Download How tDCS polarizes a highly folded cortex

HowtDCSpolarizesa
highlyfoldedcortex
MaromBikson
LucasParra,AsifRahman,NiranjanKhadka,JacekDmochowski,
DorisLing,MarkJackson,DennisTruong,BelenLafon,Gregory
Kronberg,OleSeibt,DevinAdair,NigelGebodh,ThomasRadman
Disclosure:
SoterixMedicalInc.producestDCSandHigh-DefiniPon
tDCS.MaromBiksonisfounderandhassharesinSoterix
Medical.MaromBiksonservesonthescienPficadvisory
boardofBostonScienPficInc.
Support:
NIH(NINDS,NCI,NIBIB),NSF,AndyGroveFoundaPon,
EpilepsyFoundaPon,WallaceCoulterFoundaPon,DoD
(USAF,AFOSR)
SlidesatNeuralEngr.com
ConcentricspheremodelsoftDCS
Rush&Driscoll(1968)Current
distribuPoninthebrainfrom
surfaceelectrodes
AnalyBcalSoluBon
ConcentricspheremodelsoftDCS
Rush&Driscoll(1968)Current
distribuPoninthebrainfrom
surfaceelectrodes
AnalyBcalSoluBon
Mirandaetal.(2006)Modeling
thecurrentdistribuPonduring
transcranialdirectcurrent
FiniteElementMethod
Da^aetal.(2008):TranscranialcurrentsPmulaPonfocality
usingdiscandringelectrodeconfiguraPons:FEManalysis.
MontageopBmizaBon
Dmochowskietal.(2012):ThepointspreadfuncPonofthe
humanhead-implicaPonsfortranscranialcurrentsPmulaPon.
neuralengr.com/spheres
ConcentricspheremodelsoftDCS
Rush&Driscoll(1968)Current
distribuPoninthebrainfrom
surfaceelectrodes
AnalyBcalSoluBon
Mirandaetal.(2006)Modeling
thecurrentdistribuPonduring
transcranialdirectcurrent
FiniteElementMethod
Da^aetal.(2008):TranscranialcurrentsPmulaPonfocality
usingdiscandringelectrodeconfiguraPons:FEManalysis.
MontageopBmizaBon
Dmochowskietal.(2012):ThepointspreadfuncPonofthe
humanhead-implicaPonsfortranscranialcurrentsPmulaPon.
neuralengr.com/spheres
Da^aetal.(2008)
Cathode
Anode
•  Completecurrentpathfrom
AnodetoCathode
Cathode
Anode
•  Completecurrentpathfrom
AnodetoCathode
•  InwardunderAnode,Outward
underCathode
Cathode
Anode
•  Completecurrentpathfrom
AnodetoCathode
•  InwardunderAnode,Outward
underCathode
•  TangenPalbetweenelectrodes
•  Asymmetricpyramidal
neuronsincorPcalcolumns
•  DirecPonalcurrentflow
relevanttocorPcalsurface
(columnsandpyramidal
neurons)
•  Polarityspecificpyramidal
polarizaPonwithradialcurrent
•  Atanypolarity:Nosuchthing
asa“depolarizing”tDCS
Biksonetal.(2004)EffectsofuniformextracellularDCelectricfieldson
excitabilityinrathippocampalslicesinvitro.JournalofPhysiology.2004
•  TangenPalcurrentflow
polarizesafferentaxons
•  NeuromodulaPonatall
direcPonsofcurrentflow
Rahmanetal.(2004)CellularEffectsofAcuteDirectCurrentSPmulaPon:
SomaPcandSynapPcTerminalEffects.JournalofPhysiology.2013
Da^aetal.(2008)
Da^aetal.(2008)
M1-SOPads
4x1HD
Da^aetal.(2008)FocaltDCSusingconcentricringelectrodeconfiguraPons.
3rdInternaPonalConferenceonTMS/tDCSconference
Da^aetal.(2009)Gyri–preciseheadmodeloftranscranialDCsPmulaPon:
ImprovedspaPalfocalityusingaringelectrode.BrainSPmulaPon
M1-SOPads
•  Currentbetweenandaroundelectrodes
•  ClusteringofintensitybasedofidiosyncraPcanatomy
•  Peakbetweenelectrodes
Da^aetal.(2008)FocaltDCSusingconcentricringelectrodeconfiguraPons.
3rdInternaPonalConferenceonTMS/tDCSconference
Da^aetal.(2009)Gyri–preciseheadmodeloftranscranialDCsPmulaPon:
ImprovedspaPalfocalityusingaringelectrode.BrainSPmulaPon
•  MajorityofcurrenttangenPal
•  DirecPonalityinversionwithinGyri(underelectrode)
Howcanpolarityspecific(orany)
effectsresultwithmixedpolarizaBon?
Rahmanetal.(2004)CellularEffectsofAcuteDirectCurrentSPmulaPon:
SomaPcandSynapPcTerminalEffects.JournalofPhysiology.2013
•  Input/OutputsensiPvetoanodalpolarizaPononly
Lafonetal.(2016)DirectCurrentSPmulaPonaltersneuronalinput/output
funcPon.BrainSPmulaPon
•  Input/OutputsensiPvetoanodalpolarizaPononly
•  OnapopulaPonlevelnetchangeinmixedpolarizaPon
Lafonetal.(2016)DirectCurrentSPmulaPonaltersneuronalinput/output
funcPon.BrainSPmulaPon
•  NetworkacPvity“binds”oppositepolarizedregionsto
produceacoherenteffects
Reatoetal.(2013)TranscranialelectricalsPmulaPonaccelerateshumansleep
homeostasis.PLOSComputaPonBiology
•  PreferenPalenhancementofplasPcitybyanodaltDCS
Rahmanetal.(2016)InRevision