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Download NC-PB-22 8-Hydroxyisoquinoline isomer-2013-08
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Health Canada Santé Canada STATUS DECISION OF CONTROLLED AND NON-CONTROLLED SUBSTANCE(S) Substance: PB-22 8-Hydroxyisoquinoline isomer Based on the current information available to the Office of Controlled Substances, it appears that the above substance is: Controlled Not Controlled ☐ X under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s): The efficacy of PB-22 8-Hydroxyisoquinoline isomer as a cannabinoid receptor agonist has not been established and therefore the substance cannot be included under item 1 of Schedule II to the CDSA. Prepared by: _______________________________________ Vincent Marleau Date: _______________ Verified by: Date: ________________ _______________________________________ Mark Kozlowski Approved by: _______________________________________ Date: ________________ DIRECTOR, OFFICE OF CONTROLLED SUBSTANCES This status was requested by: “third party information removed as per agreement with applicant” 2 Drug Status Report Drug: PB-22 8-Hydroxyisoquinoline isomer Drug Name Status: PB-22 8-Hydroxyisoquinoline isomer is the common name. Chemical Name: Isoquinolin-8-yl 1-pentyl-1H-indole-3-carboxylate Chemical structure: Molecular Formula: C23H22N2O2 CAS-RN: N/A Pharmacological class / Application: Synthetic cannabinoid International status: US: PB-22 8-Hydroxyisoquinoline isomer is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website. United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic Substances under International Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control. Canadian Status: PB-22 8-Hydroxyisoquinoline isomer is not listed in the Schedules to the CDSA. The substance is a synthetic cannabinoid but there are currently no reports in the scientific literature on the efficacy of the substance as a cannabinoid receptor agonist. Cannabinoid receptor agonists are captured under item 1 of Schedule II to the CDSA by virtue of being “similar synthetic preparations” while cannabinoid receptor antagonists are not included under Schedule II to the CDSA. Since it cannot be established whether this substance is an efficient cannabinoid receptor agonist, PB-22 8-Hydroxyisoquinoline isomer cannot be included under item 1 of Schedule II to the CDSA. Recommendation: PB-22 8-Hydroxyisoquinoline isomer is not included in the schedules to the CDSA and is not a controlled substance. Date: August 1st, 2013.