Design, Synthesis, and Actions of a Novel Chimeric Natriuretic Peptide
... have also reported that CNP possesses more potent antiproliferative and collagen-suppressing properties in cardiac fibroblasts (CFs) as compared with ANP and BNP (11). Relevant to such fibro-inhibiting properties, studies have shown that 14 days of continuous infusion of CNP in rodents with acute my ...
... have also reported that CNP possesses more potent antiproliferative and collagen-suppressing properties in cardiac fibroblasts (CFs) as compared with ANP and BNP (11). Relevant to such fibro-inhibiting properties, studies have shown that 14 days of continuous infusion of CNP in rodents with acute my ...
Neuroscience of psychoactive substance use and dependence Neur
... and, in particular, the ethical implications of new biological intervention strategies. The various health and social problems associated with use of and dependence on tobacco, alcohol and illicit substances require greater attention by the public health community and appropriate policy responses ar ...
... and, in particular, the ethical implications of new biological intervention strategies. The various health and social problems associated with use of and dependence on tobacco, alcohol and illicit substances require greater attention by the public health community and appropriate policy responses ar ...
The Effects of the Preferential 5
... of schizophrenia in humans (Vollenweider, 1998, 2001; Vollenweider and Geyer, 2001), PPI has been proposed as an animal model for detecting antipsychotic activity (Swerdlow et al, 1994; Swerdlow and Geyer, 1998). As a consequence, it was also supposed that the PPI deficit of schizophrenia patients i ...
... of schizophrenia in humans (Vollenweider, 1998, 2001; Vollenweider and Geyer, 2001), PPI has been proposed as an animal model for detecting antipsychotic activity (Swerdlow et al, 1994; Swerdlow and Geyer, 1998). As a consequence, it was also supposed that the PPI deficit of schizophrenia patients i ...
2009 St Johns Wort Quality Issues and Active Compounds
... of phase I proteins for rutin, which would lead to an increased bioavailability of simultaneously administered active SJW compounds ...
... of phase I proteins for rutin, which would lead to an increased bioavailability of simultaneously administered active SJW compounds ...
Characterization of Two Pharmacophores on the Multidrug
... Pascaud et al., 1998; Wang et al., 2000) all led to the same conclusion of several different specific sites on P-glycoprotein. However, the number of sites, their chemical selectivities, and their mutual relationships remain unclear. The molecular mechanism underlying the “multispecific” recognition ...
... Pascaud et al., 1998; Wang et al., 2000) all led to the same conclusion of several different specific sites on P-glycoprotein. However, the number of sites, their chemical selectivities, and their mutual relationships remain unclear. The molecular mechanism underlying the “multispecific” recognition ...
Dopamine-Serotonin System Stabilizer
... Aripiprazole, a novel antipsychotic agent, is assumed to be a “dopamine-serotonin system stabilizer”. According to preclinical studies, aripiprazole exerts partial agonistic action on D2 and 5-HT1A receptors. Thus, it may block a receptor if it is overstimulated and stimulate a receptor when activit ...
... Aripiprazole, a novel antipsychotic agent, is assumed to be a “dopamine-serotonin system stabilizer”. According to preclinical studies, aripiprazole exerts partial agonistic action on D2 and 5-HT1A receptors. Thus, it may block a receptor if it is overstimulated and stimulate a receptor when activit ...
Analgesic Effects of Topical Ketamine
... systemic side effects, and thus might increase compliance.2 One of the more potent topical analgesics is ketamine; it is especially suitable due to its lack of troublesome side effects even at concentrations up to 20%.3 Ketamine: early experience In 1962 ketamine, 2‐(2‐chlorophenyl)‐2‐(methylam ...
... systemic side effects, and thus might increase compliance.2 One of the more potent topical analgesics is ketamine; it is especially suitable due to its lack of troublesome side effects even at concentrations up to 20%.3 Ketamine: early experience In 1962 ketamine, 2‐(2‐chlorophenyl)‐2‐(methylam ...
Serum albumin, the most abundant protein in the
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
... Serum albumin, the most abundant protein in the circulatory system, has been one of the most extensively studied of all proteins 1. Serum albumins are prone to bind effectively many small organic molecules. Bovine serum albumin (BSA), a large globular protein (65,000 Daltons), consists of a single c ...
Pharmacologically Active Drug Metabolites: Impact on Drug
... 11. Donepezil . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 620 12. Granisetron. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
... 11. Donepezil . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 620 12. Granisetron. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
Carbonic Anhydrase Inhibitors and Activators: Small
... Cytosol Cytosol Membrane-bound Cytosol Cytosol Membrane-bound Unknown Membrane-bound ...
... Cytosol Cytosol Membrane-bound Cytosol Cytosol Membrane-bound Unknown Membrane-bound ...
Antimicrobial peptides: an overview of a promising class
... more than 80 different plant defensin genes from different plant species are available [20]. The second large family of AMPs in mammals is represented by cathelicidins. They are AMPs bearing an amino-terminal cathepsin L inhibitor domain (cathelin). The C-terminal 37 domain of the only human cathelici ...
... more than 80 different plant defensin genes from different plant species are available [20]. The second large family of AMPs in mammals is represented by cathelicidins. They are AMPs bearing an amino-terminal cathepsin L inhibitor domain (cathelin). The C-terminal 37 domain of the only human cathelici ...
A Common Anticonvulsant Binding Site for Phenytoin
... 1A). DPH is a hydantoin containing the ureide structure (Fig. 1B), which is traditionally viewed as an important structural motif responsible for antiepileptic activities. CBZ, however, does not contain the ureide structure and is a tricyclic compound with a very short amide side chain. LTG is an ev ...
... 1A). DPH is a hydantoin containing the ureide structure (Fig. 1B), which is traditionally viewed as an important structural motif responsible for antiepileptic activities. CBZ, however, does not contain the ureide structure and is a tricyclic compound with a very short amide side chain. LTG is an ev ...
Dynorphin A1–13 Stimulates Ovine Fetal Pituitary
... fact, not opioid mediated. Thus, a nonopioid component of HPA stimulation by the dynorphins is implied. In the present study, dynorphin A1–13 was capable of stimulating a highly significant and rapid rise in plasma ir-ACTH and ir-cortisol in the ovine fetus. The later peak in cortisol increase (30 m ...
... fact, not opioid mediated. Thus, a nonopioid component of HPA stimulation by the dynorphins is implied. In the present study, dynorphin A1–13 was capable of stimulating a highly significant and rapid rise in plasma ir-ACTH and ir-cortisol in the ovine fetus. The later peak in cortisol increase (30 m ...
Highly impulsive rats: modelling an endophenotype to determine the
... that is responsible for maladaptive impulsivity. Thus, animals that exhibit trait impulsivity have provided a useful experimental approach to the investigation of impulsivity. To date, a number of studies have identified particular strains of rodents that demonstrate increased levels of impulsivity ...
... that is responsible for maladaptive impulsivity. Thus, animals that exhibit trait impulsivity have provided a useful experimental approach to the investigation of impulsivity. To date, a number of studies have identified particular strains of rodents that demonstrate increased levels of impulsivity ...
Unit Assessment Keyed for Instructors
... • Direct students to visit the companion website to Nancy Caroline’s Emergency Care in the Streets, Seventh Edition, at http://www.paramedic.emszone.com for online activities. • The Federal Food and Drug Administration website: http://www.fda.gov/ • Content connections: The chapter on Medication Adm ...
... • Direct students to visit the companion website to Nancy Caroline’s Emergency Care in the Streets, Seventh Edition, at http://www.paramedic.emszone.com for online activities. • The Federal Food and Drug Administration website: http://www.fda.gov/ • Content connections: The chapter on Medication Adm ...
week5
... mammalian Nav channels but a reliable homology model for the pore domain is now available. • Pore domain of all Nav1.1 – Nav1.9 channels are very similar. There are differences in the turret region, which could play important roles in toxin binding. However no templates can be found for modelling th ...
... mammalian Nav channels but a reliable homology model for the pore domain is now available. • Pore domain of all Nav1.1 – Nav1.9 channels are very similar. There are differences in the turret region, which could play important roles in toxin binding. However no templates can be found for modelling th ...
cocaine 68, 111, 145, 150, 164, 192, 201, 208, 209, 226, 270, 274
... for cocaine abuse. Emerging preclinical and clinical data with the metabotropic GABAB receptor agonist baclofen support a role for the modulation of GABAB receptors in the treatment of drug addiction. Nevertheless, the muscle relaxant, hypothermic, and sedative properties of ba ...
... for cocaine abuse. Emerging preclinical and clinical data with the metabotropic GABAB receptor agonist baclofen support a role for the modulation of GABAB receptors in the treatment of drug addiction. Nevertheless, the muscle relaxant, hypothermic, and sedative properties of ba ...
Lesson 24: Cannabis student notes cannabislessonStudent
... reputable sources will claim that one cannabinoid, 9-THC or delta-9 tetra-hydro-cannabinol is THE psychoactive cannabinoid. Since more than 60 cannabinoids have been identified, and since some are present in Cannabis sativa and not Cannabis indica (and the converse), it is probably too simple to im ...
... reputable sources will claim that one cannabinoid, 9-THC or delta-9 tetra-hydro-cannabinol is THE psychoactive cannabinoid. Since more than 60 cannabinoids have been identified, and since some are present in Cannabis sativa and not Cannabis indica (and the converse), it is probably too simple to im ...
EFFECT OF VALERIAN ROOT EXTRACTS (VALERIANA
... Herbal products have been shown to cause serious interactions when combined with conventional medications. A majority of these interactions are pharmacokinetic in nature and involve alteration in the activity of drug metabolizing enzymes. Valerian is a popular herbal product often used to treat inso ...
... Herbal products have been shown to cause serious interactions when combined with conventional medications. A majority of these interactions are pharmacokinetic in nature and involve alteration in the activity of drug metabolizing enzymes. Valerian is a popular herbal product often used to treat inso ...
Full-Text PDF
... process, and is endued with the ability to produce more than one thousand thrombin molecules [2,4]. Furthermore, currently available FXa inhibitors approved by Food and Drug Administration such as rivaroxaban, apixaban and epibaxaban, have been reported to still demonstrate flaws including bleeding ...
... process, and is endued with the ability to produce more than one thousand thrombin molecules [2,4]. Furthermore, currently available FXa inhibitors approved by Food and Drug Administration such as rivaroxaban, apixaban and epibaxaban, have been reported to still demonstrate flaws including bleeding ...
`Spice` Wars - Cayman Chemical
... led to the development of a cyclohexylphenol (CP) series, including CP 47,497 and CP 55,940, which proved to be 20 to 100 times more potent than THC in certain tests. With the discovery of two receptors for cannabinoids, it was hypothesized that compounds could be produced that selectively activated ...
... led to the development of a cyclohexylphenol (CP) series, including CP 47,497 and CP 55,940, which proved to be 20 to 100 times more potent than THC in certain tests. With the discovery of two receptors for cannabinoids, it was hypothesized that compounds could be produced that selectively activated ...
effects of cytochrome p450 enzyme inhibitors and inducers
... Drugs are used in combination to improve the effectiveness of therapy or to treat coexisting diseases making multiple drug therapy common in current clinical practice (Bucsa et al. 2012). However, some combinations may alter the exposure to drug or drugs with consequential undertreatment causing adv ...
... Drugs are used in combination to improve the effectiveness of therapy or to treat coexisting diseases making multiple drug therapy common in current clinical practice (Bucsa et al. 2012). However, some combinations may alter the exposure to drug or drugs with consequential undertreatment causing adv ...
BAX 855, a PEGylated rFVIII product with prolonged half-life
... to yield a rFVIII conjugate with a low PEGylation degree of about 2 moles PEG per FVIII molecule. This optimised modification degree resulted in an improved PK profile for rFVIII without compromising its specific activity. PEGylation sites were identified by employing various HPLC- and MS-based meth ...
... to yield a rFVIII conjugate with a low PEGylation degree of about 2 moles PEG per FVIII molecule. This optimised modification degree resulted in an improved PK profile for rFVIII without compromising its specific activity. PEGylation sites were identified by employing various HPLC- and MS-based meth ...
Conditioned Stimulus Familiarity Determines Effects of MK
... Richardson, 2007; Hofmann et al., 2006; Kushner et al., 2007; Ressler et al., 2004). Taken together, these findings have been interpreted to mean that NMDA receptors are obligatory for the acquisition and the loss of fear. Recent findings, however, have challenged this view. For example, infusions o ...
... Richardson, 2007; Hofmann et al., 2006; Kushner et al., 2007; Ressler et al., 2004). Taken together, these findings have been interpreted to mean that NMDA receptors are obligatory for the acquisition and the loss of fear. Recent findings, however, have challenged this view. For example, infusions o ...