“Psychoactive substances present in Salvia divinorum acquired in
... Nowadays, Salvia divinorum is considered one of the most popular recreational drugs among adolescents, being legally commercialized in many countries in “smart shops” and internet websites. In the present research, the hallucinogenic compound of the drug, salvinorin A, was identified and quantified, ...
... Nowadays, Salvia divinorum is considered one of the most popular recreational drugs among adolescents, being legally commercialized in many countries in “smart shops” and internet websites. In the present research, the hallucinogenic compound of the drug, salvinorin A, was identified and quantified, ...
- University of Glasgow
... Respiration is a complex rhythmic motor behaviour that metabolically supports all physiological processes in the body and is continuous throughout the life of mammals. A failure to generate a respiratory rhythm can be fatal. Understanding how the respiratory rhythm is generated by the brainstem pres ...
... Respiration is a complex rhythmic motor behaviour that metabolically supports all physiological processes in the body and is continuous throughout the life of mammals. A failure to generate a respiratory rhythm can be fatal. Understanding how the respiratory rhythm is generated by the brainstem pres ...
Dextromethorphan Pre
... Dextrometorphan, an oral drug, is available as lozenges, capsules, tablets, and cough syrups, in a variety of prescription medications and over-the-counter cough and cold remedies. Products contain dextromethorphan alone or in combination with guaifenesin, brompheniramine, pseudoephedrine, phenyleph ...
... Dextrometorphan, an oral drug, is available as lozenges, capsules, tablets, and cough syrups, in a variety of prescription medications and over-the-counter cough and cold remedies. Products contain dextromethorphan alone or in combination with guaifenesin, brompheniramine, pseudoephedrine, phenyleph ...
Enhancing the Delivery of Resveratrol in Humans
... bioavailability at tolerable doses—a common issue in translating promising findings from cell culture and animal models into clinical efficacious drugs. There are a number of mechanisms to explore which can be employed to potentially enhance the delivery of resveratrol to achieve therapeutic range. ...
... bioavailability at tolerable doses—a common issue in translating promising findings from cell culture and animal models into clinical efficacious drugs. There are a number of mechanisms to explore which can be employed to potentially enhance the delivery of resveratrol to achieve therapeutic range. ...
Chapter 1 - Overview of Nicotine Withdrawal and Negative
... emphasizing the key role of nicotine in tobacco dependence (Palazzolo, 2013). According to the latest report from Bloomberg Industries, the combined sales of electronic cigarettes have doubled every year for the past 5 years, generating over USD$1 billion in revenue in the United States in 2014. The ...
... emphasizing the key role of nicotine in tobacco dependence (Palazzolo, 2013). According to the latest report from Bloomberg Industries, the combined sales of electronic cigarettes have doubled every year for the past 5 years, generating over USD$1 billion in revenue in the United States in 2014. The ...
Buprenorphine (with or without naloxone)
... Tablets can also be more easily diverted than liquids, because of their longer absorption time. Buprenorphine is safer in overdose Buprenorphine has a better safety profile in overdose when not used in combination with other drugs than does methadone. This is due to the partial agonist effect that c ...
... Tablets can also be more easily diverted than liquids, because of their longer absorption time. Buprenorphine is safer in overdose Buprenorphine has a better safety profile in overdose when not used in combination with other drugs than does methadone. This is due to the partial agonist effect that c ...
Full Text
... uncontrolled status epilepticus (Dravet et al., 2005; Ceulemans et al., 2012). Delayed language development, disruption of autonomic function, and motor and cognitive impairment are also associated with this disease. Seizure management includes treatment with benzodiazepines, valproate, and/or stiri ...
... uncontrolled status epilepticus (Dravet et al., 2005; Ceulemans et al., 2012). Delayed language development, disruption of autonomic function, and motor and cognitive impairment are also associated with this disease. Seizure management includes treatment with benzodiazepines, valproate, and/or stiri ...
Neuroendocrine Control of Growth Hormone Secretion
... neurotransmitters, especially the noradrenergic and cholinergic ones and other hypothalamic neuropeptides, and are the final mediators of metabolic, endocrine, neural, and immune influences for the secretion of GH. Since the identification of the GHRH peptide, recombinant DNA procedures have been us ...
... neurotransmitters, especially the noradrenergic and cholinergic ones and other hypothalamic neuropeptides, and are the final mediators of metabolic, endocrine, neural, and immune influences for the secretion of GH. Since the identification of the GHRH peptide, recombinant DNA procedures have been us ...
FOP - The IFOPA
... to go fast, go alone; if you want to go far, go together.” This is your community; this is your dream. It’s our dream too. ...
... to go fast, go alone; if you want to go far, go together.” This is your community; this is your dream. It’s our dream too. ...
Advances in Pharmacological Research of Eugenol
... most phenols. Eugenol captures oxygen atoms by devoting hydrogen atoms and reducing free radical generation to achieve its antioxidant function. However, further studies are needed to determine the mechanism of eugenol that is related to some enzymes and the electron transport system and to reveal f ...
... most phenols. Eugenol captures oxygen atoms by devoting hydrogen atoms and reducing free radical generation to achieve its antioxidant function. However, further studies are needed to determine the mechanism of eugenol that is related to some enzymes and the electron transport system and to reveal f ...
aspartate Antagonists on a Multiple Schedule of Ethanol and
... (AP-5) and 2-amino-7-phosphonoheptanoic acid (AP-7) directly into the nucleus accumbens attenuate operant responding for 10% ethanol without affecting baseline levels of water self-administration (Rassnick et al., 1992a,b). Many studies have examined drug effects on ethanol selfadministration behavi ...
... (AP-5) and 2-amino-7-phosphonoheptanoic acid (AP-7) directly into the nucleus accumbens attenuate operant responding for 10% ethanol without affecting baseline levels of water self-administration (Rassnick et al., 1992a,b). Many studies have examined drug effects on ethanol selfadministration behavi ...
Discriminative Stimulus Properties of MDMA
... mention of MDMA will refer to racemic MDMA unless otherwise stated. The pharmacology of MDMA has been studied extensively in animals. MDMA penetrates the blood brain barrier and interacts with several recognition sites in the central nervous system (CNS), but displays the strongest affinity for the ...
... mention of MDMA will refer to racemic MDMA unless otherwise stated. The pharmacology of MDMA has been studied extensively in animals. MDMA penetrates the blood brain barrier and interacts with several recognition sites in the central nervous system (CNS), but displays the strongest affinity for the ...
Download CV
... Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhib ...
... Wozniak K, Yudkoff M, Jackson PF. “An inhibitor of NAAG hydrolysis prevents ischemic glutamate release and provides neuroprotection.” Nature Medicine, 1999, 5:1396-1402 Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhib ...
A Literature Review on the Status and Effects of Salvia Divinorum on
... Salvia divinorum is one of more than 700 members of the plant genus “salvia,” and is considered a member of the sage and mint family (Valdes & Seymour, 1998). Salvia divinorum was primarily used by the Mazatec Indian culture of Oaxaca, Mexico for medicinal and spiritual purposes (Wasson, 1962). Medi ...
... Salvia divinorum is one of more than 700 members of the plant genus “salvia,” and is considered a member of the sage and mint family (Valdes & Seymour, 1998). Salvia divinorum was primarily used by the Mazatec Indian culture of Oaxaca, Mexico for medicinal and spiritual purposes (Wasson, 1962). Medi ...
ibogaine: a review
... reported binding affinities in the range of 0.13 to 26 µM (40,45,64,66), with one study reporting a result in excess of 100 µM (43). Ibogaine behaves as an agonist in a functional assay for mu-opioid receptors, the binding of [35S]-GTPγS (65). However, some observations are difficult to reconcile wi ...
... reported binding affinities in the range of 0.13 to 26 µM (40,45,64,66), with one study reporting a result in excess of 100 µM (43). Ibogaine behaves as an agonist in a functional assay for mu-opioid receptors, the binding of [35S]-GTPγS (65). However, some observations are difficult to reconcile wi ...
GHB, GBL and 1,4-BD Addiction - Trimbos
... In addition, GBL is more lipophilic than GHB and the enzyme lactonase can vary genetically between individuals, which means that GBL can display even more unpredictable results, especially in first-time users [59]. 4. NEUROBIOLOGICAL TARGETS: GHB- AND GABA RECEPTOR SYSTEMS GHB has been proposed as a ...
... In addition, GBL is more lipophilic than GHB and the enzyme lactonase can vary genetically between individuals, which means that GBL can display even more unpredictable results, especially in first-time users [59]. 4. NEUROBIOLOGICAL TARGETS: GHB- AND GABA RECEPTOR SYSTEMS GHB has been proposed as a ...
Contrasting Actions of Lanthanum on Different Recombinant
... Multipuffer system to apply a range of different concentrations of drugs. To enable fast application of a number of different concentrations and types of drug, a multipuffer application system was designed in the laboratory (17). Briefly, it consisted of a T-tube device with inlet and outlet ports f ...
... Multipuffer system to apply a range of different concentrations of drugs. To enable fast application of a number of different concentrations and types of drug, a multipuffer application system was designed in the laboratory (17). Briefly, it consisted of a T-tube device with inlet and outlet ports f ...
Adenine Nucleotides Undergo Rapid, Quantitative Conversion to
... receptors; the conversion processes may simply be so effective that the nucleotides are metabolized to adenosine before they have the opportunity to exert any direct actions. It has been reported that stable nucleotide analogs can mimic the effects of adenosine (Lee et al., 1981; Wiklund et al., 198 ...
... receptors; the conversion processes may simply be so effective that the nucleotides are metabolized to adenosine before they have the opportunity to exert any direct actions. It has been reported that stable nucleotide analogs can mimic the effects of adenosine (Lee et al., 1981; Wiklund et al., 198 ...
The Pharmacology of Lysergic Acid Diethylamide: A Review
... LSD dosage has remained fairly constant since the 1970 ...
... LSD dosage has remained fairly constant since the 1970 ...
Ann N Y Acad Sci
... However, the use of opioids to treat patients with chronic non-cancer pain is controversial because of concerns about efficacy and safety, and the possibility of addiction or abuse. The results of clinical surveys and retrospective case series involving patients with non-cancer chronic pain have bee ...
... However, the use of opioids to treat patients with chronic non-cancer pain is controversial because of concerns about efficacy and safety, and the possibility of addiction or abuse. The results of clinical surveys and retrospective case series involving patients with non-cancer chronic pain have bee ...
Oxycodone - Thblack.com
... Intramuscular oxymorphone and morphine were compared in patients with chronic pain due to cancer. Intramuscular oxymorphone proved to be 8.7 times as potent as morphine in terms of total analgesic effect and 13 times as potent in terms of peak effect.19 In behavioral studies in rats, oxycodone has b ...
... Intramuscular oxymorphone and morphine were compared in patients with chronic pain due to cancer. Intramuscular oxymorphone proved to be 8.7 times as potent as morphine in terms of total analgesic effect and 13 times as potent in terms of peak effect.19 In behavioral studies in rats, oxycodone has b ...
Fear Conditioning
... a. D1 antagonist blocks NPS self-administration b. D1 antagonist SCH 23390 also blocks NPS stimulated locomotion 4. NPS → NPSR → ↑ DMH/PF → ↑ Orx activity 5. Orx1 receptor antagonist blocks NPS self-administration a. Orx1 antagonist SB 334867 has no effect on locomotion 6. NPS at a high 1,000 pmol d ...
... a. D1 antagonist blocks NPS self-administration b. D1 antagonist SCH 23390 also blocks NPS stimulated locomotion 4. NPS → NPSR → ↑ DMH/PF → ↑ Orx activity 5. Orx1 receptor antagonist blocks NPS self-administration a. Orx1 antagonist SB 334867 has no effect on locomotion 6. NPS at a high 1,000 pmol d ...
Acute and Chronic Effects of Inhalants in Intracranial Self
... Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. Broadly defined, ...
... Inhalants are a pharmacologically diverse group of compounds that have been ubiquitously defined through the exclusivity of the inhalational route by which humans abuse them. In addition, inhalants are associated with their legal, therapeutic and commercial availability in society. Broadly defined, ...