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JWH-018 and AM2201 metabolism. Aminoalkylindole synthetic cannabinoid JWH-018 and its omega fluorinated analog AM2201 undergo oxidation by
CYP2C9 and CYP1A9 to primary metabolites that retain affinity and ability to bind with cannabinoid receptors. One JWH-018 primary metabolite, acts as a
antagonist at CB1. Secondary metabolites are formed by conjugation. These metabolites may retain ability to bind to cannabinoid receptors but at this time
it is clear which do so and in what capacity (agonist, antagonist, or inverse agonist). (Adapted with permission from Chimalakonda KC, Seely KA, Bratton
SM, et al.: Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid
receptor ligands. Drug Metab Dispos. 2012;40:2174–2184.)
Source: Cannabinoids, Goldfrank's Toxicologic Emergencies, 10e
Citation: Hoffman RS, Howland M, Lewin NA, Nelson LS, Goldfrank LR. Goldfrank's Toxicologic Emergencies, 10e; 2015 Available at:
http://mhmedical.com/ Accessed: May 11, 2017
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