LONG-TERM USE OF INTRATHECAL DROPERIDOL AS AN EXCELLENT ANTIEMETIC IN NONMALIGNANT
... We find droperidol a rather safe drug at the above doses intrathecally. Droperidol was given a “black box warning” by the Food and Drug Administration in 2001. If it is given as an intravenous bolus, at a dose of 0.1 mg/kg, there is an increased chance of ventricular arrhythmia of Torsades de Pointe ...
... We find droperidol a rather safe drug at the above doses intrathecally. Droperidol was given a “black box warning” by the Food and Drug Administration in 2001. If it is given as an intravenous bolus, at a dose of 0.1 mg/kg, there is an increased chance of ventricular arrhythmia of Torsades de Pointe ...
1 - The University of Liverpool Repository
... Results from a Phase III clinical trial have shown that RTS,S/AS01 is able to prevent many cases, particularly amongst children in high impact areas.3 However, strategies to control the mosquito (including insecticide-treated mosquito nets and indoor residual spraying) are at risk due to increase re ...
... Results from a Phase III clinical trial have shown that RTS,S/AS01 is able to prevent many cases, particularly amongst children in high impact areas.3 However, strategies to control the mosquito (including insecticide-treated mosquito nets and indoor residual spraying) are at risk due to increase re ...
Rational Pharmacology
... plasma histamine concentration was 6 ng/ml. If emergency patients with upper GI bleeding then have a histamine release reaction either due to the endoscopy itself” or to any drugs that may be preoperatively given, their reactions may be more severe than in those patients undergoing elective surgery. ...
... plasma histamine concentration was 6 ng/ml. If emergency patients with upper GI bleeding then have a histamine release reaction either due to the endoscopy itself” or to any drugs that may be preoperatively given, their reactions may be more severe than in those patients undergoing elective surgery. ...
I The 1982 John
... a narcotic antagonist. The award was presented at a session of the American Society for Pharmacology and Experimental Therapeutics held during the annual Federation of American Societies for Experimental Biology (FASEB) meeting in Chicago. As a member of the John Scott Award Advisory Committee, I ha ...
... a narcotic antagonist. The award was presented at a session of the American Society for Pharmacology and Experimental Therapeutics held during the annual Federation of American Societies for Experimental Biology (FASEB) meeting in Chicago. As a member of the John Scott Award Advisory Committee, I ha ...
Innovative Biotechnology Companies and their Academic Origins
... ! Once complete, the enriched pools are subjected to DNA sequencing - Binding is confirmed by resubjecting to target protein - Each peptide is then chemically synthesized for further studies of binding affinity and bioactivity ...
... ! Once complete, the enriched pools are subjected to DNA sequencing - Binding is confirmed by resubjecting to target protein - Each peptide is then chemically synthesized for further studies of binding affinity and bioactivity ...
pharmacological modulation of ureteral peristalsis in a
... Importance of chronically instrumented animal studies versus acute experiments. A considerable number of studies on ureteral physiology that are based on in vitro or acute in vivo experiments have been published.14 –17 The most important criticism of these data is the influence of anesthesia and tra ...
... Importance of chronically instrumented animal studies versus acute experiments. A considerable number of studies on ureteral physiology that are based on in vitro or acute in vivo experiments have been published.14 –17 The most important criticism of these data is the influence of anesthesia and tra ...
Articles Exenatide once weekly plus dapagliflozin once daily versus
... Findings Between Sept 4, 2014, and Oct 15, 2015, we randomly assigned 695 patients to receive exenatide plus dapagliflozin (n=231), exenatide alone (n=231; n=1 untreated), or dapagliflozin alone (n=233). The intention-to-treat population comprised 685 participants (mean HbA1c 9·3% [SD 1·1]; 78 mmol/ ...
... Findings Between Sept 4, 2014, and Oct 15, 2015, we randomly assigned 695 patients to receive exenatide plus dapagliflozin (n=231), exenatide alone (n=231; n=1 untreated), or dapagliflozin alone (n=233). The intention-to-treat population comprised 685 participants (mean HbA1c 9·3% [SD 1·1]; 78 mmol/ ...
... loop. In addition, somatostatin is a dominant paracrine agent within the gastric wall to modulate both the release of gastrin from the antrum and the secretion of HC from the oxyntic mucosa. The release of somatostatin is reciprocally linked to that of gastrin; stimulation of somatostatin release is ...
Anti-emetic activity of four species of Genus Cassia in chicks
... oral copper sulfate induces emesis by peripheral action through excitation of visceral afferent nerve fibers of the GIT[42]. It has also been established that the peripheral 5- HT4 play an important role in copper sulfate induced emesis[43,44]. Although the results are significant and comparable wit ...
... oral copper sulfate induces emesis by peripheral action through excitation of visceral afferent nerve fibers of the GIT[42]. It has also been established that the peripheral 5- HT4 play an important role in copper sulfate induced emesis[43,44]. Although the results are significant and comparable wit ...
patrick_tb_ch10
... 'introducing a nitrogen increases the polarity and water solubility of the analogues, and so increased polarity is good for activity' are highly unlikely since the activity should have been improved for all three analogues IIIV. An aromatic hydrogen is unlikely to have any significant steric effect, ...
... 'introducing a nitrogen increases the polarity and water solubility of the analogues, and so increased polarity is good for activity' are highly unlikely since the activity should have been improved for all three analogues IIIV. An aromatic hydrogen is unlikely to have any significant steric effect, ...
pharmacology_2
... 28.Propranolol produces most of its important effects by antagonizing the beta adrenergic effects of catecholamines released by sympathetic nerve stimulation or from the adrenal medulla. It therefore results in all of the following EXCEPT: A. negative inotropic effect on the heart B. bronchoconstric ...
... 28.Propranolol produces most of its important effects by antagonizing the beta adrenergic effects of catecholamines released by sympathetic nerve stimulation or from the adrenal medulla. It therefore results in all of the following EXCEPT: A. negative inotropic effect on the heart B. bronchoconstric ...
Metabotropic Glutamate Receptors
... one of the most important mechanisms of an organism to adapt appropriately to challenges and threats in the environment. An acute stress response results in immediate behavioral and physiological changes including enhanced attention and arousal, increased energy mobilization and increased cardiovasc ...
... one of the most important mechanisms of an organism to adapt appropriately to challenges and threats in the environment. An acute stress response results in immediate behavioral and physiological changes including enhanced attention and arousal, increased energy mobilization and increased cardiovasc ...
Functional Group Characteristics and Roles
... Second, within any given drug molecule or class of drug molecules, some functional groups will be more important than others. This will vary among drug molecules and drug classes. As an example, consider the presence or absence of a simple methyl group. As shown in Figure 2-1, bethanechol and simvas ...
... Second, within any given drug molecule or class of drug molecules, some functional groups will be more important than others. This will vary among drug molecules and drug classes. As an example, consider the presence or absence of a simple methyl group. As shown in Figure 2-1, bethanechol and simvas ...
Practicalities in the Use of Obesity Pharmacologic Agents
... exercise may be effective in increasing weight loss in the first year of use, but much less so in the second year • Qsymia appears to be more effective than lorcaserin, but ...
... exercise may be effective in increasing weight loss in the first year of use, but much less so in the second year • Qsymia appears to be more effective than lorcaserin, but ...
Document
... metabolism, or when the presence of other drugs limited the metabolism of terfenadine, persistent levels resulted in the observed arrythmias. Therefore, the fexofenadine replaced terfenadine (1997). Ventricular Arrythmias are not good! ...
... metabolism, or when the presence of other drugs limited the metabolism of terfenadine, persistent levels resulted in the observed arrythmias. Therefore, the fexofenadine replaced terfenadine (1997). Ventricular Arrythmias are not good! ...
High-Throughput Screening - Journal of Applied Pharmaceutical
... detection techniques like fluorescence resonance energy transfer (FRET), Homogeneous time resolved fluorescence (HTRF), etc are available, and the screening of more than 100,000 samples per day is possible. With the introduction of robotics, automation and miniaturization techniques, it became feasi ...
... detection techniques like fluorescence resonance energy transfer (FRET), Homogeneous time resolved fluorescence (HTRF), etc are available, and the screening of more than 100,000 samples per day is possible. With the introduction of robotics, automation and miniaturization techniques, it became feasi ...
STUDY OF THE ROLE OF THE BED NUCLEUS OF
... model to provide explanatory power and to assess how various variables influence the development of addiction. Predictive validity refers to the model’s ability to produce valid predictions about the human form of addiction based on results from the animal model (Koob and Le Moal, 2006). Another rea ...
... model to provide explanatory power and to assess how various variables influence the development of addiction. Predictive validity refers to the model’s ability to produce valid predictions about the human form of addiction based on results from the animal model (Koob and Le Moal, 2006). Another rea ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
... Treatment is symptomatic only, not curative Symptomatic treatment does not eliminate ...
... Treatment is symptomatic only, not curative Symptomatic treatment does not eliminate ...
Advances in pharmacotherapy for allergic conjunctivitis
... and Eye Allergy Relief. Although there is a mismatch between the duration of the decongestant and the antihistamine in these formulations, with the former lasting only 1 -- 2 h, and the latter, 3 -- 4 h [19,20], the immediate relief that patients perceive when using these products has added greatly ...
... and Eye Allergy Relief. Although there is a mismatch between the duration of the decongestant and the antihistamine in these formulations, with the former lasting only 1 -- 2 h, and the latter, 3 -- 4 h [19,20], the immediate relief that patients perceive when using these products has added greatly ...
PDF - Santen Inc.
... announced the launch of its fourth product IQUIX® (levofloxacin ophthalmic solution) 1.5%, through an agreement with Vistakon Pharmaceuticals, LLC. The agreement gives Vistakon Pharmaceuticals exclusive U.S. marketing and distribution rights for IQUIX, Santen’s most recent ocular anti-infective medi ...
... announced the launch of its fourth product IQUIX® (levofloxacin ophthalmic solution) 1.5%, through an agreement with Vistakon Pharmaceuticals, LLC. The agreement gives Vistakon Pharmaceuticals exclusive U.S. marketing and distribution rights for IQUIX, Santen’s most recent ocular anti-infective medi ...
Glycoprotein 130 Receptor Signaling Mediates a-Cell
... (7,20), with effects on a-cell glucagon secretion, GLP-1 secretion, and survival (21,22). IL-6 is part of a family of IL-6–type cytokines that all share the same common signal transducer for signaling, the glycoprotein 130 (gp130) (23). In support of a role for IL-6 cytokines in human disease, a rec ...
... (7,20), with effects on a-cell glucagon secretion, GLP-1 secretion, and survival (21,22). IL-6 is part of a family of IL-6–type cytokines that all share the same common signal transducer for signaling, the glycoprotein 130 (gp130) (23). In support of a role for IL-6 cytokines in human disease, a rec ...
Guidelines on evaluation of monoclonal antibodies as similar
... useful for confirming the comparability of higher-order structure. An understanding of the mechanism of action (MoA) and receptor interactions of the mAb is important for considering the strategy for biological activity assessment in both the characterization study and the comparability study. MAbs ...
... useful for confirming the comparability of higher-order structure. An understanding of the mechanism of action (MoA) and receptor interactions of the mAb is important for considering the strategy for biological activity assessment in both the characterization study and the comparability study. MAbs ...