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Advanced Bio (Bio 121) Fall 2005 Marion Jr. Sr. High School D. Wise Course Description Basic principles of the scientific method, biochemistry, cellular metabolism, cell structure and function, photosynthesis, respiration, and genetics. Completion of this course will result in 4 hours of college credit through FLCC. Course Objective Students will develop and understanding of the basic principles of biology. A major objective of the course is to develop skills relating to the process of conducting science and the scientific method. Students will develop and understanding of the basic principles of biochemistry, cell structure and function, cell metabolism (photosynthesis and respiration), and genetics. Students are expected to be able to apply concepts to solve problems. Instructor Contact Info David Wise—Rm. 57 Email: [email protected] Textbook Audesirk, Teresa and Audesirk, Gerald, Biology: Life on Earth, 7th ed., Prentice Hall, 2004 Grading Grades are determined by a total points system. Class exams ~100 pts each (4) Laboratory exam ~100 pts Homework and quizzes ~10-20 pts each Laboratory reports 25 pts each Final Exam 10 % Grade conversion scale with grade point equivalents. A AB+ B BC+ 93 & above 90-92 87-89 84-86 83-81 78-80 4.0 3.7 3.3 3.0 2.7 2.3 C CD+ D DF 75-77 72-74 69-71 66-68 63-65 62 & lower 2.0 1.7 1.3 1.0 0.7 Schedule of Topics A. Introduction 1. Biology as a science 2. Characteristics of life 3. Scientific method B. Basic 1. 2. 3. 4. 5. Chemistry Atomic structure Chemical bonds Chemistry of Water Organic functional groups Carbohydrates: structure and function in living organisms 6. Lipids: structure and function in living organisms 7. Proteins: structure and function in living organisms 8. Nucleic acids: structure and function in living organisms C. Principles of metabolism 1. Energy 2. Thermodynamics 3. Endergonic and exergonic reactions 4. Enzymes CLASS EXAM #1 (Audesirk Ch 1-3) D. Cell membrane structure and function 1. Membrane Structure 2. Passive transport mechanisms a. Diffusion b. Osmosis (tonicity, plasmolysis) c. Facilitated diffusion 3. Active Transport Mechanisms a. Active Transport b. Bulk transport (endocytosis, exocytosis) E. Cell structure and Function 1. Cell theory 2. Prokaryotic vs. eukaryotic cells 3. Eukaryotic cell organelles 4. Animal vs. plant cells 5. Specialized plant cell structures CLASS EXAM #2 (Audesirk Ch 4-6) F. Photosynthesis 1. Thermodynamics, energy and ATP 2. Cyclic vs. noncyclic photophosphorylation 3. Light dependent reactions a. High energy electrons b. Electron acceptors and transport systems c. Formation of NADPH2 d. O2 formation from H20 4. Light independent reactions a. Carbohydrate synthesis b. CO2 formation and the role of PGAL 5. C3 vs. C4 pathway G. Respiration 1. Thermodynamics, energy and ATP 2. Glycolysis and pyruvate formation 3. Anaerobic respiration a. Lactic acid formation b. Alcohol fermentation 4. Aerobic respiration a. Krebs cycle b. Electron transport system c. Terminal oxidation and the role of oxygen CLASS EXAM #3 (Audesirk Ch 7&8) H. DNA 1. Molecular structure 2. DNA replication 3. Gene expression a. The genetic code b. Role of RNA in gene expression (rRNA, mRNA, tRNA) c. Transcription d. Translation e. Post-transcriptional and post-translational modifications f. DNA mutations and protein function I. Cell reproduction 1. Prokaryotic cell division 2. Chromosome structure 3. Eukaryotic cell cycle 4. Mitosis and cytokinesis 5. Meiosis J. Genetics and Inheritance 1. Monohybrid cross 2. Dihybrid cross 3. Independent assortment 4. Sex-linked genes 5. Incomplete dominance and codominance 6. Genetic disorders 7. Genetic problem solving CLASS EXAM #4 (Audesirk Ch 9-12) K. Biotechnology 1. Recombinant DNA 2. Methods in biotechnology 3. Human gene therapy 4. Ethical considerations FINAL EXAM--COMPREHENSIVE