Which neuroreceptors mediate the subjective effects of MDMA in
... contributes to the acute psychoactive effects of MDMA in humans and whether SSRI treatment would reduce the acute mood effects in humans, as expected from animal studies. There are a few anecdotal reports that SSRIs, when used together with Ecstasy, dampened subjective and adverse responses to Ecsta ...
... contributes to the acute psychoactive effects of MDMA in humans and whether SSRI treatment would reduce the acute mood effects in humans, as expected from animal studies. There are a few anecdotal reports that SSRIs, when used together with Ecstasy, dampened subjective and adverse responses to Ecsta ...
Opioid Analgesics
... Mosby items and derived items © 2007 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Mosby items and derived items © 2007 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... synthesized in neuronal cells, including cortical and striatal neurons, but not astrocytes, and their synthesis is increased in response to membrane depolarization. Specific membrane depolarization-induced release is characteristic of classical neurotransmitters. However, in contrast to classical ne ...
Pharmacology of Hemostasis and Thrombosis
... Figure 22-5. Platelet activation by ADP and thrombin. Left panel: 1. Binding of ADP to the P2Y(ADP) receptor activates a Gi protein, which inhibits adenylyl cyclase. 2. Inhibition of adenylyl cyclase decreases the synthesis of cAMP, and hence decreases protein kinase A (PKA) activation (dashed arrow ...
... Figure 22-5. Platelet activation by ADP and thrombin. Left panel: 1. Binding of ADP to the P2Y(ADP) receptor activates a Gi protein, which inhibits adenylyl cyclase. 2. Inhibition of adenylyl cyclase decreases the synthesis of cAMP, and hence decreases protein kinase A (PKA) activation (dashed arrow ...
Side Effects of Anabolic Androgenic Steroids
... receptor–ligand complex migrates into the cell nucleus and binds to a specific sequence of the DNA, leading to transcriptional activation of protein synthesis. Moreover, anticatabolic effects based on glucocorticoid receptor inhibition may contribute to anabolic effects. The process is controlled by ...
... receptor–ligand complex migrates into the cell nucleus and binds to a specific sequence of the DNA, leading to transcriptional activation of protein synthesis. Moreover, anticatabolic effects based on glucocorticoid receptor inhibition may contribute to anabolic effects. The process is controlled by ...
New insights into enhancing morphine analgesia Tuomas
... The treatment of acute and chronic severe pain remains a major challenge. Opioids, such as morphine and oxycodone, are used as primary analgesics in moderate to severe pain (Hoskin, 2008; Kalso et al., 2004). However, long-term opioid treatment, in particular, has several problems, such as the devel ...
... The treatment of acute and chronic severe pain remains a major challenge. Opioids, such as morphine and oxycodone, are used as primary analgesics in moderate to severe pain (Hoskin, 2008; Kalso et al., 2004). However, long-term opioid treatment, in particular, has several problems, such as the devel ...
Protective Effects of Aqueous and Alcoholic Extracts of Piper longum
... Epilepsy affects 5 to 10 per 1000 of the general population. It is the third most common neurological disorder after stroke and Alzheimer's disease. Available anti-convulsant drugs effectively control epilepsy in about 50% of the patients. Many epileptic seizures are refractory to current anti-epile ...
... Epilepsy affects 5 to 10 per 1000 of the general population. It is the third most common neurological disorder after stroke and Alzheimer's disease. Available anti-convulsant drugs effectively control epilepsy in about 50% of the patients. Many epileptic seizures are refractory to current anti-epile ...
Effect of levetiracetam on penicillin induced epileptic activity in rats
... LEV prevents epileptic seizures by anew mechanism. In 1995, the binding site for LEV has been identified in brain membranes (Noyer et al. 1995). This binding side is an integral protein that is localized on neurons’ synaptic membrane fraction and is widely distributed. This binding protein was named ...
... LEV prevents epileptic seizures by anew mechanism. In 1995, the binding site for LEV has been identified in brain membranes (Noyer et al. 1995). This binding side is an integral protein that is localized on neurons’ synaptic membrane fraction and is widely distributed. This binding protein was named ...
Valerian (Valeriana officinalis) Nervousness Insomnia Anxiety
... as the mechanism responsible for its sedative effect. GABA is one of the major inhibitory neurotransmitters in the central nervous system and GABA-A is the target of many drugs used to reduce anxiety or aid sleep, such as benzodiazepines. Valerenic acid and valerenol are two compounds in valerian ro ...
... as the mechanism responsible for its sedative effect. GABA is one of the major inhibitory neurotransmitters in the central nervous system and GABA-A is the target of many drugs used to reduce anxiety or aid sleep, such as benzodiazepines. Valerenic acid and valerenol are two compounds in valerian ro ...
The leukotriene-receptor antagonist MK-0679
... been reported that this group of asthmatics may be exceptionally hyperresponsive to cysteinyl-leukotrienes, and perhaps especially to LTE4 [17] Since ASA-provocation is associated with release of leukotrienes into body fluids, the second criteria of a putative mediator ("endogenous formation by appr ...
... been reported that this group of asthmatics may be exceptionally hyperresponsive to cysteinyl-leukotrienes, and perhaps especially to LTE4 [17] Since ASA-provocation is associated with release of leukotrienes into body fluids, the second criteria of a putative mediator ("endogenous formation by appr ...
Influence of Gender and Sex Hormones on Nicotine Acute
... nicotine is the addictive substance found in tobacco. In 1974, 31% of U.S. women and 43% of U.S. men were tobacco smokers. Current estimates indicate that the difference between men and women has narrowed considerably to a comparable rate (21–25%) (CDC, 1998). Furthermore, poorer outcome of women in ...
... nicotine is the addictive substance found in tobacco. In 1974, 31% of U.S. women and 43% of U.S. men were tobacco smokers. Current estimates indicate that the difference between men and women has narrowed considerably to a comparable rate (21–25%) (CDC, 1998). Furthermore, poorer outcome of women in ...
Liver X Receptor Agonists as Potential Therapeutic Agents for
... activation.43 Although caution must be exercised in interpreting these studies, taken together with the evidence on n-3 fatty acids, it is reasonable to expect that LXR agonists will increase both HDL and triglyceride in humans. Dissociating this expected dual effect is the great challenge for the d ...
... activation.43 Although caution must be exercised in interpreting these studies, taken together with the evidence on n-3 fatty acids, it is reasonable to expect that LXR agonists will increase both HDL and triglyceride in humans. Dissociating this expected dual effect is the great challenge for the d ...
Evaluation of the Anti Platelet Aggregation Effects of Diltiazem
... no significant alteration in platelet aggregation in whole blood and PRP between normal and experimental group [11]. Which is in contrast of our study and shows that probably there exists a difference between the Ca++ channel blockers that needs further exploration. Calcium channel blockers. Blache ...
... no significant alteration in platelet aggregation in whole blood and PRP between normal and experimental group [11]. Which is in contrast of our study and shows that probably there exists a difference between the Ca++ channel blockers that needs further exploration. Calcium channel blockers. Blache ...
Enhancing Cannabinoid Neurotransmission
... fear and anxiety in humans suffering from phobias, PostTraumatic Stress Disorder (PTSD), and other anxiety disorders to the expression of classically conditioned fear in animals. Perhaps the most important of these similarities is the persistence of fear memories in both humans and animal models. In ...
... fear and anxiety in humans suffering from phobias, PostTraumatic Stress Disorder (PTSD), and other anxiety disorders to the expression of classically conditioned fear in animals. Perhaps the most important of these similarities is the persistence of fear memories in both humans and animal models. In ...
Aldosterone and end-organ damage
... acts as the primary ligand at the MR. In contrast, neither cardiomyocytes nor hippocampal cells express 11βHSD2 [8]. Therefore cortisol, present in concentrations at least 10-fold in excess of aldosterone, acts as the primary MR ligand at these sites. Paradoxically, under normal redox conditions, co ...
... acts as the primary ligand at the MR. In contrast, neither cardiomyocytes nor hippocampal cells express 11βHSD2 [8]. Therefore cortisol, present in concentrations at least 10-fold in excess of aldosterone, acts as the primary MR ligand at these sites. Paradoxically, under normal redox conditions, co ...
SYNTHESIS AND CHARACTERIZATION OF NEW AZO DYE (1
... and negative gram stain. The purity of the dye was checked by thin layer chromatography(TLC) using solvent system( sec.Butanol-water-acetic acid)(2:2:1).The melting point of the purified dye was measured in an open capillary tube. We have been concluded that the prepared azo dye showed antibacterial ...
... and negative gram stain. The purity of the dye was checked by thin layer chromatography(TLC) using solvent system( sec.Butanol-water-acetic acid)(2:2:1).The melting point of the purified dye was measured in an open capillary tube. We have been concluded that the prepared azo dye showed antibacterial ...
Cannabidiol: Pharmacology and potential therapeutic role
... To present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regard to its relevance to epilepsy and other selected neuropsychiatric disorders. We summarize the presentations from a conference in which invited participants reviewed relevant aspects of the physiol ...
... To present a summary of current scientific evidence about the cannabinoid, cannabidiol (CBD) with regard to its relevance to epilepsy and other selected neuropsychiatric disorders. We summarize the presentations from a conference in which invited participants reviewed relevant aspects of the physiol ...
as a PDF
... high- and low-frequency TENS works still remain unclear. In response to the conflicting results of previous studies and the lack of research on the mechanisms through which TENS works, this study investigated the spinal mechanisms through which low- and high-frequency TENS exert their antihyperalges ...
... high- and low-frequency TENS works still remain unclear. In response to the conflicting results of previous studies and the lack of research on the mechanisms through which TENS works, this study investigated the spinal mechanisms through which low- and high-frequency TENS exert their antihyperalges ...
Spinal Blockade of Opioid Receptors Prevents the Analgesia
... high- and low-frequency TENS works still remain unclear. In response to the conflicting results of previous studies and the lack of research on the mechanisms through which TENS works, this study investigated the spinal mechanisms through which low- and high-frequency TENS exert their antihyperalges ...
... high- and low-frequency TENS works still remain unclear. In response to the conflicting results of previous studies and the lack of research on the mechanisms through which TENS works, this study investigated the spinal mechanisms through which low- and high-frequency TENS exert their antihyperalges ...
