Michelle Zarr
... spontaneous firing rates of mPFC neurons D2 and D4 activation weakened BLA-evoked inhibition in a subpopulation of mPFC neurons May then increase effects of excitatory inputs from BLA Also found one mPFC(-) neuron that acted as a monosynaptic mPFC(+) neuron in the presence of D1 agonist SKF 81 ...
... spontaneous firing rates of mPFC neurons D2 and D4 activation weakened BLA-evoked inhibition in a subpopulation of mPFC neurons May then increase effects of excitatory inputs from BLA Also found one mPFC(-) neuron that acted as a monosynaptic mPFC(+) neuron in the presence of D1 agonist SKF 81 ...
The Effects of Nicotine Conditioned Place Preference in D2 Primed
... originates from a clinical study using an NMDA receptor antagonist, phencyclidine (PCP) (Luby, Cohen, Rosenbaum, Gottlieb, & Kelly, 1959). Luby et al. revealed that PCP produces similar symptoms to those observed in schizophrenics. Similarly, Holcomb, Lahti, Medoff, Cullen, and Tamminga (2005) condu ...
... originates from a clinical study using an NMDA receptor antagonist, phencyclidine (PCP) (Luby, Cohen, Rosenbaum, Gottlieb, & Kelly, 1959). Luby et al. revealed that PCP produces similar symptoms to those observed in schizophrenics. Similarly, Holcomb, Lahti, Medoff, Cullen, and Tamminga (2005) condu ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... codeine to morphine. Morphine derived from O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than mo ...
... codeine to morphine. Morphine derived from O-demethylation of codeine has been shown to account for most, if not all, of the analgesic activity of codeine.6,7 Oxymorphone is a remarkably potent -opioid ligand, with 2 to 5 times higher -opioid receptor affinity and in vivo analgesic potency than mo ...
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[Salvia divinorum - a potential drug for abuse]
... Selective kappa receptoragonists have been shown to produce analgesic effects with potential for reduced tolerance and dependence. However, psychotomimesis (hallucinogenic and/or psychotic effects), dysphoria and diuresis have been observed with their therapeutic use (Tidgewell et aI., 2004). In add ...
... Selective kappa receptoragonists have been shown to produce analgesic effects with potential for reduced tolerance and dependence. However, psychotomimesis (hallucinogenic and/or psychotic effects), dysphoria and diuresis have been observed with their therapeutic use (Tidgewell et aI., 2004). In add ...
ABSTRACT Title of Dissertation: ENERGETICS OF DRUG INTERACTIONS
... compensation where changes in the binding enthalpies are compensated by changes in the binding entropies. In drug binding to the more flexible p38α MAP kinase mutants, a single-point C→S mutation distal from the binding site, changes the interaction between the N- and C-terminal structural domains o ...
... compensation where changes in the binding enthalpies are compensated by changes in the binding entropies. In drug binding to the more flexible p38α MAP kinase mutants, a single-point C→S mutation distal from the binding site, changes the interaction between the N- and C-terminal structural domains o ...
Nicotine sensitization and the effects of extended withdrawal
... Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits ...
... Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits ...
The Essential Medicinal Chemistry of Curcumin
... Chicago. Founded by the late Professor Norman R. Farnsworth, NAPRALERT has since compiled data from more than 190 000 literature references, with records of over 200 000 distinct chemical compounds from more than 60 000 species of organisms. As a result, NAPRALERT covers hundreds of thousands of rep ...
... Chicago. Founded by the late Professor Norman R. Farnsworth, NAPRALERT has since compiled data from more than 190 000 literature references, with records of over 200 000 distinct chemical compounds from more than 60 000 species of organisms. As a result, NAPRALERT covers hundreds of thousands of rep ...
Synthetic cannabinoids in herbal products
... 1 Introduction and chemistry of synthetic cannabinoids ....................................................................................... 3 1.1 Emergence of synthetic cannabinoids in herbal products ................................................................................ 3 1.2 Defini ...
... 1 Introduction and chemistry of synthetic cannabinoids ....................................................................................... 3 1.1 Emergence of synthetic cannabinoids in herbal products ................................................................................ 3 1.2 Defini ...
NATURAL AND PARTIALLY SYNTETIc ANALGESIcS
... and constitution of which are still hard to explain. Metopon has been studied clinically only in cases of inoperable cancer. It is administered orally and has been found to possess few undesirable side-effects (10). The addiction to which it gives rise is less marked than that caused by morphine. De ...
... and constitution of which are still hard to explain. Metopon has been studied clinically only in cases of inoperable cancer. It is administered orally and has been found to possess few undesirable side-effects (10). The addiction to which it gives rise is less marked than that caused by morphine. De ...
Hypothesizing that Putative Dopaminergic, Melatonin
... hypnotic–abuse liability and toxicity has been a real challenge for the pharmaceutical industry. Griffiths et al. [28] evaluated 19 hypnotic drugs for both abuse liability and toxicity and found that Phenobarbital has the highest abuse liability and toxicity and Trazodone (a nonapproved anti-insomni ...
... hypnotic–abuse liability and toxicity has been a real challenge for the pharmaceutical industry. Griffiths et al. [28] evaluated 19 hypnotic drugs for both abuse liability and toxicity and found that Phenobarbital has the highest abuse liability and toxicity and Trazodone (a nonapproved anti-insomni ...
Pediatric allergic rhinitis: Factors affecting treatment
... range of criteria should be borne in mind when making this selection, including efficacy, onset and duration of action, and safety profile because there are important differences among the antihistamines in each of these areas. ...
... range of criteria should be borne in mind when making this selection, including efficacy, onset and duration of action, and safety profile because there are important differences among the antihistamines in each of these areas. ...
In Vitro Metabolism of Haloperidol and Sila-Haloperidol
... Fexofenadine is a histaminic H1 receptor antagonist used in the treatment of allergies. The sila analog of fexofenadine was synthesized to compare the pharmacological properties. Fexofenadine and sila-fexofenadine displayed similar receptor profiles when tested against a panel of histamine receptors ...
... Fexofenadine is a histaminic H1 receptor antagonist used in the treatment of allergies. The sila analog of fexofenadine was synthesized to compare the pharmacological properties. Fexofenadine and sila-fexofenadine displayed similar receptor profiles when tested against a panel of histamine receptors ...
C 5 P450
... -ionone hydroxylation (12) . This position was mutated in M11 to the negative charged residue Glu (L437E) and to three polar residues Asn (L437N), Ser (L437S), and Thr (L437T), which differ in size and hydrogen bonding capabilities. 5.2.4. Metabolism of TAK-715 by P450 BM3 mutants and human liver m ...
... -ionone hydroxylation (12) . This position was mutated in M11 to the negative charged residue Glu (L437E) and to three polar residues Asn (L437N), Ser (L437S), and Thr (L437T), which differ in size and hydrogen bonding capabilities. 5.2.4. Metabolism of TAK-715 by P450 BM3 mutants and human liver m ...
NIDA Monograph 169 - pg. 83-104
... indicating that these rats were more sensitive to the reinforcing effects of cocaine at every dose except the highest dose tested (i.e., 0.5 mg/kg/infusion). It is important to note that even though the first and second rats from each triad received the same number of electric footshocks at the same ...
... indicating that these rats were more sensitive to the reinforcing effects of cocaine at every dose except the highest dose tested (i.e., 0.5 mg/kg/infusion). It is important to note that even though the first and second rats from each triad received the same number of electric footshocks at the same ...
Saffron (Crocus sativus L.) and morphine
... (Hosseinzadeh H. 2010). Thus, the interaction of this constituent with the opioid system should be more specific. Administration of safranal potentiated some signs of withdrawal syndrome. Then, it seems that the aqueous and ethanolic extracts and crocin may have interaction with the opioid system to ...
... (Hosseinzadeh H. 2010). Thus, the interaction of this constituent with the opioid system should be more specific. Administration of safranal potentiated some signs of withdrawal syndrome. Then, it seems that the aqueous and ethanolic extracts and crocin may have interaction with the opioid system to ...
Structural Basis for Interaction of Inhibitors with Cyclin
... ATP and cyclin A [31] clearly shows that there are five significant conformational changes: (a) the two domains are more open in the ternary complex, thus, pushing the phosphate-loop (P loop) toward the N-terminal domain; (b) the conformation of the triphosphate of ATP and surrounding residues are d ...
... ATP and cyclin A [31] clearly shows that there are five significant conformational changes: (a) the two domains are more open in the ternary complex, thus, pushing the phosphate-loop (P loop) toward the N-terminal domain; (b) the conformation of the triphosphate of ATP and surrounding residues are d ...
Buprenorphine And The Anesthesia Considerations: A
... in the bile and eliminated in the feces. Buprenorphine is both lipophilic and highly protein bound. It is distributed to adipose tissue and slowly redistributed to plasma, extending the half-life. The half-life is route and dose dependent. Higher doses are utilized in BMT whereas significantly lower ...
... in the bile and eliminated in the feces. Buprenorphine is both lipophilic and highly protein bound. It is distributed to adipose tissue and slowly redistributed to plasma, extending the half-life. The half-life is route and dose dependent. Higher doses are utilized in BMT whereas significantly lower ...
CRF Enhancement of GIRK Channel-Mediated
... Whole-cell voltage clamp recordings were made from dopamine neurons in horizontal slices of mouse midbrain. Dopamine-mediated IPSCs were evoked in the presence of pharmacological blockers of glutamate, GABA, and nicotinic acetylcholine receptors. Perfusion of CRF produced a concentration-dependent e ...
... Whole-cell voltage clamp recordings were made from dopamine neurons in horizontal slices of mouse midbrain. Dopamine-mediated IPSCs were evoked in the presence of pharmacological blockers of glutamate, GABA, and nicotinic acetylcholine receptors. Perfusion of CRF produced a concentration-dependent e ...
as a PDF
... considerable variability between patients in clinical response to glucocorticoid treatment. The pharmacokinetics and pharmacodynamics of glucocorticoids have therefore been evaluated in many studies. Generally, the indications for glucocorticoids can be divided into two categories. The first categor ...
... considerable variability between patients in clinical response to glucocorticoid treatment. The pharmacokinetics and pharmacodynamics of glucocorticoids have therefore been evaluated in many studies. Generally, the indications for glucocorticoids can be divided into two categories. The first categor ...
cocaine-induced behavioral sensitization and
... locomotor activity between male and female Japanese quail and I examined the potential role of gonadal hormones in these effects. Results from Experiment 1 indicated that cocaine-induced locomotor activity correlates with testosterone in male quail. Surprisingly, cocaine-induced activity did not cor ...
... locomotor activity between male and female Japanese quail and I examined the potential role of gonadal hormones in these effects. Results from Experiment 1 indicated that cocaine-induced locomotor activity correlates with testosterone in male quail. Surprisingly, cocaine-induced activity did not cor ...
The Sleep - American Osteopathic Association
... Antidepressants • Hypnotic properties most strongly related to antagonism of serotonin 5-HT2, histamine H1, and α1 adrenergic receptors • Commonly used medications include trazodone, mirtazapine, amitriptyline, and doxepin • Doses used for insomnia are much lower than those used for depression • Do ...
... Antidepressants • Hypnotic properties most strongly related to antagonism of serotonin 5-HT2, histamine H1, and α1 adrenergic receptors • Commonly used medications include trazodone, mirtazapine, amitriptyline, and doxepin • Doses used for insomnia are much lower than those used for depression • Do ...
lec8.Treatment of Cough
... ) مهمهconduction from these receptors is via fibers in the vagus nerve; central components of the reflex probably involve several mechanisms or centres that are distinct تختلف عنfrom the mechanisms involved in the regulation of respiration. ...
... ) مهمهconduction from these receptors is via fibers in the vagus nerve; central components of the reflex probably involve several mechanisms or centres that are distinct تختلف عنfrom the mechanisms involved in the regulation of respiration. ...