGraw-Hill
Education.
All with
rights
reserved from Nestler EJ, Hyman SE, Malenka RC, eds. Molecular Neuropharmacology.
postsynaptic Copyright
AMPA receptors
internalized.
(Redrawn
permission
New York: McGraw-Hill, 2009, p 132. © 2009 by The McGraw-Hill Companies, Inc.)